Targeting Bacterial Dsb Proteins for the Development of Anti-Virulence Agents

por Smith, Roxanne P., Paxman, Jason J., Scanlon, Martin J., Heras, Begoña
Publicado 2016

The Fragment-Based Development of a Benzofuran Hit as a New Class of Escherichia coli DsbA Inhibitors

por Duncan, Luke F., Wang, Geqing, Ilyichova, Olga V., Scanlon, Martin J., Heras, Begoña, Abbott, Belinda M.
Publicado 2019

Sent packing: protein engineering generates a new crystal form of Pseudomonas aeruginosa DsbA1 with increased catalytic surface accessibility

por McMahon, Roisin M., Coinçon, Mathieu, Tay, Stephanie, Heras, Begoña, Morton, Craig J., Scanlon, Martin J., Martin, Jennifer L.
Publicado 2015

Binding of a pyrimidine RNA base-mimic to SARS-CoV-2 nonstructural protein 9

por Littler, Dene R., Mohanty, Biswaranjan, Lowery, Shea A., Colson, Rhys N., Gully, Benjamin S., Perlman, Stanley, Scanlon, Martin J., Rossjohn, Jamie
Publicado 2021

Distinct binding properties of TIAR RRMs and linker region

por Kim, Henry S., Headey, Stephen J., Yoga, Yano M.K., Scanlon, Martin J., Gorospe, Myriam, Wilce, Matthew C.J., Wilce, Jacqueline A.
Publicado 2013

Inhibition of Diverse DsbA Enzymes in Multi-DsbA Encoding Pathogens

por Totsika, Makrina, Vagenas, Dimitrios, Paxman, Jason J., Wang, Geqing, Dhouib, Rabeb, Sharma, Pooja, Martin, Jennifer L, Scanlon, Martin J., Heras, Begoña
Publicado 2018

Fragment-Based Discovery of Inhibitors of the Bacterial DnaG-SSB Interaction

por Chilingaryan, Zorik, Headey, Stephen J., Lo, Allen T. Y., Xu, Zhi-Qiang, Otting, Gottfried, Dixon, Nicholas E., Scanlon, Martin J., Oakley, Aaron J.
Publicado 2018

Methyl probes in proteins for determining ligand binding mode in weak protein–ligand complexes

por Mohanty, Biswaranjan, Orts, Julien, Wang, Geqing, Nebl, Stefan, Alwan, Wesam S., Doak, Bradley C., Williams, Martin L., Heras, Begoña, Mobli, Mehdi, Scanlon, Martin J.
Publicado 2022

Molecular Insights into the Interaction between Plasmodium falciparum Apical Membrane Antigen 1 and an Invasion-Inhibitory Peptide

por Wang, Geqing, MacRaild, Christopher A., Mohanty, Biswaranjan, Mobli, Mehdi, Cowieson, Nathan P., Anders, Robin F., Simpson, Jamie S., McGowan, Sheena, Norton, Raymond S., Scanlon, Martin J.
Publicado 2014

Identification and characterization of two drug-like fragments that bind to the same cryptic binding pocket of Burkholderia pseudomallei DsbA

por Petit, Guillaume A., Mohanty, Biswaranjan, McMahon, Róisín M., Nebl, Stefan, Hilko, David H., Wilde, Karyn L., Scanlon, Martin J., Martin, Jennifer L., Halili, Maria A.
Publicado 2022

Comparative Sequence, Structure and Redox Analyses of Klebsiella pneumoniae DsbA Show That Anti-Virulence Target DsbA Enzymes Fall into Distinct Classes

por Kurth, Fabian, Rimmer, Kieran, Premkumar, Lakshmanane, Mohanty, Biswaranjan, Duprez, Wilko, Halili, Maria A., Shouldice, Stephen R., Heras, Begoña, Fairlie, David P., Scanlon, Martin J., Martin, Jennifer L.
Publicado 2013

Fragment library screening identifies hits that bind to the non-catalytic surface of Pseudomonas aeruginosa DsbA1

por Mohanty, Biswaranjan, Rimmer, Kieran, McMahon, Róisín M., Headey, Stephen J., Vazirani, Mansha, Shouldice, Stephen R., Coinçon, Mathieu, Tay, Stephanie, Morton, Craig J., Simpson, Jamie S., Martin, Jennifer L., Scanlon, Martin J.
Publicado 2017

The Role of Oxidoreductases in Determining the Function of the Neisserial Lipid A Phosphoethanolamine Transferase Required for Resistance to Polymyxin

por Piek, Susannah, Wang, Zhirui, Ganguly, Jhuma, Lakey, Adam M., Bartley, Stephanie N., Mowlaboccus, Shakeel, Anandan, Anandhi, Stubbs, Keith A., Scanlon, Martin J., Vrielink, Alice, Azadi, Parastoo, Carlson, Russell W., Kahler, Charlene M.
Publicado 2014

Novel small molecules that increase the susceptibility of Neisseria gonorrhoeae to cationic antimicrobial peptides by inhibiting lipid A phosphoethanolamine transferase

por Mullally, Christopher, Stubbs, Keith A, Thai, Van C, Anandan, Anandhi, Bartley, Stephanie, Scanlon, Martin J, Jarvis, Gary A, John, Constance M, Lim, Katherine Y L, Sullivan, Courtney M, Sarkar-Tyson, Mitali, Vrielink, Alice, Kahler, Charlene M
Publicado 2022

Conserved features in TamA enable interaction with TamB to drive the activity of the translocation and assembly module

por Selkrig, Joel, Belousoff, Matthew J., Headey, Stephen J., Heinz, Eva, Shiota, Takuya, Shen, Hsin-Hui, Beckham, Simone A., Bamert, Rebecca S., Phan, Minh-Duy, Schembri, Mark A., Wilce, Matthew C.J., Scanlon, Martin J., Strugnell, Richard A., Lithgow, Trevor
Publicado 2015

Selective Binding of Small Molecules to Vibrio cholerae DsbA Offers a Starting Point for the Design of Novel Antibacterials

por Wang, Geqing, Mohanty, Biswaranjan, Williams, Martin L., Doak, Bradley C., Dhouib, Rabeb, Totsika, Makrina, McMahon, Róisín M., Sharma, Gaurav, Zheng, Dan, Bentley, Matthew R., Ka‐Yan Chin, Yanni, Horne, James, Chalmers, David K., Heras, Begoña, Scanlon, Martin J.
Publicado 2022