Differential splicing of neuronal genes in a Trem2*R47H mouse model mimics alterations associated with Alzheimer’s disease

por Pandey, Ravi S., Kotredes, Kevin P., Sasner, Michael, Howell, Gareth R., Carter, Gregory W.
Publicado 2023

Aging Related Transcriptomic Changes in the Mouse Models of Alzheimer’s Disease

por Uyar, Asli, Pandey, Ravi, Preuss, Christoph, Kotredes, Kevin, Howell, Gareth, Sasner, Michael, Carter, Gregory
Publicado 2020

Determining the Role of ApoE4 in Age-Related Cerebrovascular Decline

por Foley, Kate, Borchian, Peter, Garceau, Dylan, Kotredes, Kevin, Territo, Paul, Sasner, Michael, Howell, Gareth, Diemler, Cory
Publicado 2020

APOE ε4 and exercise interact in a sex‐specific manner to modulate dementia risk factors

por Foley, Kate E., Diemler, Cory A., Hewes, Amanda A., Garceau, Dylan T., Sasner, Michael, Howell, Gareth R.
Publicado 2022

The APOE(ε3/ε4) Genotype Drives Distinct Gene Signatures in the Cortex of Young Mice

por Foley, Kate E., Hewes, Amanda A., Garceau, Dylan T., Kotredes, Kevin P., Carter, Gregory W., Sasner, Michael, Howell, Gareth R.
Publicado 2022

The GBA1 D409V mutation exacerbates synuclein pathology to differing extents in two alpha-synuclein models

por Polinski, Nicole K., Martinez, Terina N., Ramboz, Sylvie, Sasner, Michael, Herberth, Mark, Switzer, Robert, Ahmad, Syed O., Pelligrino, Lee J., Clark, Sean W., Marcus, Jacob N., Smith, Sean M., Dave, Kuldip D., Frasier, Mark A.
Publicado 2022

PIP2 depletion and altered endocytosis caused by expression of Alzheimer's disease‐protective variant PLCγ2 R522

por Maguire, Emily, Menzies, Georgina E, Phillips, Thomas, Sasner, Michael, Williams, Harriet M, Czubala, Magdalena A, Evans, Neil, Cope, Emma L, Sims, Rebecca, Howell, Gareth R, Lloyd‐Evans, Emyr, Williams, Julie, Allen, Nicholas D, Taylor, Philip R
Publicado 2021

A novel systems biology approach to evaluate mouse models of late-onset Alzheimer’s disease

por Preuss, Christoph, Pandey, Ravi, Piazza, Erin, Fine, Alexander, Uyar, Asli, Perumal, Thanneer, Garceau, Dylan, Kotredes, Kevin P., Williams, Harriet, Mangravite, Lara M., Lamb, Bruce T., Oblak, Adrian L., Howell, Gareth R., Sasner, Michael, Logsdon, Benjamin A., Carter, Gregory W.
Publicado 2020

A Bayesian Framework for Generalized Linear Mixed Modeling Identifies New Candidate Loci for Late-Onset Alzheimer’s Disease

por Wang, Xulong, Philip, Vivek M., Ananda, Guruprasad, White, Charles C., Malhotra, Ankit, Michalski, Paul J., Karuturi, Krishna R. Murthy, Chintalapudi, Sumana R., Acklin, Casey, Sasner, Michael, Bennett, David A., De Jager, Philip L., Howell, Gareth R., Carter, Gregory W.
Publicado 2018

Large-scale discovery of mouse transgenic integration sites reveals frequent structural variation and insertional mutagenesis

por Goodwin, Leslie O., Splinter, Erik, Davis, Tiffany L., Urban, Rachel, He, Hao, Braun, Robert E., Chesler, Elissa J., Kumar, Vivek, van Min, Max, Ndukum, Juliet, Philip, Vivek M., Reinholdt, Laura G., Svenson, Karen, White, Jacqueline K., Sasner, Michael, Lutz, Cathleen, Murray, Stephen A.
Publicado 2019

Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer’s disease

por De Schepper, Sebastiaan, Ge, Judy Z., Crowley, Gerard, Ferreira, Laís S. S., Garceau, Dylan, Toomey, Christina E., Sokolova, Dimitra, Rueda-Carrasco, Javier, Shin, Sun-Hye, Kim, Jung-Seok, Childs, Thomas, Lashley, Tammaryn, Burden, Jemima J., Sasner, Michael, Sala Frigerio, Carlo, Jung, Steffen, Hong, Soyon
Publicado 2023

Model organism development and evaluation for late‐onset Alzheimer's disease: MODEL‐AD

por Oblak, Adrian L., Forner, Stefania, Territo, Paul R., Sasner, Michael, Carter, Gregory W., Howell, Gareth R., Sukoff‐Rizzo, Stacey J., Logsdon, Benjamin A., Mangravite, Lara M., Mortazavi, Ali, Baglietto‐Vargas, David, Green, Kim N., MacGregor, Grant R., Wood, Marcelo A., Tenner, Andrea J., LaFerla, Frank M., Lamb, Bruce T.
Publicado 2020

Decreased glucocerebrosidase activity and substrate accumulation of glycosphingolipids in a novel GBA1 D409V knock-in mouse model

por Polinski, Nicole K., Martinez, Terina N., Gorodinsky, Alexander, Gareus, Ralph, Sasner, Michael, Herberth, Mark, Switzer, Robert, Ahmad, Syed O., Cosden, Mali, Kandebo, Monika, Drolet, Robert E., Buckett, Peter D., Shan, Weisong, Chen, Yi, Pellegrino, Lee J., Ellsworth, Gregory D., Dungan, Leo B., Hirst, Warren D., Clark, Sean W., Dave, Kuldip D.
Publicado 2021

Uncovering Disease Mechanisms in a Novel Mouse Model Expressing Humanized APOEε4 and Trem2*R47H

por Kotredes, Kevin P., Oblak, Adrian, Pandey, Ravi S., Lin, Peter Bor-Chian, Garceau, Dylan, Williams, Harriet, Uyar, Asli, O’Rourke, Rita, O’Rourke, Sarah, Ingraham, Cynthia, Bednarczyk, Daria, Belanger, Melisa, Cope, Zackary, Foley, Kate E., Logsdon, Benjamin A., Mangravite, Lara M., Sukoff Rizzo, Stacey J., Territo, Paul R., Carter, Gregory W., Sasner, Michael, Lamb, Bruce T., Howell, Gareth R.
Publicado 2021

Corrigendum: Uncovering Disease Mechanisms in a Novel Mouse Model Expressing Humanized APOEε4 and Trem2(*)R47H

por Kotredes, Kevin P., Oblak, Adrian, Pandey, Ravi S., Lin, Peter Bor-Chian, Garceau, Dylan, Williams, Harriet, Uyar, Asli, O'Rourke, Rita, O'Rourke, Sarah, Ingraham, Cynthia, Bednarczyk, Daria, Belanger, Melisa, Cope, Zackary, Foley, Kate E., Logsdon, Benjamin A., Mangravite, Lara M., Sukoff Rizzo, Stacey J., Territo, Paul R., Carter, Gregory W., Sasner, Michael, Lamb, Bruce T., Howell, Gareth R.
Publicado 2022

Plcg2(M28L) Interacts With High Fat/High Sugar Diet to Accelerate Alzheimer’s Disease-Relevant Phenotypes in Mice

por Oblak, Adrian L., Kotredes, Kevin P., Pandey, Ravi S., Reagan, Alaina M., Ingraham, Cynthia, Perkins, Bridget, Lloyd, Christopher, Baker, Deborah, Lin, Peter B., Soni, Disha M., Tsai, Andy P., Persohn, Scott A., Bedwell, Amanda A., Eldridge, Kierra, Speedy, Rachael, Meyer, Jill A., Peters, Johnathan S., Figueiredo, Lucas L., Sasner, Michael, Territo, Paul R., Sukoff Rizzo, Stacey J., Carter, Gregory W., Lamb, Bruce T., Howell, Gareth R.
Publicado 2022

