Modeling cardiac β-adrenergic signaling with normalized-Hill differential equations: comparison with a biochemical model

por Kraeutler, Matthew J, Soltis, Anthony R, Saucerman, Jeffrey J
Publicado 2010

Graphical Approach to Model Reduction for Nonlinear Biochemical Networks

por Holland, David O., Krainak, Nicholas C., Saucerman, Jeffrey J.
Publicado 2011

Mechanisms of cyclic AMP compartmentation revealed by computational models

por Saucerman, Jeffrey J., Greenwald, Eric C., Polanowska-Grabowska, Renata
Publicado 2014

Logic-based mechanistic machine learning on high-content images reveals how drugs differentially regulate cardiac fibroblasts

por Nelson, Anders R., Christiansen, Steven L., Naegle, Kristen M., Saucerman, Jeffrey J.
Publicado 2023

Context-specific network modeling identifies new crosstalk in β-adrenergic cardiac hypertrophy

por Khalilimeybodi, Ali, Paap, Alexander M., Christiansen, Steven L. M., Saucerman, Jeffrey J.
Publicado 2020

Mechano-chemo signaling interactions modulate matrix production by cardiac fibroblasts

por Rogers, Jesse D., Holmes, Jeffrey W., Saucerman, Jeffrey J., Richardson, William J.
Publicado 2020

Predictive model identifies key network regulators of cardiomyocyte mechano-signaling

por Tan, Philip M., Buchholz, Kyle S., Omens, Jeffrey H., McCulloch, Andrew D., Saucerman, Jeffrey J.
Publicado 2017

Regulation of Nuclear PKA revealed by spatiotemporal manipulation of cAMP

por Sample, Vedangi, DiPilato, Lisa M., Yang, Jason H., Ni, Qiang, Saucerman, Jeffrey J., Zhang, Jin
Publicado 2012

Network model‐based screen for FDA‐approved drugs affecting cardiac fibrosis

por Zeigler, Angela C., Chandrabhatla, Anirudha S., Christiansen, Steven L., Nelson, Anders R., Holmes, Jeffrey W., Saucerman, Jeffrey J.
Publicado 2021

High content analysis identifies unique morphological features of reprogrammed cardiomyocytes

por Sutcliffe, Matthew D., Tan, Philip M., Fernandez-Perez, Antonio, Nam, Young-Jae, Munshi, Nikhil V., Saucerman, Jeffrey J.
Publicado 2018

Mechanistic Systems Modeling to Improve Understanding and Prediction of Cardiotoxicity Caused by Targeted Cancer Therapeutics

por Shim, Jaehee V., Chun, Bryan, van Hasselt, Johan G. C., Birtwistle, Marc R., Saucerman, Jeffrey J., Sobie, Eric A.
Publicado 2017

Redistribution of lamina-associated domains reshapes binding of pioneer factor FOXA2 in development of nonalcoholic fatty liver disease

por Wei, Xiaolong, Murphy, Megan A., Reddy, Nihal A., Hao, Yi, Eggertsen, Taylor G., Saucerman, Jeffrey J., Bochkis, Irina M.
Publicado 2022

Multiscale Coupling of an Agent-Based Model of Tissue Fibrosis and a Logic-Based Model of Intracellular Signaling

por Rikard, S. Michaela, Athey, Thomas L., Nelson, Anders R., Christiansen, Steven L. M., Lee, Jia-Jye, Holmes, Jeffrey W., Peirce, Shayn M., Saucerman, Jeffrey J.
Publicado 2019

A personalized, multiomics approach identifies genes involved in cardiac hypertrophy and heart failure

por Santolini, Marc, Romay, Milagros C., Yukhtman, Clara L., Rau, Christoph D., Ren, Shuxun, Saucerman, Jeffrey J., Wang, Jessica J., Weiss, James N., Wang, Yibin, Lusis, Aldons J., Karma, Alain
Publicado 2018

Mapping macrophage polarization over the myocardial infarction time continuum

por Mouton, Alan J., DeLeon-Pennell, Kristine Y., Rivera Gonzalez, Osvaldo J., Flynn, Elizabeth R., Freeman, Tom C., Saucerman, Jeffrey J., Garrett, Michael R., Ma, Yonggang, Harmancey, Romain, Lindsey, Merry L.
Publicado 2018

Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy

por Laker, Rhianna C., Drake, Joshua C., Wilson, Rebecca J., Lira, Vitor A., Lewellen, Bevan M., Ryall, Karen A., Fisher, Carleigh C., Zhang, Mei, Saucerman, Jeffrey J., Goodyear, Laurie J., Kundu, Mondira, Yan, Zhen
Publicado 2017

The Cell Surface Receptors Ror1/2 Control Cardiac Myofibroblast Differentiation

por Chavkin, Nicholas W., Sano, Soichi, Wang, Ying, Oshima, Kosei, Ogawa, Hayato, Horitani, Keita, Sano, Miho, MacLauchlan, Susan, Nelson, Anders, Setia, Karishma, Vippa, Tanvi, Watanabe, Yosuke, Saucerman, Jeffrey J., Hirschi, Karen K., Gokce, Noyan, Walsh, Kenneth
Publicado 2021

Systems Analysis of Small Signaling Modules Relevant to Eight Human Diseases

por Benedict, Kelly F., Mac Gabhann, Feilim, Amanfu, Robert K., Chavali, Arvind K., Gianchandani, Erwin P., Glaw, Lydia S., Oberhardt, Matthew A., Thorne, Bryan C., Yang, Jason H., Papin, Jason A., Peirce, Shayn M., Saucerman, Jeffrey J., Skalak, Thomas C.
Publicado 2010