Apabetalone, a Clinical-Stage, Selective BET Inhibitor, Opposes DUX4 Target Gene Expression in Primary Human FSHD Muscle Cells

por Sarsons, Christopher D., Gilham, Dean, Tsujikawa, Laura M., Wasiak, Sylwia, Fu, Li, Rakai, Brooke D., Stotz, Stephanie C., Carestia, Agostina, Sweeney, Michael, Kulikowski, Ewelina
Publicado 2023

APABETALONE (RVX-208) REDUCES ACE2 PROTEIN ABUNDANCE AND PREVENTS SARS-COV-2 SPIKE PROTEIN BINDING TO HUMAN LUNG CELLS, A MOA THAT COULD ATTENUATE VIRAL ENTRY

por Fu, Li, Gilham, Dean, Tsujikawa, Laura, Rakai, Brooke D., Wasiak, Sylwia, Stotz, Stephanie, Sarsons, Christopher D., Sweeney, Michael, Johansson, Jan, Wong, Norman, Kulikowski, Ewelina
Publicado 2021

Surface-grafted polyethylene glycol conformation impacts the transport of PEG-functionalized liposomes through a tumour extracellular matrix model

por Labouta, Hagar I., Gomez-Garcia, M. Juliana, Sarsons, Christopher D., Nguyen, Trinh, Kennard, Jacob, Ngo, Wayne, Terefe, Kaisha, Iragorri, Nicolas, Lai, Patrick, Rinker, Kristina D., Cramb, David T.
Publicado 2018

Apabetalone Downregulates Fibrotic, Inflammatory and Calcific Processes in Renal Mesangial Cells and Patients with Renal Impairment

por Gilham, Dean, Wasiak, Sylwia, Rakai, Brooke D., Fu, Li, Tsujikawa, Laura M., Sarsons, Christopher D., Carestia, Agostina, Lebioda, Kenneth, Johansson, Jan O., Sweeney, Michael, Kalantar-Zadeh, Kamyar, Kulikowski, Ewelina
Publicado 2023

Dual mechanism: Epigenetic inhibitor apabetalone reduces SARS-CoV-2 Delta and Omicron variant spike binding and attenuates SARS-CoV-2 RNA induced inflammation

por Fu, Li, Gilham, Dean, Stotz, Stephanie C., Sarsons, Christopher D., Rakai, Brooke D., Tsujikawa, Laura M., Wasiak, Sylwia, Johansson, Jan O., Sweeney, Michael, Wong, Norman C.W., Kulikowski, Ewelina
Publicado 2023

Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism

por Tsujikawa, Laura M., Fu, Li, Das, Shovon, Halliday, Christopher, Rakai, Brooke D., Stotz, Stephanie C., Sarsons, Christopher D., Gilham, Dean, Daze, Emily, Wasiak, Sylwia, Studer, Deborah, Rinker, Kristina D., Sweeney, Michael, Johansson, Jan O., Wong, Norman C. W., Kulikowski, Ewelina
Publicado 2019