2159. Analysis of Resistance to Oral Standard-of-Care Antibiotics for Urinary Tract Infections Caused By Escherichia coli and Staphylococcus saprophyticus Collected in the United S...

por Arends, S J Ryan, Kapoor, Renuka, Torumkuney, Didem, Scangarella-Oman, Nicole E, Mendes, Rodrigo E
Publicado 2023

In Vitro Activity of Gepotidacin against Gram-Negative and Gram-Positive Anaerobes

por Hackel, Meredith A., Karlowsky, James A., Canino, Michele A., Sahm, Daniel F., Scangarella-Oman, Nicole E.
Publicado 2022

Dose selection for a phase III study evaluating gepotidacin (GSK2140944) in the treatment of uncomplicated urogenital gonorrhoea

por Scangarella-Oman, Nicole E, Hossain, Mohammad, Perry, Caroline R, Tiffany, Courtney, Powell, Marcy, Swift, Brandon, Dumont, Etienne F
Publicado 2023

Dose Selection for Phase III Clinical Evaluation of Gepotidacin (GSK2140944) in the Treatment of Uncomplicated Urinary Tract Infections

por Scangarella-Oman, Nicole E., Hossain, Mohammad, Hoover, Jennifer L., Perry, Caroline R., Tiffany, Courtney, Barth, Aline, Dumont, Etienne F.
Publicado 2022

Efficacy and Safety of Gepotidacin as Treatment of Uncomplicated Urogenital Gonorrhea (EAGLE-1): Design of a Randomized, Comparator-Controlled, Phase 3 Study

por Perry, Caroline R., Scangarella-Oman, Nicole E., Millns, Helen, Flight, William, Gatsi, Sally, Jakielaszek, Charles, Janmohamed, Salim, Lewis, David A.
Publicado 2023

Antimicrobial Resistance Trends in Urine Escherichia coli Isolates From Adult and Adolescent Females in the United States From 2011 to 2019: Rising ESBL Strains and Impact on Patie...

por Kaye, Keith S, Gupta, Vikas, Mulgirigama, Aruni, Joshi, Ashish V, Scangarella-Oman, Nicole E, Yu, Kalvin, Ye, Gang, Mitrani-Gold, Fanny S
Publicado 2021

2226. Analysis of Co-Resistance Among Klebsiella pneumoniae Urine Isolates From Female Outpatients in the United States

por Kaye, Keith S, Gupta, Vikas, Mulgirigama, Aruni, Joshi, Ashish V, Scangarella-Oman, Nicole E, Yu, Kalvin, Watts, Janet, Mitrani-Gold, Fanny S
Publicado 2022

2225. Analysis of Co-Resistance Among Escherichia coli Urine Isolates From Female Outpatients in the United States

por Kaye, Keith S, Gupta, Vikas, Mulgirigama, Aruni, Joshi, Ashish V, Scangarella-Oman, Nicole E, Yu, Kalvin, Watts, Janet, Mitrani-Gold, Fanny S
Publicado 2022

2837. Impact of Regulatory Guidelines on Therapeutic, Clinical, and Microbiological Success Rates in Uncomplicated Urinary Tract Infection: Results from a Two Phase 3 Randomized Co...

por Wagenlehner, Florian, Perry, Caroline R, Hooton, Thomas M, Scangarella-Oman, Nicole E, Millns, Helen, Jarvis, Emily, Dennison, Jeremy, Sheets, Amanda, Janmohamed, Salim
Publicado 2023

2832. Gepotidacin Efficacy in E. coli Drug-Resistant Phenotypes: A Pooled Analysis of the EAGLE-2 and EAGLE-3 Randomized Controlled Trials in Uncomplicated Urinary Tract Infection

por Hooton, Thomas M, Perry, Caroline R, Janmohamed, Salim, Sheets, Amanda, Dennison, Jeremy, Millns, Helen, Jarvis, Emily, Scangarella-Oman, Nicole E, Huang, Chun
Publicado 2023

Phase 2a Pharmacokinetic, Safety, and Exploratory Efficacy Evaluation of Oral Gepotidacin (GSK2140944) in Female Participants with Uncomplicated Urinary Tract Infection (Acute Unco...

por Overcash, J. Scott, Tiffany, Courtney A., Scangarella-Oman, Nicole E., Perry, Caroline R., Tao, Yu, Hossain, Mohammad, Barth, Aline, Dumont, Etienne F.
Publicado 2020

