A Human Challenge Model for Mycobacterium tuberculosis Using Mycobacterium bovis Bacille Calmette-Guérin

por Minassian, Angela M., Satti, Iman, Poulton, Ian D., Meyer, Joel, Hill, Adrian V. S., McShane, Helen
Publicado 2012

Gene Expression and Cytokine Profile Correlate With Mycobacterial Growth in a Human BCG Challenge Model

por Matsumiya, Magali, Satti, Iman, Chomka, Agnieszka, Harris, Stephanie A., Stockdale, Lisa, Meyer, Joel, Fletcher, Helen A., McShane, Helen
Publicado 2015

Assay optimisation and technology transfer for multi-site immuno-monitoring in vaccine trials

por Smith, Steven G., Harris, Stephanie A., Satti, Iman, Bryan, Donna, Walker, K. Barry, Dockrell, Hazel M., McShane, Helen, Ho, Mei Mei
Publicado 2017

Evaluation of a Human BCG Challenge Model to Assess Antimycobacterial Immunity Induced by BCG and a Candidate Tuberculosis Vaccine, MVA85A, Alone and in Combination

por Harris, Stephanie A., Meyer, Joel, Satti, Iman, Marsay, Leanne, Poulton, Ian D., Tanner, Rachel, Minassian, Angela M., Fletcher, Helen A., McShane, Helen
Publicado 2014

Optimization of a Human Bacille Calmette-Guérin Challenge Model: A Tool to Evaluate Antimycobacterial Immunity

por Minhinnick, Alice, Harris, Stephanie, Wilkie, Morven, Peter, Jonathan, Stockdale, Lisa, Manjaly-Thomas, Zita-Rose, Vermaak, Samantha, Satti, Iman, Moss, Paul, McShane, Helen
Publicado 2016

Comparing the safety and immunogenicity of a candidate TB vaccine MVA85A administered by intramuscular and intradermal delivery()

por Meyer, Joel, Harris, Stephanie A., Satti, Iman, Poulton, Ian D., Poyntz, Hazel C., Tanner, Rachel, Rowland, Rosalind, Griffiths, Kristin L., Fletcher, Helen A., McShane, Helen
Publicado 2013

Safety and immunogenicity of a candidate tuberculosis vaccine MVA85A delivered by aerosol in BCG-vaccinated healthy adults: a phase 1, double-blind, randomised controlled trial

por Satti, Iman, Meyer, Joel, Harris, Stephanie A, Thomas, Zita-Rose Manjaly, Griffiths, Kristin, Antrobus, Richard D, Rowland, Rosalind, Ramon, Raquel Lopez, Smith, Mary, Sheehan, Sharon, Bettinson, Henry, McShane, Helen
Publicado 2014

Inflammatory and myeloid-associated gene expression before and one day after infant vaccination with MVA85A correlates with induction of a T cell response

por Matsumiya, Magali, Harris, Stephanie A, Satti, Iman, Stockdale, Lisa, Tanner, Rachel, O’Shea, Matthew K, Tameris, Michelle, Mahomed, Hassan, Hatherill, Mark, Scriba, Thomas J, Hanekom, Willem A, McShane, Helen, Fletcher, Helen A
Publicado 2014

Intracellular Cytokine Staining and Flow Cytometry: Considerations for Application in Clinical Trials of Novel Tuberculosis Vaccines

por Smith, Steven G., Smits, Kaatje, Joosten, Simone A., van Meijgaarden, Krista E., Satti, Iman, Fletcher, Helen A., Caccamo, Nadia, Dieli, Francesco, Mascart, Francoise, McShane, Helen, Dockrell, Hazel M., Ottenhoff, Tom H. M.
Publicado 2015

Tools for Assessing the Protective Efficacy of TB Vaccines in Humans: in vitro Mycobacterial Growth Inhibition Predicts Outcome of in vivo Mycobacterial Infection

por Tanner, Rachel, Satti, Iman, Harris, Stephanie A., O'Shea, Matthew K., Cizmeci, Deniz, O'Connor, Daniel, Chomka, Agnieszka, Matsumiya, Magali, Wittenberg, Rachel, Minassian, Angela M., Meyer, Joel, Fletcher, Helen A., McShane, Helen
Publicado 2020

Inflammation and immune activation are associated with risk of Mycobacterium tuberculosis infection in BCG-vaccinated infants

por Satti, Iman, Wittenberg, Rachel E., Li, Shuailin, Harris, Stephanie A., Tanner, Rachel, Cizmeci, Deniz, Jacobs, Ashley, Williams, Nicola, Mulenga, Humphrey, Fletcher, Helen A., Scriba, Thomas J., Tameris, Michele, Hatherill, Mark, McShane, Helen
Publicado 2022

