Pharmacoperone rescue of vasopressin 2 receptor mutants reveals unexpected constitutive activity and coupling bias

por Janovick, Jo Ann, Spicer, Timothy P., Bannister, Thomas D., Scampavia, Louis, Conn, P. Michael
Publicado 2017

Identification of Compounds That Promote Readthrough of Premature Termination Codons in the CFTR

por Smith, Emery, Dukovski, Danijela, Shumate, Justin, Scampavia, Louis, Miller, John P., Spicer, Timothy P.
Publicado 2020

Rescue of mutant gonadotropin-releasing hormone receptor function independent of cognate receptor activity

por Smith, Emery, Janovick, Jo Ann, Bannister, Thomas D., Shumate, Justin, Ganapathy, Vadivel, Scampavia, Louis, Spicer, Timothy P.
Publicado 2020

Identification of novel modulators of a schistosome transient receptor potential channel targeted by praziquantel

por Chulkov, Evgeny G., Smith, Emery, Rohr, Claudia M., Yahya, Nawal A., Park, Sang-Kyu, Scampavia, Louis, Spicer, Timothy P., Marchant, Jonathan S.
Publicado 2021

Elemene sensitizes pancreatic cancer cells to bortezomib by enhancing proteasome inhibition via molecular patch mechanism

por Hou, Shurong, Li, Zhenzhen, Chen, Xiaoling, Wang, Wenxin, Duan, Ting, Scampavia, Louis, Yuan, Yaxia, Spicer, Timothy P., Chen, Xiabin, Xie, Tian
Publicado 2023

Discovery and Optimization of Selective Inhibitors of Meprin α (Part I)

por Hou, Shurong, Diez, Juan, Wang, Chao, Becker-Pauly, Christoph, Fields, Gregg B., Bannister, Thomas, Spicer, Timothy P., Scampavia, Louis D., Minond, Dmitriy
Publicado 2021

Advanced Development of Primary Pancreatic Organoid Tumor Models for High-Throughput Phenotypic Drug Screening

por Hou, Shurong, Tiriac, Hervé, Sridharan, Banu Priya, Scampavia, Louis, Madoux, Franck, Seldin, Jan, Souza, Glauco R., Watson, Donald, Tuveson, David, Spicer, Timothy P.
Publicado 2018

Discovery and Optimization of Selective Inhibitors of Meprin α (Part II)

por Wang, Chao, Diez, Juan, Park, Hajeung, Becker-Pauly, Christoph, Fields, Gregg B., Spicer, Timothy P., Scampavia, Louis D., Minond, Dmitriy, Bannister, Thomas D.
Publicado 2021

A Novel 3-dimensional High Throughput Screening Approach Identifies Inducers of a Mutant KRAS Selective Lethal Phenotype

por Kota, Smitha, Hou, Shurong, Guerrant, William, Madoux, Franck, Troutman, Scott, Fernandez-Vega, Virneliz, Alekseeva, Nina, Madala, Neeharika, Scampavia, Louis, Kissil, Joseph, Spicer, Timothy P.
Publicado 2018

A Simple Procedure for Creating Scalable Phenotypic Screening Assays in Human Neurons

por Sridharan, BanuPriya, Hubbs, Christopher, Llamosas, Nerea, Kilinc, Murat, Singhera, Fakhar U., Willems, Erik, Piper, David R., Scampavia, Louis, Rumbaugh, Gavin, Spicer, Timothy P.
Publicado 2019

Target-based discovery of a broad spectrum flukicide

por Sprague, Daniel J., Park, Sang-Kyu, Gramberg, Svenja, Bauer, Lisa, Rohr, Claudia M., Chulkov, Evgeny G., Smith, Emery, Scampavia, Louis, Spicer, Timothy P., Haeberlein, Simone, Marchant, Jonathan S.
Publicado 2023

Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate

por Madoux, Franck, Dreymuller, Daniela, Pettiloud, Jean-Phillipe, Santos, Radleigh, Becker-Pauly, Christoph, Ludwig, Andreas, Fields, Gregg B., Bannister, Thomas, Spicer, Timothy P., Cudic, Mare, Scampavia, Louis D., Minond, Dmitriy
Publicado 2016