Microbiome recovery in adult females with uncomplicated urinary tract infections in a randomised phase 2A trial of the novel antibiotic gepotidacin (GSK140944)

por Nuzzo, Andrea, Van Horn, Stephanie, Traini, Christopher, Perry, Caroline R., Dumont, Etienne F., Scangarella-Oman, Nicole E., Gardiner, David F., Brown, James R.
Publicado 2021

Correction to: Microbiome recovery in adult females with uncomplicated urinary tract infections in a randomised phase 2A trial of the novel antibiotic gepotidacin (GSK2140944)

por Nuzzo, Andrea, Van Horn, Stephanie, Traini, Christopher, Perry, Caroline R., Dumont, Etienne F., Scangarella-Oman, Nicole E., Gardiner, David F., Brown, James R.
Publicado 2021

Older patient age and prior antimicrobial use strongly predict antimicrobial resistance in Escherichia coli isolates recovered from urinary tract infections among female outpatient...

por Mitrani-Gold, Fanny S., Kaye, Keith S., Gupta, Vikas, Mulgirigama, Aruni, Trautner, Barbara W., Scangarella-Oman, Nicole E., Yu, Kalvin C., Ye, Gang, Joshi, Ashish V.
Publicado 2023

Relationship between Gepotidacin Exposure and Prevention of On-Therapy Resistance Amplification in a Neisseria gonorrhoeae Hollow-Fiber In Vitro Infection Model

por VanScoy, Brian D., Scangarella-Oman, Nicole E., Fikes, Steven, Min, Sharon, Huang, Jianzhong, Ingraham, Karen, Bhavnani, Sujata M., Conde, Haley, Ambrose, Paul G.
Publicado 2020

Gepotidacin Pharmacokinetics-Pharmacodynamics against Escherichia coli in the One-Compartment and Hollow-Fiber In Vitro Infection Model Systems

por VanScoy, Brian D., Lakota, Elizabeth A., Conde, Haley, Fikes, Steven, Bhavnani, Sujata M., Elefante, Philippa B., Scangarella-Oman, Nicole E., Ambrose, Paul G.
Publicado 2021

P31 Efficacy and safety of oral gepotidacin in the treatment of uncomplicated urinary tract infection: results of two randomized, multicentre Phase 3 trials (EAGLE-2 and EAGLE-3)

por Wagenlehner, Florian, Perry, Caroline R, Hooton, Thomas M, Scangarella-Oman, Nicole E, Millns, Helen, (Ed) Feng, Hwa-ping, Powell, Marcy, Jarvis, Emily, Dennison, Jeremy, Sheets, Amanda, Butler, Deborah, Breton, John, Janmohamed, Salim
Publicado 2023

Gepotidacin for the Treatment of Uncomplicated Urogenital Gonorrhea: A Phase 2, Randomized, Dose-Ranging, Single-Oral Dose Evaluation

por Taylor, Stephanie N, Morris, David H, Avery, Ann K, Workowski, Kimberly A, Batteiger, Byron E, Tiffany, Courtney A, Perry, Caroline R, Raychaudhuri, Aparna, Scangarella-Oman, Nicole E, Hossain, Mohammad, Dumont, Etienne F
Publicado 2018

Microbiological Analysis from a Phase 2 Randomized Study in Adults Evaluating Single Oral Doses of Gepotidacin in the Treatment of Uncomplicated Urogenital Gonorrhea Caused by Neis...

por Scangarella-Oman, Nicole E., Hossain, Mohammad, Dixon, Paula B., Ingraham, Karen, Min, Sharon, Tiffany, Courtney A., Perry, Caroline R., Raychaudhuri, Aparna, Dumont, Etienne F., Huang, Jianzhong, Hook, Edward W., Miller, Linda A.
Publicado 2018

In Vitro Activity and Microbiological Efficacy of Gepotidacin from a Phase 2, Randomized, Multicenter, Dose-Ranging Study in Patients with Acute Bacterial Skin and Skin Structure I...

por Scangarella-Oman, Nicole E., Ingraham, Karen A., Tiffany, Courtney A., Tomsho, Lynn, Van Horn, Stephanie F., Mayhew, David N., Perry, Caroline R., Ashton, Theresa C., Dumont, Etienne F., Huang, Jianzhong, Brown, James R., Miller, Linda A.
Publicado 2020