Photoredox Ni-catalyzed peptide C(sp(2))–O cross-coupling: from intermolecular reactions to side chain-to-tail macrocyclization

por Lee, Hyelee, Boyer, Nicolas C., Deng, Qiaolin, Kim, Hai-Young, Sawyer, Tomi K., Sciammetta, Nunzio
Publicado 2019

Accelerated Identification of Cell Active KRAS Inhibitory Macrocyclic Peptides using Mixture Libraries and Automated Ligand Identification System (ALIS) Technology

por Garrigou, Michael, Sauvagnat, Bérengère, Duggal, Ruchia, Boo, Nicole, Gopal, Pooja, Johnston, Jennifer M., Partridge, Anthony, Sawyer, Tomi, Biswas, Kaustav, Boyer, Nicolas
Publicado 2022

Rigorous Computational and Experimental Investigations on MDM2/MDMX-Targeted Linear and Macrocyclic Peptides

por Diller, David J., Swanson, Jon, Bayden, Alexander S., Brown, Chris J., Thean, Dawn, Lane, David P., Partridge, Anthony W., Sawyer, Tomi K., Audie, Joseph
Publicado 2019

Demonstration of a Common DPhe(7) to DNal(2′)(7) Peptide Ligand Antagonist Switch for Melanocortin-3 and Melanocortin-4 Receptors Identifies the Systematic Mischaracterization of t...

por Gimenez, Luis E., Noblin, Terry A., Williams, Savannah Y., Mullick Bagchi, Satarupa, Ji, Ren-Lei, Tao, Ya-Xiong, Jeppesen, Claus B., Conde-Frieboes, Kilian W., Sawyer, Tomi K., Grieco, Paolo, Cone, Roger D.
Publicado 2022

Incorporation of Putative Helix-Breaking Amino Acids in the Design of Novel Stapled Peptides: Exploring Biophysical and Cellular Permeability Properties

por Partridge, Anthony W., Kaan, Hung Yi Kristal, Juang, Yu-Chi, Sadruddin, Ahmad, Lim, Shuhui, Brown, Christopher J., Ng, Simon, Thean, Dawn, Ferrer, Fernando, Johannes, Charles, Yuen, Tsz Ying, Kannan, Srinivasaraghavan, Aronica, Pietro, Tan, Yaw Sing, Pradhan, Mohan R., Verma, Chandra S., Hochman, Jerome, Chen, Shiying, Wan, Hui, Ha, Sookhee, Sherborne, Brad, Lane, David P., Sawyer, Tomi K.
Publicado 2019

Macrocyclization of an all-d linear α-helical peptide imparts cellular permeability

por Kannan, Srinivasaraghavan, Aronica, Pietro G. A., Ng, Simon, Gek Lian, Dawn Thean, Frosi, Yuri, Chee, Sharon, Shimin, Jiang, Yuen, Tsz Ying, Sadruddin, Ahmad, Kaan, Hung Yi Kristal, Chandramohan, Arun, Wong, Jin Huei, Tan, Yaw Sing, Chang, Zi Wei, Ferrer-Gago, Fernando J., Arumugam, Prakash, Han, Yi, Chen, Shiying, Rénia, Laurent, Brown, Christopher J., Johannes, Charles W., Henry, Brian, Lane, David P., Sawyer, Tomi K., Verma, Chandra S., Partridge, Anthony W.
Publicado 2020

Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling

por Lim, Shuhui, Boyer, Nicolas, Boo, Nicole, Huang, Chunhui, Venkatachalam, Gireedhar, Angela Juang, Yu-Chi, Garrigou, Michael, Kaan, Hung Yi Kristal, Duggal, Ruchia, Peh, Khong Ming, Sadruddin, Ahmad, Gopal, Pooja, Yuen, Tsz Ying, Ng, Simon, Kannan, Srinivasaraghavan, Brown, Christopher J., Verma, Chandra S., Orth, Peter, Peier, Andrea, Ge, Lan, Yu, Xiang, Bhatt, Bhavana, Chen, Feifei, Wang, Erjia, Li, Nianyu Jason, Gonzales, Raymond J., Stoeck, Alexander, Henry, Brian, Sawyer, Tomi K., Lane, David P., Johannes, Charles W., Biswas, Kaustav, Partridge, Anthony W.
Publicado 2021