Driving antimalarial design through understanding of target mechanism

por Calic, Petar P. S., Mansouri, Mahta, Scammells, Peter J., McGowan, Sheena
Publicado 2020

Enantioenriched Positive Allosteric Modulators Display Distinct Pharmacology at the Dopamine D(1) Receptor

por Fyfe, Tim J., Scammells, Peter J., Lane, J. Robert, Capuano, Ben
Publicado 2021

An Allosteric Modulator of the Adenosine A(1) Receptor Improves Cardiac Function Following Ischaemia in Murine Isolated Hearts

por Butcher, Anna, Scammells, Peter J., White, Paul J., Devine, Shane M., Rose’Meyer, Roselyn B.
Publicado 2013

Probe dependence of allosteric enhancers on the binding affinity of adenosine A(1)‐receptor agonists at rat and human A(1)‐receptors measured using NanoBRET

por Cooper, Samantha L., Soave, Mark, Jörg, Manuela, Scammells, Peter J., Woolard, Jeanette, Hill, Stephen J.
Publicado 2019

Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum Aminopeptidases, M1, M17 and M18

por Paiardini, Alessandro, Bamert, Rebecca S., Kannan-Sivaraman, Komagal, Drinkwater, Nyssa, Mistry, Shailesh N., Scammells, Peter J., McGowan, Sheena
Publicado 2015

The effect of two selective A(1)‐receptor agonists and the bitopic ligand VCP746 on heart rate and regional vascular conductance in conscious rats

por Cooper, Samantha L., March, Julie, Sabbatini, Andrea R., Hill, Stephen J., Jörg, Manuela, Scammells, Peter J., Woolard, Jeanette
Publicado 2020

Ionic Liquid Forms of the Antimalarial Lumefantrine in Combination with LFCS Type IIIB Lipid-Based Formulations Preferentially Increase Lipid Solubility, In Vitro Solubilization Be...

por Tay, Erin, Nguyen, Tri-Hung, Ford, Leigh, Williams, Hywel D., Benameur, Hassan, Scammells, Peter J., Porter, Christopher J. H.
Publicado 2019

API ionic liquids: probing the effect of counterion structure on physical form and lipid solubility

por Ford, Leigh, Tay, Erin, Nguyen, Tri-Hung, Williams, Hywel D., Benameur, Hassan, Scammells, Peter J., Porter, Christopher J. H.
Publicado 2020

Probing the binding site of novel selective positive allosteric modulators at the M(1) muscarinic acetylcholine receptor

por Khajehali, Elham, Valant, Celine, Jörg, Manuela, Tobin, Andrew B., Conn, P. Jeffrey, Lindsley, Craig W., Sexton, Patrick M., Scammells, Peter J., Christopoulos, Arthur
Publicado 2018

Biocompatible Cationic Lipoamino Acids as Counterions for Oral Administration of API-Ionic Liquids

por Lai, Anthony, Leong, Nathania, Zheng, Dan, Ford, Leigh, Nguyen, Tri-Hung, Williams, Hywel D., Benameur, Hassan, Scammells, Peter J., Porter, Christopher J. H.
Publicado 2022

Design, Synthesis, and Biological Evaluation of Tetra-Substituted Thiophenes as Inhibitors of p38α MAPK

por Vinh, Natalie B, Devine, Shane M, Munoz, Lenka, Ryan, Renae M, Wang, Bing H, Krum, Henry, Chalmers, David K, Simpson, Jamie S, Scammells, Peter J
Publicado 2015

A new mechanism of allostery in a G protein-coupled receptor dimer

por Lane, J. Robert, Donthamsetti, Prashant, Shonberg, Jeremy, Draper-Joyce, Christopher J., Dentry, Samuel, Michino, Mayako, Shi, Lei, López, Laura, Scammells, Peter J., Capuano, Ben, Sexton, Patrick M., Javitch, Jonathan A., Christopoulos, Arthur
Publicado 2014

The role of kinetic context in apparent biased agonism at GPCRs

por Klein Herenbrink, Carmen, Sykes, David A., Donthamsetti, Prashant, Canals, Meritxell, Coudrat, Thomas, Shonberg, Jeremy, Scammells, Peter J., Capuano, Ben, Sexton, Patrick M., Charlton, Steven J., Javitch, Jonathan A., Christopoulos, Arthur, Lane, J. Robert
Publicado 2016

Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs

por Hollingsworth, Scott A., Kelly, Brendan, Valant, Celine, Michaelis, Jordan Arthur, Mastromihalis, Olivia, Thompson, Geoff, Venkatakrishnan, A. J., Hertig, Samuel, Scammells, Peter J., Sexton, Patrick M., Felder, Christian C., Christopoulos, Arthur, Dror, Ron O.
Publicado 2019

The action of a negative allosteric modulator at the dopamine D(2) receptor is dependent upon sodium ions

por Draper-Joyce, Christopher J., Verma, Ravi Kumar, Michino, Mayako, Shonberg, Jeremy, Kopinathan, Anitha, Klein Herenbrink, Carmen, Scammells, Peter J., Capuano, Ben, Abramyan, Ara M., Thal, David M., Javitch, Jonathan A., Christopoulos, Arthur, Shi, Lei, Lane, J. Robert
Publicado 2018

Genetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway

por Edgar, Rebecca CS, Siddiqui, Ghizal, Hjerrild, Katheryn, Malcolm, Tess R, Vinh, Natalie B, Webb, Chaille T, Holmes, Clare, MacRaild, Christopher A, Chernih, Hope C, Suen, Willy W, Counihan, Natalie A, Creek, Darren J, Scammells, Peter J, McGowan, Sheena, de Koning-Ward, Tania F
Publicado 2022