Heme Oxygenase-1 Regulates Dendritic Cell Function through Modulation of p38 MAPK-CREB/ATF1 Signaling

por Al-Huseini, Laith M. A., Aw Yeang, Han Xian, Hamdam, Junnat M., Sethu, Swaminathan, Alhumeed, Naif, Wong, Wai, Sathish, Jean G.
Publicado 2014

A Combined In Vitro/In Silico Approach to Identifying Off-Target Receptor Toxicity

por Leedale, Joseph, Sharkey, Kieran J., Colley, Helen E., Norton, Áine M., Peeney, David, Mason, Chantelle L., Sathish, Jean G., Murdoch, Craig, Sharma, Parveen, Webb, Steven D.
Publicado 2018

Loss of Transcription Factor Nuclear Factor-Erythroid 2 (NF-E2) p45-related Factor-2 (Nrf2) Leads to Dysregulation of Immune Functions, Redox Homeostasis, and Intracellular Signali...

por Yeang, Han Xian Aw, Hamdam, Junnat M., Al-Huseini, Laith M. A., Sethu, Swaminathan, Djouhri, Laiche, Walsh, Joanne, Kitteringham, Neil, Park, B. Kevin, Goldring, Christopher E., Sathish, Jean G.
Publicado 2012

Nuclear Factor-erythroid 2 (NF-E2) p45-related Factor-2 (Nrf2) Modulates Dendritic Cell Immune Function through Regulation of p38 MAPK-cAMP-responsive Element Binding Protein/Activ...

por Al-Huseini, Laith M. A., Aw Yeang, Han Xian, Sethu, Swaminathan, Alhumeed, Naif, Hamdam, Junnat M., Tingle, Yulia, Djouhri, Laiche, Kitteringham, Neil, Park, B. Kevin, Goldring, Christopher E., Sathish, Jean G.
Publicado 2013

Failure to upregulate cell surface PD-1 is associated with dysregulated stimulation of T cells by TGN1412-like CD28 superagonist

por Thaventhiran, Thilipan, Alhumeed, Naif, Yeang, Han XA, Sethu, Swaminathan, Downey, Jocelyn S, Alghanem, Ahmad F, Olayanju, Adedamola, Smith, Emma L, Cross, Michael J, Webb, Steven D, Williams, Dominic P, Bristow, Adrian, Ball, Christina, Stebbings, Richard, Sathish, Jean G
Publicado 2014

CD28 Superagonistic Activation of T Cells Induces a Tumor Cell-Like Metabolic Program

por Thaventhiran, Thilipan, Wong, Wai, Alghanem, Ahmad F., Alhumeed, Naif, Aljasir, Mohammad A., Ramsey, Simeon, Sethu, Swaminathan, Yeang, Han Xian Aw, Chadwick, Amy E., Cross, Michael, Webb, Steven D., Djouhri, Laiche, Ball, Christina, Stebbings, Richard, Sathish, Jean G.
Publicado 2019

Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Intravenous Infusions of PF-07304814 (Lufotrelvir) in Participants Hospitalized With COVID-19

por Robinson, Philip, Toussi, Sima S, Aggarwal, Sudeepta, Bergman, Arthur, Zhu, Tong, Hackman, Frances, Sathish, Jean G, Updyke, Lawrence, Loudon, Peter, Krishna, Ganesh, Clevenbergh, Philippe, Hernandez-Mora, Miguel Gorgolas, Cisneros Herreros, Jose Miguel, Albertson, Timothy E, Dougan, Michael, Thacker, Amber, Baniecki, Mary Lynn, Soares, Holly, Whitlock, Mark, Nucci, Gianluca, Menon, Sandeep, Anderson, Annaliesa S, Binks, Michael
Publicado 2023

Challenges and approaches for the development of safer immunomodulatory biologics

por Sathish, Jean G., Sethu, Swaminathan, Bielsky, Marie-Christine, de Haan, Lolke, French, Neil S., Govindappa, Karthik, Green, James, Griffiths, Christopher E. M., Holgate, Stephen, Jones, David, Kimber, Ian, Moggs, Jonathan, Naisbitt, Dean J., Pirmohamed, Munir, Reichmann, Gabriele, Sims, Jennifer, Subramanyam, Meena, Todd, Marque D., Van Der Laan, Jan Willem, Weaver, Richard J., Park, B. Kevin
Publicado 2013

Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19

por Boras, Britton, Jones, Rhys M., Anson, Brandon J., Arenson, Dan, Aschenbrenner, Lisa, Bakowski, Malina A., Beutler, Nathan, Binder, Joseph, Chen, Emily, Eng, Heather, Hammond, Holly, Hammond, Jennifer, Haupt, Robert E., Hoffman, Robert, Kadar, Eugene P., Kania, Rob, Kimoto, Emi, Kirkpatrick, Melanie G., Lanyon, Lorraine, Lendy, Emma K., Lillis, Jonathan R., Logue, James, Luthra, Suman A., Ma, Chunlong, Mason, Stephen W., McGrath, Marisa E., Noell, Stephen, Obach, R. Scott, O’ Brien, Matthew N., O’Connor, Rebecca, Ogilvie, Kevin, Owen, Dafydd, Pettersson, Martin, Reese, Matthew R., Rogers, Thomas F., Rosales, Romel, Rossulek, Michelle I., Sathish, Jean G., Shirai, Norimitsu, Steppan, Claire, Ticehurst, Martyn, Updyke, Lawrence W., Weston, Stuart, Zhu, Yuao, White, Kris M., García-Sastre, Adolfo, Wang, Jun, Chatterjee, Arnab K., Mesecar, Andrew D., Frieman, Matthew B., Anderson, Annaliesa S., Allerton, Charlotte
Publicado 2021