Immunological correlates of mycobacterial growth inhibition describe a spectrum of tuberculosis infection

por O’Shea, Matthew K., Tanner, Rachel, Müller, Julius, Harris, Stephanie A., Wright, Danny, Stockdale, Lisa, Stylianou, Elena, Satti, Iman, Smith, Steven G., Dunbar, James, Fletcher, Thomas E., Dedicoat, Martin, Cunningham, Adam F., McShane, Helen
Publicado 2018

Alternate aerosol and systemic immunisation with a recombinant viral vector for tuberculosis, MVA85A: A phase I randomised controlled trial

por Manjaly Thomas, Zita-Rose, Satti, Iman, Marshall, Julia L., Harris, Stephanie A., Lopez Ramon, Raquel, Hamidi, Ali, Minhinnick, Alice, Riste, Michael, Stockdale, Lisa, Lawrie, Alison M., Vermaak, Samantha, Wilkie, Morven, Bettinson, Henry, McShane, Helen
Publicado 2019

The effect of current Schistosoma mansoni infection on the immunogenicity of a candidate TB vaccine, MVA85A, in BCG-vaccinated adolescents: An open-label trial

por Wajja, Anne, Kizito, Dennison, Nassanga, Beatrice, Nalwoga, Angela, Kabagenyi, Joyce, Kimuda, Simon, Galiwango, Ronald, Mutonyi, Gertrude, Vermaak, Samantha, Satti, Iman, Verweij, Jaco, Tukahebwa, Edridah, Cose, Stephen, Levin, Jonathan, Kaleebu, Pontiano, Elliott, Alison M., McShane, Helen
Publicado 2017

Process of Assay Selection and Optimization for the Study of Case and Control Samples from a Phase IIb Efficacy Trial of a Candidate Tuberculosis Vaccine, MVA85A

por Harris, Stephanie A., Satti, Iman, Matsumiya, Magali, Stockdale, Lisa, Chomka, Agnieszka, Tanner, Rachel, O'Shea, Matthew K., Manjaly Thomas, Zita-Rose, Tameris, Michele, Mahomed, Hassan, Scriba, Thomas J., Hanekom, Willem A., Fletcher, Helen A., McShane, Helen
Publicado 2014

Development of a non-human primate BCG infection model for the evaluation of candidate tuberculosis vaccines

por Harris, Stephanie A., White, Andrew, Stockdale, Lisa, Tanner, Rachel, Sibley, Laura, Sarfas, Charlotte, Meyer, Joel, Peter, Jonathan, O'Shea, Matthew K., Manjaly Thomas, Zita-Rose, Hamidi, Ali, Satti, Iman, Dennis, Mike J., McShane, Helen, Sharpe, Sally
Publicado 2018

A first-in-human phase 1 trial to evaluate the safety and immunogenicity of the candidate tuberculosis vaccine MVA85A-IMX313, administered to BCG-vaccinated adults

por Minhinnick, Alice, Satti, Iman, Harris, Stephanie, Wilkie, Morven, Sheehan, Sharon, Stockdale, Lisa, Thomas, Zita-Rose Manjaly, Lopez-Ramon, Raquel, Poulton, Ian, Lawrie, Alison, Vermaak, Samantha, Le Vert, Alexandre, Del Campo, Judith, Hill, Fergal, Moss, Paul, McShane, Helen
Publicado 2016

Functional in-vitro evaluation of the non-specific effects of BCG vaccination in a randomised controlled clinical study

por Wilkie, Morven, Tanner, Rachel, Wright, Daniel, Lopez Ramon, Raquel, Beglov, Julia, Riste, Michael, Marshall, Julia L., Harris, Stephanie A., Bettencourt, Paulo J. G., Hamidi, Ali, van Diemen, Pauline M., Moss, Paul, Satti, Iman, Wyllie, David, McShane, Helen
Publicado 2022

Lessons from the first clinical trial of a non-licensed vaccine among Ugandan adolescents: a phase II field trial of the tuberculosis candidate vaccine, MVA85A

por Wajja, Anne, Namutebi, Milly, Apule, Barbara, Oduru, Gloria, Kiwanuka, Samuel, Akello, Mirriam, Nassanga, Beatrice, Kabagenyi, Joyce, Mpiima, Juma, Vermaak, Samantha, Lawrie, Alison, Satti, Iman, Verweij, Jaco, Cose, Stephen, Levin, Jonathan, Kaleebu, Pontiano, Tukahebwa, Edridah, McShane, Helen, Elliott, Alison M.
Publicado 2018

The in vitro direct mycobacterial growth inhibition assay (MGIA) for the early evaluation of TB vaccine candidates and assessment of protective immunity: a protocol for non-human p...

por Tanner, Rachel, Hoogkamer, Emily, Bitencourt, Julia, White, Andrew, Boot, Charelle, Sombroek, Claudia C., Harris, Stephanie A., O'Shea, Matthew K., Wright, Daniel, Wittenberg, Rachel, Sarfas, Charlotte, Satti, Iman, Verreck, Frank A.W., Sharpe, Sally A., Fletcher, Helen A., McShane, Helen
Publicado 2021