A modified thymine for the synthesis of site-specific thymine-guanine DNA interstrand crosslinks

por Alzeer, Jawad, Schärer, Orlando D.
Publicado 2006

Repair of cisplatin-induced DNA interstrand crosslinks by a replication-independent pathway involving transcription-coupled repair and translesion synthesis

por Enoiu, Milica, Jiricny, Josef, Schärer, Orlando D.
Publicado 2012

Synthesis of structurally diverse major groove DNA interstrand crosslinks using three different aldehyde precursors

por Mukherjee, Shivam, Guainazzi, Angelo, Schärer, Orlando D.
Publicado 2014

Site-specific incorporation of N-(deoxyguanosin-8-yl)-2-acetylaminofluorene (dG-AAF) into oligonucleotides using modified ‘ultra-mild’ DNA synthesis

por Gillet, Ludovic C. J., Alzeer, Jawad, Schärer, Orlando D.
Publicado 2005

Nucleotide excision repair leaves a mark on chromatin: DNA damage detection in nucleosomes

por Apelt, Katja, Lans, Hannes, Schärer, Orlando D., Luijsterburg, Martijn S.
Publicado 2021

PARP Inhibition in Prostate Cancer With Homologous Recombination Repair Alterations

por von Werdt, Alexander, Brandt, Laura, Schärer, Orlando D., Rubin, Mark A.
Publicado 2021

Structure-dependent bypass of DNA interstrand crosslinks by translesion synthesis polymerases

por Ho, The Vinh, Guainazzi, Angelo, Derkunt, Semsi Burak, Enoiu, Milica, Schärer, Orlando D.
Publicado 2011

The structure and duplex context of DNA interstrand crosslinks affects the activity of DNA polymerase η

por Roy, Upasana, Mukherjee, Shivam, Sharma, Anjali, Frank, Ekaterina G., Schärer, Orlando D.
Publicado 2016

Bypass of DNA interstrand crosslinks by a Rev1–DNA polymerase ζ complex

por Bezalel-Buch, Rachel, Cheun, Young K, Roy, Upasana, Schärer, Orlando D, Burgers, Peter M
Publicado 2020

Single-molecule visualization reveals the damage search mechanism for the human NER protein XPC-RAD23B

por Cheon, Na Young, Kim, Hyun-Suk, Yeo, Jung-Eun, Schärer, Orlando D, Lee, Ja Yil
Publicado 2019

Lack of recognition by global-genome nucleotide excision repair accounts for the high mutagenicity and persistence of aristolactam-DNA adducts

por Sidorenko, Victoria S., Yeo, Jung-Eun, Bonala, Radha R., Johnson, Francis, Schärer, Orlando D., Grollman, Arthur P.
Publicado 2012

Domain swapping between FEN-1 and XPG defines regions in XPG that mediate nucleotide excision repair activity and substrate specificity

por Hohl, Marcel, Dunand-Sauthier, Isabelle, Staresincic, Lidija, Jaquier-Gubler, Pascale, Thorel, Fabrizio, Modesti, Mauro, Clarkson, Stuart G., Schärer, Orlando D.
Publicado 2007

Drosophila DNA polymerase theta utilizes both helicase-like and polymerase domains during microhomology-mediated end joining and interstrand crosslink repair

por Beagan, Kelly, Armstrong, Robin L., Witsell, Alice, Roy, Upasana, Renedo, Nikolai, Baker, Amy E., Schärer, Orlando D., McVey, Mitch
Publicado 2017

Polycarcin V induces DNA-damage response and enables the profiling of DNA-binding proteins

por Yue, Zongwei, Wu, Fan, Guo, Fusheng, Park, Jiyeong, Wang, Jin, Zhang, Liyun, Liao, Daohong, Li, Wenyang, Schärer, Orlando D, Lei, Xiaoguang
Publicado 2022

Mouse SLX4 Is a Tumor Suppressor that Stimulates the Activity of the Nuclease XPF-ERCC1 in DNA Crosslink Repair

por Hodskinson, Michael R.G., Silhan, Jan, Crossan, Gerry P., Garaycoechea, Juan I., Mukherjee, Shivam, Johnson, Christopher M., Schärer, Orlando D., Patel, Ketan J.
Publicado 2014

FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response

por Thompson, Elizabeth L., Yeo, Jung E., Lee, Eun-A, Kan, Yinan, Raghunandan, Maya, Wiek, Constanze, Hanenberg, Helmut, Schärer, Orlando D., Hendrickson, Eric A., Sobeck, Alexandra
Publicado 2017

SDE2 integrates into the TIMELESS-TIPIN complex to protect stalled replication forks

por Rageul, Julie, Park, Jennifer J., Zeng, Ping Ping, Lee, Eun-A, Yang, Jihyeon, Hwang, Sunyoung, Lo, Natalie, Weinheimer, Alexandra S., Schärer, Orlando D., Yeo, Jung-Eun, Kim, Hyungjin
Publicado 2020

Structural basis of the fanconi anemia-associated mutations within the FANCA and FANCG complex

por Jeong, Eunyoung, Lee, Seong-Gyu, Kim, Hyun-Suk, Yang, Jihyeon, Shin, Jinwoo, Kim, Youngran, Kim, Jihan, Schärer, Orlando D, Kim, Youngjin, Yeo, Jung-Eun, Kim, Ho Min, Cho, Yunje
Publicado 2020

Interconverting Conformations of Slipped-DNA Junctions Formed by Trinucleotide Repeats Affect Repair Outcome

por Slean, Meghan M., Reddy, Kaalak, Wu, Bin, Nichol Edamura, Kerrie, Kekis, Mariana, Nelissen, Frank H. T., Aspers, Ruud L. E. G., Tessari, Marco, Schärer, Orlando D., Wijmenga, Sybren S., Pearson, Christopher E.
Publicado 2013

Alkylation of nucleobases by 2-chloro-N,N-diethylethanamine hydrochloride (CDEAH) sensitizes PARP1-deficient tumors

por Wie, Minwoo, Khim, Keon Woo, Groehler IV, Arnold S, Heo, Soomin, Woo, Junhyeok, Son, Kook, Lee, Eun A, Ra, Jae Sun, Hong, Sung You, Schärer, Orlando D, Choi, Jang Hyun, Myung, Kyungjae
Publicado 2023