Treating Imatinib-Resistant Leukemia: The Next Generation Targeted Therapies

por Burgess, Michael R., Sawyers, Charles L.
Publicado 2006

Challenges in validating candidate therapeutic targets in cancer

por Settleman, Jeffrey, Sawyers, Charles L, Hunter, Tony
Publicado 2018

Visualization of the Interstitial Cells of Cajal (ICC) Network in Mice

por Chen, Yu, Shamu, Tambudzai, Chen, Hui, Besmer, Peter, Sawyers, Charles L., Chi, Ping
Publicado 2011

Fitness Conferred by BCR-ABL Kinase Domain Mutations Determines the Risk of Pre-Existing Resistance in Chronic Myeloid Leukemia

por Leder, Kevin, Foo, Jasmine, Skaggs, Brian, Gorre, Mercedes, Sawyers, Charles L., Michor, Franziska
Publicado 2011

Modulation of androgen receptor DNA binding activity through direct interaction with the ETS transcription factor ERG

por Wasmuth, Elizabeth V., Hoover, Elizabeth A., Antar, Albert, Klinge, Sebastian, Chen, Yu, Sawyers, Charles L.
Publicado 2020

Annotating MYC oncogene status with (89)Zr-transferrin imaging

por Holland, Jason P., Evans, Michael J., Rice, Samuel L., Wongvipat, John, Sawyers, Charles L., Lewis, Jason S.
Publicado 2012

Organoid culture systems for prostate epithelial tissue and prostate cancer tissue

por Drost, Jarno, Karthaus, Wouter R., Gao, Dong, Driehuis, Else, Sawyers, Charles L., Chen, Yu, Clevers, Hans
Publicado 2016

Deletion of 3p13-14 locus spanning FOXP1 to SHQ1 cooperates with PTEN loss in prostate oncogenesis

por Hieronymus, Haley, Iaquinta, Phillip J., Wongvipat, John, Gopalan, Anuradha, Murali, Rajmohan, Mao, Ninghui, Carver, Brett S., Sawyers, Charles L.
Publicado 2017

Modulators of Prostate Cancer Cell Proliferation and Viability Identified by Short-Hairpin RNA Library Screening

por Dahlman, Kimberly Brown, Parker, Joel S., Shamu, Tambudzai, Hieronymus, Haley, Chapinski, Caren, Carver, Brett, Chang, Kenneth, Hannon, Gregory J., Sawyers, Charles L.
Publicado 2012

GREB1 amplifies androgen receptor output in human prostate cancer and contributes to antiandrogen resistance

por Lee, Eugine, Wongvipat, John, Choi, Danielle, Wang, Ping, Lee, Young Sun, Zheng, Deyou, Watson, Philip A, Gopalan, Anuradha, Sawyers, Charles L
Publicado 2019

Addressing racial and ethnic disparities in AACR project GENIE

por Sweeney, Shawn M., Lavery, Jessica A., Fuchs, Hannah E., Lee, Jocelyn A., Brown, Samantha, Panageas, Katherine S., Sawyers, Charles L., Bedard, Philippe L.
Publicado 2023

MYC Cooperates with AKT in Prostate Tumorigenesis and Alters Sensitivity to mTOR Inhibitors

por Clegg, Nicola J., Couto, Suzana S., Wongvipat, John, Hieronymus, Haley, Carver, Brett S., Taylor, Barry S., Ellwood-Yen, Katharine, Gerald, William L., Sander, Chris, Sawyers, Charles L.
Publicado 2011

Applying (89)Zr-Transferrin To Study the Pharmacology of Inhibitors to BET Bromodomain Containing Proteins

por Doran, Michael G., Carnazza, Kathryn E., Steckler, Jeffrey M., Spratt, Daniel E., Truillet, Charles, Wongvipat, John, Sawyers, Charles L., Lewis, Jason S., Evans, Michael J.
Publicado 2016

Overcoming mutation-based resistance to antiandrogens with rational drug design

por Balbas, Minna D, Evans, Michael J, Hosfield, David J, Wongvipat, John, Arora, Vivek K, Watson, Philip A, Chen, Yu, Greene, Geoffrey L, Shen, Yang, Sawyers, Charles L
Publicado 2013

A Tmprss2-CreER(T2) Knock-In Mouse Model for Cancer Genetic Studies on Prostate and Colon

por Gao, Dong, Zhan, Yu, Di, Wei, Moore, Amanda R., Sher, Jessica J., Guan, Youxin, Wang, Shangqian, Zhang, Zeda, Murphy, Devan A., Sawyers, Charles L., Chi, Ping, Chen, Yu
Publicado 2016

ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss

por Chen, Yu, Chi, Ping, Rockowitz, Shira, Iaquinta, Phillip J., Shamu, Tambudzai, Shukla, Shipra, Gao, Dong, Sirota, Inna, Carver, Brett S., Wongvipat, John, Scher, Howard I., Zheng, Deyou, Sawyers, Charles L.
Publicado 2013

ETV1 is a lineage-specific survival factor in GIST and cooperates with KIT in oncogenesis

por Chi, Ping, Chen, Yu, Zhang, Lei, Guo, Xingyi, Wongvipat, John, Shamu, Tambudzai, Fletcher, Jonathan A., Dewell, Scott, Maki, Robert G., Zheng, Deyou, Antonescu, Cristina R., Allis, C. David, Sawyers, Charles L.
Publicado 2010

Tumor copy number alteration burden is a pan-cancer prognostic factor associated with recurrence and death

por Hieronymus, Haley, Murali, Rajmohan, Tin, Amy, Yadav, Kamlesh, Abida, Wassim, Moller, Henrik, Berney, Daniel, Scher, Howard, Carver, Brett, Scardino, Peter, Schultz, Nikolaus, Taylor, Barry, Vickers, Andrew, Cuzick, Jack, Sawyers, Charles L
Publicado 2018

Regulation of the glucocorticoid receptor via a BET-dependent enhancer drives antiandrogen resistance in prostate cancer

por Shah, Neel, Wang, Ping, Wongvipat, John, Karthaus, Wouter R, Abida, Wassim, Armenia, Joshua, Rockowitz, Shira, Drier, Yotam, Bernstein, Bradley E, Long, Henry W, Freedman, Matthew L, Arora, Vivek K, Zheng, Deyou, Sawyers, Charles L
Publicado 2017

CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma

por Huang, Chun-Hao, Lujambio, Amaia, Zuber, Johannes, Tschaharganeh, Darjus F., Doran, Michael G., Evans, Michael J., Kitzing, Thomas, Zhu, Nan, de Stanchina, Elisa, Sawyers, Charles L., Armstrong, Scott A., Lewis, Jason S., Sherr, Charles J., Lowe, Scott W.
Publicado 2014