Prophylactic evaluation of verubecestat on disease‐ and symptom‐modifying effects in 5XFAD mice

por Oblak, Adrian L., Cope, Zackary A., Quinney, Sara K., Pandey, Ravi S., Biesdorf, Carla, Masters, Andi R., Onos, Kristen D., Haynes, Leslie, Keezer, Kelly J., Meyer, Jill A., Peters, Jonathan S., Persohn, Scott A., Bedwell, Amanda A., Eldridge, Kierra, Speedy, Rachael, Little, Gabriela, Williams, Sean‐Paul, Noarbe, Brenda, Obenaus, Andre, Sasner, Michael, Howell, Gareth R., Carter, Gregory W., Williams, Harriet, Lamb, Bruce T., Territo, Paul R., Sukoff Rizzo, Stacey J.
Publicado 2022

Pharmacokinetic, pharmacodynamic, and transcriptomic analysis of chronic levetiracetam treatment in 5XFAD mice: A MODEL‐AD preclinical testing core study

por Onos, Kristen D., Quinney, Sara K., Jones, David R., Masters, Andrea R., Pandey, Ravi, Keezer, Kelly J., Biesdorf, Carla, Metzger, Ingrid F., Meyers, Jill A., Peters, Johnathon, Persohn, Scott C., McCarthy, Brian P., Bedwell, Amanda A., Figueiredo, Lucas L., Cope, Zackary A., Sasner, Michael, Howell, Gareth R., Williams, Harriet M., Oblak, Adrian L., Lamb, Bruce T., Carter, Gregory W., Rizzo, Stacey J. Sukoff, Territo, Paul R.
Publicado 2022

Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study

por Oblak, Adrian L., Lin, Peter B., Kotredes, Kevin P., Pandey, Ravi S., Garceau, Dylan, Williams, Harriet M., Uyar, Asli, O’Rourke, Rita, O’Rourke, Sarah, Ingraham, Cynthia, Bednarczyk, Daria, Belanger, Melisa, Cope, Zackary A., Little, Gabriela J., Williams, Sean-Paul G., Ash, Carl, Bleckert, Adam, Ragan, Tim, Logsdon, Benjamin A., Mangravite, Lara M., Sukoff Rizzo, Stacey J., Territo, Paul R., Carter, Gregory W., Howell, Gareth R., Sasner, Michael, Lamb, Bruce T.
Publicado 2021

Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia

por Xia, Dan, Lianoglou, Steve, Sandmann, Thomas, Calvert, Meredith, Suh, Jung H., Thomsen, Elliot, Dugas, Jason, Pizzo, Michelle E., DeVos, Sarah L., Earr, Timothy K., Lin, Chia-Ching, Davis, Sonnet, Ha, Connie, Leung, Amy Wing-Sze, Nguyen, Hoang, Chau, Roni, Yulyaningsih, Ernie, Lopez, Isabel, Solanoy, Hilda, Masoud, Shababa T., Liang, Chun-chi, Lin, Karin, Astarita, Giuseppe, Khoury, Nathalie, Zuchero, Joy Yu, Thorne, Robert G., Shen, Kevin, Miller, Stephanie, Palop, Jorge J., Garceau, Dylan, Sasner, Michael, Whitesell, Jennifer D., Harris, Julie A., Hummel, Selina, Gnörich, Johannes, Wind, Karin, Kunze, Lea, Zatcepin, Artem, Brendel, Matthias, Willem, Michael, Haass, Christian, Barnett, Daniel, Zimmer, Till S., Orr, Anna G., Scearce-Levie, Kimberly, Lewcock, Joseph W., Di Paolo, Gilbert, Sanchez, Pascal E.
Publicado 2022