Targeting sickle cell disease root-cause pathophysiology with small molecules

por Saunthararajah, Yogen
Publicado 2019

Mysteries of partial dihydroorotate dehydrogenase inhibition and leukemia terminal differentiation

por Saunthararajah, Yogen
Publicado 2020

5-aza-2′,2′-Difluroro Deoxycytidine (NUC013): A Novel Nucleoside DNA Methyl Transferase Inhibitor and Ribonucleotide Reductase Inhibitor for the Treatment of Cancer

por Daifuku, Richard, Hu, Zhenbo, Saunthararajah, Yogen
Publicado 2017

Severe pyoderma gangrenosum caused by myelodysplastic syndrome successfully treated with decitabine administered by a noncytotoxic regimen

por Saleh, Mostafa F. M., Saunthararajah, Yogen
Publicado 2017

Differentiation therapy and the mechanisms that terminate cancer cell proliferation without harming normal cells

por Enane, Francis O., Saunthararajah, Yogen, Korc, Murray
Publicado 2018

High cytidine deaminase expression in the liver provides sanctuary for cancer cells from decitabine treatment effects

por Ebrahem, Quteba, Mahfouz, Reda, Ng, Kwok Peng, Saunthararajah, Yogen
Publicado 2012

DNA Methyltransferase 1 Targeting Using Guadecitabine Inhibits Prostate Cancer Growth by an Apoptosis-Independent Pathway

por Karan, Dev, Singh, Manohar, Dubey, Seema, Van Veldhuizen, Peter J., Saunthararajah, Yogen
Publicado 2023

Decitabine Suspends Human CD34(+) Cell Differentiation and Proliferation during Lentiviral Transduction

por Uchida, Naoya, Hsieh, Matthew M., Platner, Charlotte, Saunthararajah, Yogen, Tisdale, John F.
Publicado 2014

Clinical Trials Assessing Hypomethylating Agents Combined with Other Therapies: Causes for Failure and Potential Solutions

por Zavras, Phaedon D., Shastri, Aditi, Goldfinger, Mendel, Verma, Amit K., Saunthararajah, Yogen
Publicado 2021

A non‐cytotoxic regimen of decitabine to treat refractory T‐cell large granular lymphocytic leukemia

por Zawit, Misam, Gurnari, Carmelo, Pagliuca, Simona, Awada, Hassan, Maciejewski, Jaroslaw P., Saunthararajah, Yogen
Publicado 2021

Tracking Decitabine Incorporation into Malignant Myeloid Cell DNA in vitro and in vivo by LC-MS/MS with Enzymatic Digestion

por Chilakala, Sujatha, Feng, Ye, Li, Lan, Mahfouz, Reda, Quteba, Ebrahem, Saunthararajah, Yogen, Xu, Yan
Publicado 2019

Changing paradigms in oncology: Toward noncytotoxic treatments for advanced gliomas

por von Knebel Doeberitz, Nikolaus, Paech, Daniel, Sturm, Dominik, Pusch, Stefan, Turcan, Sevin, Saunthararajah, Yogen
Publicado 2022

Association of tumor and plasma microRNA expression with tumor monosomy-3 in patients with uveal melanoma

por Triozzi, Pierre L., Achberger, Susan, Aldrich, Wayne, Crabb, John W., Saunthararajah, Yogen, Singh, Arun D.
Publicado 2016

iTRAQ Quantitative Proteomic Comparison of Metastatic and Non-Metastatic Uveal Melanoma Tumors

por Crabb, John W., Hu, Bo, Crabb, John S., Triozzi, Pierre, Saunthararajah, Yogen, Tubbs, Raymond, Singh, Arun D.
Publicado 2015

Combinatorial targeting of epigenome-modifying enzymes with decitabine and RN-1 synergistically increases HbF

por Ibanez, Vinzon, Vaitkus, Kestis, Zhang, Xu, Ramasamy, Jagadeesh, Rivers, Angela E., Saunthararajah, Yogen, Molokie, Robert, Lavelle, Donald
Publicado 2023

dNTP Supply Gene Expression Patterns after P53 Loss

por Radivoyevitch, Tomas, Saunthararajah, Yogen, Pink, John, Ferris, Gina, Lent, Ian, Jackson, Mark, Junk, Damian, Kunos, Charles A.
Publicado 2012

Effect of AGM and Fetal Liver-Derived Stromal Cell Lines on Globin Expression in Adult Baboon (P. anubis) Bone Marrow-Derived Erythroid Progenitors

por Lavelle, Donald, Vaitkus, Kestutis, Ruiz, Maria Armila, Ibanez, Vinzon, Kouznetsova, Tatiana, Saunthararajah, Yogen, Mahmud, Nadim, DeSimone, Joseph
Publicado 2012

Novel pharmacologic approach to enhance the epigenetic and immune priming effect of decitabine in patients with advanced non-small cell lung cancer

por Velcheti, Vamsidhar, Pennell, Nathan A, Rakshit, Sagar, Stevenson, James, Shapiro, Marc, Almeida, Francisco A, Gurajala, Ram, Schalper, Kurt Alex, Saunthararajah, Yogen
Publicado 2015

CpG methylation patterns and decitabine treatment response in acute myeloid leukemia cells and normal hematopoietic precursors

por Negrotto, Soledad, Ng, Kwok Peng, Jankowska, Ania M., Bodo, Juraj, Gopalan, Banu, Guinta, Kathryn, Mulloy, James C., Hsi, Eric, Maciejewski, Jaroslaw, Saunthararajah, Yogen
Publicado 2011

CDC37 as a novel target for the treatment of NPM1-ALK expressing anaplastic large cell lymphomas

por Kuravi, Sudhakiranmayi, Parrott, Elizabeth, Mudduluru, Giridhar, Cheng, Janice, Ganguly, Siddhartha, Saunthararajah, Yogen, Jensen, Roy A., Blagg, Brian S., McGuirk, Joseph P., Balusu, Ramesh
Publicado 2019