Combination therapy of chemokine receptor inhibition plus PDL-1 blockade potentiates anti-tumor effects in a murine model of breast cancer

por Jung, Heiyoun, Bischof, Ashley, Ebsworth, Karen, Ertl, Linda, Schall, Thomas, Charo, Israel
Publicado 2015

The novel chemokine receptor CXCR7 regulates trans-endothelial migration of cancer cells

por Zabel, Brian A, Lewén, Susanna, Berahovich, Robert D, Jaén, Juan C, Schall, Thomas J
Publicado 2011

A Systemically-Administered Small Molecule Antagonist of CCR9 Acts as a Tissue-Selective Inhibitor of Lymphocyte Trafficking

por Tubo, Noah J., Wurbel, Marc A., Charvat, Trevor T., Schall, Thomas J., Walters, Matthew J., Campbell, James J.
Publicado 2012

Adjunctive Treatment With Avacopan, an Oral C5a Receptor Inhibitor, in Patients With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis

por Merkel, Peter A., Niles, John, Jimenez, Richard, Spiera, Robert F., Rovin, Brad H., Bomback, Andrew, Pagnoux, Christian, Potarca, Antonia, Schall, Thomas J., Bekker, Pirow
Publicado 2020

Structural basis of ligand interaction with atypical chemokine receptor 3

por Gustavsson, Martin, Wang, Liwen, van Gils, Noortje, Stephens, Bryan S., Zhang, Penglie, Schall, Thomas J., Yang, Sichun, Abagyan, Ruben, Chance, Mark R., Kufareva, Irina, Handel, Tracy M.
Publicado 2017

Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias

por Yen, Yu-Chen, Schafer, Christopher T., Gustavsson, Martin, Eberle, Stefanie A., Dominik, Pawel K., Deneka, Dawid, Zhang, Penglie, Schall, Thomas J., Kossiakoff, Anthony A., Tesmer, John J. G., Handel, Tracy M.
Publicado 2022

CCR9 Antagonists in the Treatment of Ulcerative Colitis

por Bekker, Pirow, Ebsworth, Karen, Walters, Matthew J., Berahovich, Robert D., Ertl, Linda S., Charvat, Trevor T., Punna, Sreenivas, Powers, Jay P., Campbell, James J., Sullivan, Timothy J., Jaen, Juan C., Schall, Thomas J.
Publicado 2015

CCR6, a CC Chemokine Receptor that Interacts with Macrophage Inflammatory Protein 3α and Is Highly Expressed in Human Dendritic Cells

por Greaves, David R., Wang, Wei, Dairaghi, Daniel J., Dieu, Marie Caroline, de Saint-Vis, Blandine, Franz-Bacon, Karin, Rossi, Devora, Caux, Christophe, McClanahan, Terrill, Gordon, Siamon, Zlotnik, Albert, Schall, Thomas J.
Publicado 1997

A Randomized Controlled Trial of the Efficacy and Safety of CCX282-B, an Orally-Administered Blocker of Chemokine Receptor CCR9, for Patients with Crohn’s Disease

por Keshav, Satish, Vaňásek, Tomáš, Niv, Yaron, Petryka, Robert, Howaldt, Stephanie, Bafutto, Mauro, Rácz, István, Hetzel, David, Nielsen, Ole Haagen, Vermeire, Séverine, Reinisch, Walter, Karlén, Per, Schreiber, Stefan, Schall, Thomas J., Bekker, Pirow
Publicado 2013

Characterization of Pharmacologic and Pharmacokinetic Properties of CCX168, a Potent and Selective Orally Administered Complement 5a Receptor Inhibitor, Based on Preclinical Evalua...

por Bekker, Pirow, Dairaghi, Daniel, Seitz, Lisa, Leleti, Manmohan, Wang, Yu, Ertl, Linda, Baumgart, Trageen, Shugarts, Sarah, Lohr, Lisa, Dang, Ton, Miao, Shichang, Zeng, Yibin, Fan, Pingchen, Zhang, Penglie, Johnson, Daniel, Powers, Jay, Jaen, Juan, Charo, Israel, Schall, Thomas J.
Publicado 2016

Enzalutamide and CXCR7 inhibitor combination treatment suppresses cell growth and angiogenic signaling in castration‐resistant prostate cancer models

por Luo, Yong, Azad, Abul Kalam, Karanika, Styliani, Basourakos, Spyridon P., Zuo, Xuemei, Wang, Jianxiang, Yang, Luan, Yang, Guang, Korentzelos, Dimitrios, Yin, Jianhua, Park, Sanghee, Zhang, Penglie, Campbell, James J., Schall, Thomas J., Cao, Guangwen, Li, Likun, Thompson, Timothy C.
Publicado 2018

Correction: Characterization of Pharmacologic and Pharmacokinetic Properties of CCX168, a Potent and Selective Orally Administered Complement 5a Receptor Inhibitor, Based on Precli...

