The NRF2 transcriptional target, OSGIN1, contributes to monomethyl fumarate-mediated cytoprotection in human astrocytes

por Brennan, Melanie S., Matos, Maria F., Richter, Karl E., Li, Bing, Scannevin, Robert H.
Publicado 2017

Dimethyl Fumarate and Monoethyl Fumarate Exhibit Differential Effects on KEAP1, NRF2 Activation, and Glutathione Depletion In Vitro

por Brennan, Melanie S., Matos, Maria F., Li, Bing, Hronowski, Xiaoping, Gao, Benbo, Juhasz, Peter, Rhodes, Kenneth J., Scannevin, Robert H.
Publicado 2015

Dimethyl fumarate impairs differentiated B cells and fosters central nervous system integrity in treatment of multiple sclerosis

por Traub, Jan, Traffehn, Sarah, Ochs, Jasmin, Häusser‐Kinzel, Silke, Stephan, Schirin, Scannevin, Robert, Brück, Wolfgang, Metz, Imke, Weber, Martin S.
Publicado 2019

Non-clinical Pharmacology of YTX-7739: a Clinical Stage Stearoyl-CoA Desaturase Inhibitor Being Developed for Parkinson’s Disease

por Tardiff, Daniel F., Lucas, Matthew, Wrona, Iwona, Chang, Belle, Chung, Chee Yeun, Le Bourdonnec, Bertrand, Rhodes, Kenneth J., Scannevin, Robert H.
Publicado 2022

Patient-derived three-dimensional cortical neurospheres to model Parkinson’s disease

por Raja, Waseem K., Neves, Esther, Burke, Christopher, Jiang, Xin, Xu, Ping, Rhodes, Kenneth J., Khurana, Vikram, Scannevin, Robert H., Chung, Chee Yeun
Publicado 2022

Dimethyl fumarate improves white matter function following severe hypoperfusion: Involvement of microglia/macrophages and inflammatory mediators

por Fowler, Jill H, McQueen, Jamie, Holland, Philip R, Manso, Yasmina, Marangoni, Martina, Scott, Fiona, Chisholm, Emma, Scannevin, Robert H, Hardingham, Giles E, Horsburgh, Karen
Publicado 2017

Different Fumaric Acid Esters Elicit Distinct Pharmacologic Responses

por Wipke, Brian T., Hoepner, Robert, Strassburger-Krogias, Katrin, Thomas, Ankur M., Gianni, Davide, Szak, Suzanne, Brennan, Melanie S., Pistor, Maximilian, Gold, Ralf, Chan, Andrew, Scannevin, Robert H.
Publicado 2021

Fumarates modulate microglia activation through a novel HCAR2 signaling pathway and rescue synaptic dysregulation in inflamed CNS

por Parodi, Benedetta, Rossi, Silvia, Morando, Sara, Cordano, Christian, Bragoni, Alberto, Motta, Caterina, Usai, Cesare, Wipke, Brian T., Scannevin, Robert H., Mancardi, Giovanni L., Centonze, Diego, Kerlero de Rosbo, Nicole, Uccelli, Antonio
Publicado 2015

A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses α-Synuclein Toxicity

por Nuber, Silke, Chung, Chee Yeun, Tardiff, Daniel F., Bechade, Pascal A., McCaffery, Thomas D., Shimanaka, Kazuma, Choi, Jeonghoon, Chang, Belle, Raja, Waseem, Neves, Esther, Burke, Christopher, Jiang, Xin, Xu, Ping, Khurana, Vikram, Dettmer, Ulf, Fanning, Saranna, Rhodes, Kenneth J., Selkoe, Dennis J., Scannevin, Robert H.
Publicado 2022

Correction to: A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses α-Synuclein Toxicity

por Nuber, Silke, Chung, Chee Yeun, Tardiff, Daniel F., Bechade, Pascal A., McCaffery, Thomas D., Shimanaka, Kazuma, Choi, Jeonghoon, Chang, Belle, Raja, Waseem, Neves, Esther, Burke, Christopher, Jiang, Xin, Xu, Ping, Khurana, Vikram, Dettmer, Ulf, Fanning, Saranna, Rhodes, Kenneth J., Selkoe, Dennis J., Scannevin, Robert H.
Publicado 2022

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2

por Bell, Karen F.S., Al-Mubarak, Bashayer, Martel, Marc-André, McKay, Sean, Wheelan, Nicola, Hasel, Philip, Márkus, Nóra M., Baxter, Paul, Deighton, Ruth F., Serio, Andrea, Bilican, Bilada, Chowdhry, Sudhir, Meakin, Paul J., Ashford, Michael L.J., Wyllie, David J.A., Scannevin, Robert H., Chandran, Siddharthan, Hayes, John D., Hardingham, Giles E.
Publicado 2015

Potent PDZ-Domain PICK1 Inhibitors that Modulate Amyloid Beta-Mediated Synaptic Dysfunction

por Lin, Edward Y. S., Silvian, Laura F., Marcotte, Douglas J., Banos, Charles C., Jow, Flora, Chan, Timothy R., Arduini, Robert M., Qian, Fang, Baker, Darren P., Bergeron, Chris, Hession, Catherine A., Huganir, Richard L., Borenstein, Cassandra F., Enyedy, Istvan, Zou, Jinming, Rohde, Ellen, Wittmann, Marion, Kumaravel, Gnanasambandam, Rhodes, Kenneth J., Scannevin, Robert H., Dunah, Anthone W., Guckian, Kevin M.
Publicado 2018