Hemolysis, free hemoglobin toxicity, and scavenger protein therapeutics

por Vallelian, Florence, Buehler, Paul W., Schaer, Dominik J.
Publicado 2022

Spatial transcriptome data from coronal mouse brain sections after striatal injection of heme and heme-hemopexin

por Akeret, Kevin, Hugelshofer, Michael, Schaer, Dominik J., Buzzi, Raphael M.
Publicado 2022

Extensive chronic xanthogranulomatous intra-abdominal inflammation due to Mycoplasma hominis mimicking a malignancy: a case report

por Biedermann, Luc, Schaer, Dominik J, Montani, Matteo, Speich, Rudolf, Müllhaupt, Beat
Publicado 2009

Transcriptome Analysis Revealed Unique Genes as Targets for the Anti-inflammatory Action of Activated Protein C in Human Macrophages

por Pereira, Claudia P., Bachli, Esther B., Schaer, Dominik J., Schoedon, Gabriele
Publicado 2010

Chloroquine Interference with Hemoglobin Endocytic Trafficking Suppresses Adaptive Heme and Iron Homeostasis in Macrophages: The Paradox of an Antimalarial Agent

por Schaer, Christian A., Laczko, Endre, Schoedon, Gabriele, Schaer, Dominik J., Vallelian, Florence
Publicado 2013

Haptoglobin, hemopexin, and related defense pathways—basic science, clinical perspectives, and drug development

por Schaer, Dominik J., Vinchi, Francesca, Ingoglia, Giada, Tolosano, Emanuela, Buehler, Paul W.
Publicado 2014

Human Plasma and Recombinant Hemopexins: Heme Binding Revisited

por Karnaukhova, Elena, Owczarek, Catherine, Schmidt, Peter, Schaer, Dominik J., Buehler, Paul W.
Publicado 2021

Haptoglobin Treatment for Aneurysmal Subarachnoid Hemorrhage: Review and Expert Consensus on Clinical Translation

por Galea, Ian, Bandyopadhyay, Soham, Bulters, Diederik, Humar, Rok, Hugelshofer, Michael, Schaer, Dominik J.
Publicado 2023

Hemophagocytic macrophages constitute a major compartment of heme oxygenase expression in sepsis

por Schaer, Dominik J, Schaer, Christian A, Schoedon, Gabriele, Imhof, Alexander, Kurrer, Michael O
Publicado 2006

Modeling hemoglobin and hemoglobin:haptoglobin complex clearance in a non-rodent species–pharmacokinetic and therapeutic implications

por Boretti, Felicitas S., Baek, Jin Hyen, Palmer, Andre F., Schaer, Dominik J., Buehler, Paul W.
Publicado 2014

Extracellular Hb Enhances Cardiac Toxicity in Endotoxemic Guinea Pigs: Protective Role of Haptoglobin

por Baek, Jin Hyen, Zhang, Xiaoyuan, Williams, Matthew C., Schaer, Dominik J., Buehler, Paul W., D’Agnillo, Felice
Publicado 2014

Haptoglobin treatment prevents cell-free hemoglobin exacerbated mortality in experimental rat sepsis

por Schaer, Christian A., Jeger, Victor, Gentinetta, Thomas, Spahn, Donat R., Vallelian, Florence, Rudiger, Alain, Schaer, Dominik J.
Publicado 2021

Revisiting the putative role of heme as a trigger of inflammation

por Vallelian, Florence, Schaer, Christian A., Deuel, Jeremy W., Ingoglia, Giada, Humar, Rok, Buehler, Paul W., Schaer, Dominik J.
Publicado 2018

Acute Hemolysis and Heme Suppress Anti-CD40 Antibody-Induced Necro-Inflammatory Liver Disease

por Pfefferlé, Marc, Ingoglia, Giada, Schaer, Christian A., Hansen, Kerstin, Schulthess, Nadja, Humar, Rok, Schaer, Dominik J., Vallelian, Florence
Publicado 2021

Agonistic Anti-CD40 Antibody Triggers an Acute Liver Crisis With Systemic Inflammation in Humanized Sickle Cell Disease Mice

por Yalamanoglu, Ayla, Dubach, Irina L., Schulthess, Nadja, Ingoglia, Giada, Swindle, Delaney C., Humar, Rok, Schaer, Dominik J., Buehler, Paul W., Irwin, David C., Vallelian, Florence
Publicado 2021

The oral ferroportin inhibitor vamifeport improves hemodynamics in a mouse model of sickle cell disease

por Nyffenegger, Naja, Zennadi, Rahima, Kalleda, Natarajaswamy, Flace, Anna, Ingoglia, Giada, Buzzi, Raphael M., Doucerain, Cédric, Buehler, Paul W., Schaer, Dominik J., Dürrenberger, Franz, Manolova, Vania
Publicado 2022

Heme-stress activated NRF2 skews fate trajectories of bone marrow cells from dendritic cells towards red pulp-like macrophages in hemolytic anemia

por Vallelian, Florence, Buzzi, Raphael M., Pfefferlé, Marc, Yalamanoglu, Ayla, Dubach, Irina L., Wassmer, Andreas, Gentinetta, Thomas, Hansen, Kerstin, Humar, Rok, Schulthess, Nadja, Schaer, Christian A., Schaer, Dominik J.
Publicado 2022

MyD88-TLR4-dependent choroid plexus activation precedes perilesional inflammation and secondary brain edema in a mouse model of intracerebral hemorrhage

por Akeret, Kevin, Buzzi, Raphael M., Thomson, Bart R., Schwendinger, Nina, Klohs, Jan, Schulthess-Lutz, Nadja, Baselgia, Livio, Hansen, Kerstin, Regli, Luca, Vallelian, Florence, Hugelshofer, Michael, Schaer, Dominik J.
Publicado 2022

Iron deficiency and biomarkers of inflammation: a 3-year prospective analysis of the DO-HEALTH trial

por Wieczorek, Maud, Schwarz, Franziska, Sadlon, Angélique, Abderhalden, Lauren A., de Godoi Rezende Costa Molino, Caroline, Spahn, Donat R., Schaer, Dominik J., Orav, E. John, Egli, Andreas, Bischoff-Ferrari, Heike A.
Publicado 2021

Antibody-induced erythrophagocyte reprogramming of Kupffer cells prevents anti-CD40 cancer immunotherapy-associated liver toxicity

por Pfefferlé, Marc, Dubach, Irina L, Buzzi, Raphael M, Dürst, Elena, Schulthess-Lutz, Nadja, Baselgia, Livio, Hansen, Kerstin, Imhof, Larissa, Koernig, Sandra, Le Roy, Didier, Roger, Thierry, Humar, Rok, Schaer, Dominik J, Vallelian, Florence
Publicado 2023