A new vulnerability to BET inhibition due to enhanced autophagy in BRCA2 deficient pancreatic cancer

por Lee, EunJung, Archasappawat, Suyakarn, Ji, Keely, Pena, Jocelyn, Fernandez-Vega, Virneliz, Gangaraju, Ritika, Beesabathuni, Nitin Sai, Kim, Martin Jean, Tian, Qi, Shah, Priya S., Scampavia, Louis, Spicer, Timothy P., Hwang, Chang-Il
Publicado 2023

Identification of Small Molecules that Disrupt Signaling between ABL and Its Positive Regulator RIN1

por Ting, Pamela Y., Damoiseaux, Robert, Titz, Björn, Bradley, Kenneth A., Graeber, Thomas G., Fernández-Vega, Virneliz, Bannister, Thomas D., Chase, Peter, Nair, Reji, Scampavia, Louis, Hodder, Peter, Spicer, Timothy P., Colicelli, John
Publicado 2015

High throughput screening for drugs that inhibit 3C-like protease in SARS-CoV-2

por Smith, Emery, Davis-Gardner, Meredith E., Garcia-Ordonez, Ruben D., Nguyen, Tu-Trinh, Hull, Mitchell, Chen, Emily, Yu, Xuerong, Bannister, Thomas D., Baillargeon, Pierre, Scampavia, Louis, Griffin, Patrick, Farzan, Michael, Spicer, Timothy P.
Publicado 2023

Pharmacologic IRE1/XBP1s Activation Confers Targeted ER Proteostasis Reprogramming

por Grandjean, Julia M.D., Madhavan, Aparajita, Cech, Lauren, Seguinot, Bryan O., Paxman, Ryan J., Smith, Emery, Scampavia, Louis, Powers, Evan T., Cooley, Christina B., Plate, Lars, Spicer, Timothy P., Kelly, Jeffery W., Wiseman, R. Luke
Publicado 2020

In Vitro and In Vivo Drug-Response Profiling Using Patient-Derived High-Grade Glioma

por Rajan, Robin G., Fernandez-Vega, Virneliz, Sperry, Jantzen, Nakashima, Jonathan, Do, Long H., Andrews, Warren, Boca, Simina, Islam, Rezwanul, Chowdhary, Sajeel A., Seldin, Jan, Souza, Glauco R., Scampavia, Louis, Hanafy, Khalid A., Vrionis, Frank D., Spicer, Timothy P.
Publicado 2023

Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment

por Wang, Leiming, Cheng, Chiang-Min, Qin, Jun, Xu, Mafei, Kao, Chung-Yang, Shi, Jingjing, You, Erli, Gong, Wanchun, Rosa, Laura Pedro, Chase, Peter, Scampavia, Louis, Madoux, Franck, Spicer, Timothy, Hodder, Peter, Xu, H. Eric, Tsai, Sophia Y., Tsai, Ming-Jer
Publicado 2020

An unbiased high‐throughput drug screen reveals a potential therapeutic vulnerability in the most lethal molecular subtype of pancreatic cancer

por Pan, Chun‐Hao, Otsuka, Yuka, Sridharan, BanuPriya, Woo, Melissa, Leiton, Cindy V., Babu, Sruthi, Torrente Gonçalves, Mariana, Kawalerski, Ryan R., K. Bai, Ji Dong, Chang, David K., Biankin, Andrew V., Scampavia, Louis, Spicer, Timothy, Escobar‐Hoyos, Luisa F., Shroyer, Kenneth R.
Publicado 2020

Gain-of-Signal Assays for Probing Inhibition of SARS-CoV-2 M(pro)/3CL(pro) in Living Cells

por Moghadasi, Seyed Arad, Esler, Morgan A., Otsuka, Yuka, Becker, Jordan T., Moraes, Sofia N., Anderson, Constance B., Chamakuri, Srinivas, Belica, Christopher, Wick, Chloe, Harki, Daniel A., Young, Damian W., Scampavia, Louis, Spicer, Timothy P., Shi, Ke, Aihara, Hideki, Brown, William L., Harris, Reuben S.
Publicado 2022