Synergy between trastuzumab and pertuzumab for human epidermal growth factor 2 (Her2) from colocalization: an in silico based mechanism

por Fuentes, Gloria, Scaltriti, Maurizio, Baselga, José, Verma, Chandra S
Publicado 2011

A network modeling approach to elucidate drug resistance mechanisms and predict combinatorial drug treatments in breast cancer

por Gómez Tejeda Zañudo, Jorge, Scaltriti, Maurizio, Albert, Réka
Publicado 2017

Quantification of HER family receptors in breast cancer

por Nuciforo, Paolo, Radosevic-Robin, Nina, Ng, Tony, Scaltriti, Maurizio
Publicado 2015

The present and future of PI3K inhibitors for cancer therapy

por Castel, Pau, Toska, Eneda, Engelman, Jeffrey A., Scaltriti, Maurizio
Publicado 2021

Molecular mechanisms of assembly and TRIP13-mediated remodeling of the human Shieldin complex

por Xie, Wei, Wang, Shengliu, Wang, Juncheng, de la Cruz, M. Jason, Xu, Guotai, Scaltriti, Maurizio, Patel, Dinshaw J.
Publicado 2021

ER+ Breast Cancer Strongly Depends on MCL-1 and BCL-xL Anti-Apoptotic Proteins

por Alcon, Clara, Zañudo, Jorge Gómez Tejeda, Albert, Reka, Wagle, Nikhil, Scaltriti, Maurizio, Letai, Anthony, Samitier, Josep, Montero, Joan
Publicado 2021

TARGETING THE MUC1-C ONCOPROTEIN DOWNREGULATES HER2 ACTIVATION AND ABROGATES TRASTUZUMAB RESISTANCE IN BREAST CANCER CELLS

por Raina, Deepak, Uchida, Yasumitsu, Kharbanda, Akriti, Rajabi, Hasan, Panchamoorthy, Govind, Jin, Caining, Kharbanda, Surender, Scaltriti, Maurizio, Baselga, Jose, Kufe, Donald
Publicado 2013

Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target

por Cook, Peter J., Thomas, Rozario, Kannan, Ram, de Leon, Esther Sanchez, Drilon, Alexander, Rosenblum, Marc K., Scaltriti, Maurizio, Benezra, Robert, Ventura, Andrea
Publicado 2017

Author Correction: Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target

por Cook, Peter J., Thomas, Rozario, Kannan, Ram, de Leon, Esther Sanchez, Drilon, Alexander, Rosenblum, Marc K., Scaltriti, Maurizio, Benezra, Robert, Ventura, Andrea
Publicado 2018

Inhibitors of HSP90 block p95-HER2 signaling in Trastuzumab-resistant tumors and suppress their growth

por Chandarlapaty, Sarat, Scaltriti, Maurizio, Angelini, Pierdavide, Ye, Qing, Guzman, Marta, Hudis, Clifford A., Norton, Larry, Solit, David B., Arribas, Joaquin, Baselga, Jose, Rosen, Neal
Publicado 2009

Genotyping tumour DNA in cerebrospinal fluid and plasma of a HER2-positive breast cancer patient with brain metastases

por Siravegna, Giulia, Geuna, Elena, Mussolin, Benedetta, Crisafulli, Giovanni, Bartolini, Alice, Galizia, Danilo, Casorzo, Laura, Sarotto, Ivana, Scaltriti, Maurizio, Sapino, Anna, Bardelli, Alberto, Montemurro, Filippo
Publicado 2017

Personalized cancer therapy prioritization based on driver alteration co-occurrence patterns

por Mateo, Lidia, Duran-Frigola, Miquel, Gris-Oliver, Albert, Palafox, Marta, Scaltriti, Maurizio, Razavi, Pedram, Chandarlapaty, Sarat, Arribas, Joaquin, Bellet, Meritxell, Serra, Violeta, Aloy, Patrick
Publicado 2020

Overcoming resistance to HER2-targeted therapy with a novel HER2/CD3 bispecific antibody

por Lopez-Albaitero, Andres, Xu, Hong, Guo, Hongfen, Wang, Linlin, Wu, Zhihao, Tran, Hoa, Chandarlapaty, Sarat, Scaltriti, Maurizio, Janjigian, Yelena, de Stanchina, Elisa, Cheung, Nai-Kong V.
Publicado 2017

Genetic Heterogeneity and Tissue-specific Patterns of Tumors with Multiple PIK3CA Mutations

por Sivakumar, Smruthy, Jin, Dexter X., Rathod, Ruchita, Ross, Jeffrey, Cantley, Lewis C., Scaltriti, Maurizio, Chen, Jessica W., Hutchinson, Katherine E., Wilson, Timothy R., Sokol, Ethan S., Vasan, Neil
Publicado 2023

CDK 4/6 Inhibition Overcomes Acquired and Inherent Resistance to PI3Kα Inhibition in Pre-Clinical Models of Head and Neck Squamous Cell Carcinoma

por Remer, Eric, Badarni, Mai, Hikri, Elad, Dayan, Avraham, Levi, Lirit, Popovtzer, Aron, Iraqi, Muhammed, Porgador, Angel, Joshua, Ben-Zion, Bachar, Gideon, Elkabets, Moshe, Scaltriti, Maurizio, Mizrachi, Aviram
Publicado 2020

Targeting transcription of MCL-1 sensitizes HER2-amplified breast cancers to HER2 inhibitors

por Floros, Konstantinos V., Jacob, Sheeba, Kurupi, Richard, Fairchild, Carter K., Hu, Bin, Puchalapalli, Madhavi, E. Koblinski, Jennifer, Dozmorov, Mikhail G., Boikos, Sosipatros A., Scaltriti, Maurizio, Faber, Anthony C.
Publicado 2021

UDP-glucose pyrophosphorylase 2, a regulator of glycogen synthesis and glycosylation, is critical for pancreatic cancer growth

por Wolfe, Andrew L., Zhou, Qingwen, Toska, Eneda, Galeas, Jacqueline, Ku, Angel A., Koche, Richard P., Bandyopadhyay, Sourav, Scaltriti, Maurizio, Lebrilla, Carlito B., McCormick, Frank, Kim, Sung Eun
Publicado 2021

Solid pseudopapillary neoplasms of the pancreas are dependent on the Wnt pathway

por Selenica, Pier, Raj, Nitya, Kumar, Rahul, Brown, David N., Arqués, Oriol, Reidy, Diane, Klimstra, David, Snuderl, Matija, Serrano, Jonathan, Palmer, Héctor G., Weigelt, Britta, Reis‐Filho, Jorge S., Scaltriti, Maurizio
Publicado 2019

PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition

por Castel, Pau, Ellis, Haley, Bago, Ruzica, Toska, Eneda, Razavi, Pedram, Carmona, F. Javier, Kannan, Srinivasaraghavan, Verma, Chandra S., Dickler, Maura, Chandarlapaty, Sarat, Brogi, Edi, Alessi, Dario R., Baselga, José, Scaltriti, Maurizio
Publicado 2016

Tumour-specific PI3K inhibition via nanoparticle-targeted delivery in head and neck squamous cell carcinoma

por Mizrachi, Aviram, Shamay, Yosi, Shah, Janki, Brook, Samuel, Soong, Joanne, Rajasekhar, Vinagolu K., Humm, John L., Healey, John H., Powell, Simon N., Baselga, José, Heller, Daniel A., Haimovitz-Friedman, Adriana, Scaltriti, Maurizio
Publicado 2017