por Bekker, Pirow, Dairaghi, Daniel, Seitz, Lisa, Leleti, Manmohan, Wang, Yu, Ertl, Linda, Baumgart, Trageen, Shugarts, Sarah, Lohr, Lisa, Dang, Ton, Miao, Shichang, Zeng, Yibin, Fan, Pingchen, Zhang, Penglie, Johnson, Daniel, Powers, Jay, Jaen, Juan, Charo, Israel, Schall, Thomas J.
Publicado 2019

A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development

por Burns, Jennifer M., Summers, Bretton C., Wang, Yu, Melikian, Anita, Berahovich, Rob, Miao, Zhenhua, Penfold, Mark E. T., Sunshine, Mary Jean, Littman, Dan R., Kuo, Calvin J., Wei, Kevin, McMaster, Brian E., Wright, Kim, Howard, Maureen C., Schall, Thomas J.
Publicado 2006

CCR2 antagonism leads to marked reduction in proteinuria and glomerular injury in murine models of focal segmental glomerulosclerosis (FSGS)

por Miao, Zhenhua, Ertl, Linda S., Newland, Dale, Zhao, Bin, Wang, Yu, Zang, Xiaoping, Campbell, James J., Liu, Xiaoli, Dang, Ton, Miao, Shichang, Krasinski, Antoni, Punna, Sreenivas, Zeng, Yibin, McMahon, Jeffrey, Zhang, Penglie, Charo, Israel F., Schall, Thomas J., Singh, Rajinder
Publicado 2018

Abrogation of CC chemokine receptor 9 ameliorates collagen-induced arthritis of mice

por Yokoyama, Waka, Kohsaka, Hitoshi, Kaneko, Kayoko, Walters, Matthew, Takayasu, Aiko, Fukuda, Shin, Miyabe, Chie, Miyabe, Yoshishige, Love, Paul E, Nakamoto, Nobuhiro, Kanai, Takanori, Watanabe-Imai, Kaori, Charvat, Trevor T, Penfold, Mark ET, Jaen, Juan, Schall, Thomas J, Harigai, Masayoshi, Miyasaka, Nobuyuki, Nanki, Toshihiro
Publicado 2014

CCX559 is a potent, orally-administered small molecule PD-L1 inhibitor that induces anti-tumor immunity

por Sullivan, Kathleen M. C., Vilalta, Marta, Ertl, Linda S., Wang, Yu, Dunlap, Carolyn, Ebsworth, Karen, Zhao, Bin N., Li, Shijie, Zeng, Yibin, Miao, Zhenhua, Fan, Pingchen, Mali, Venkat, Lange, Christopher, McMurtrie, Darren, Yang, Ju, Lui, Rebecca, Scamp, Ryan, Chhina, Vicky, Kumamoto, Alice, Yau, Simon, Dang, Ton, Easterday, Ashton, Liu, Shirley, Miao, Shichang, Charo, Israel, Schall, Thomas J., Zhang, Penglie
Publicado 2023

Cancer associated fibroblast FAK regulates malignant cell metabolism

por Demircioglu, Fevzi, Wang, Jun, Candido, Juliana, Costa, Ana S. H., Casado, Pedro, de Luxan Delgado, Beatriz, Reynolds, Louise E., Gomez-Escudero, Jesus, Newport, Emma, Rajeeve, Vinothini, Baker, Ann-Marie, Roy-Luzarraga, Marina, Graham, Trevor A., Foster, Julie, Wang, Yu, Campbell, James J., Singh, Rajinder, Zhang, Penglie, Schall, Thomas J., Balkwill, Frances R., Sosabowski, Jane, Cutillas, Pedro R., Frezza, Christian, Sancho, Patricia, Hodivala-Dilke, Kairbaan
Publicado 2020

ISN Nexus 2016 Symposia: Translational Immunology in Kidney Disease—The Berlin Roadmap

por Anders, Hans-Joachim, Rovin, Brad, Jayne, David, Brunetta, Paul, Coppo, Rosanna, Davidson, Anne, Devarapu, Satish Kumar, de Zeeuw, Dick, Duffield, Jeremy, Eulberg, Dirk, Fierro, Alberto, Floege, Jürgen, Frese, Steffen, Guillevin, Loïc, Holdsworth, Stephen, Hughes, Jeremy, Kettritz, Ralph, Kluger, Malte, Krebs, Christian, Lapteva, Larissa, Levin, Adeera, Li, Jinhua, Lightstone, Liz, Mack, Matthias, Mansouri, Ladan, McAdoo, Stephen, McKinney, Eoin, Panzer, Ulf, Parikh, Samir, Pusey, Charles, Putterman, Chaim, Rabelink, Ton, Radbruch, Andreas, Rees, Andrew, Reilly, Mary, Reinders, Marlies, Remuzzi, Giuseppe, Ruggenenti, Piero, Sacks, Steven, Schall, Thomas J, Meyer-Schwesinger, Catherine, Sharma, Kumar, Suzuki, Yusuke, Tomas, Nicola M., Zhao, Ming-Hui
Publicado 2016