Mutational analysis of SARS-CoV-2 variants of concern reveals key tradeoffs between receptor affinity and antibody escape

por Makowski, Emily K., Schardt, John S., Smith, Matthew D., Tessier, Peter M.
Publicado 2022

A platform of genetically engineered bacteria as vehicles for localized delivery of therapeutics: Toward applications for Crohn's disease

por McKay, Ryan, Ghodasra, Monil, Schardt, John, Quan, David, Pottash, Alex Eli, Shang, Wu, Jay, Steven M., Payne, Gregory F., Chang, Matthew Wook, March, John C., Bentley, William E.
Publicado 2018

Co-optimization of therapeutic antibody affinity and specificity using machine learning models that generalize to novel mutational space

por Makowski, Emily K., Kinnunen, Patrick C., Huang, Jie, Wu, Lina, Smith, Matthew D., Wang, Tiexin, Desai, Alec A., Streu, Craig N., Zhang, Yulei, Zupancic, Jennifer M., Schardt, John S., Linderman, Jennifer J., Tessier, Peter M.
Publicado 2022

Directed evolution of potent neutralizing nanobodies against SARS-CoV-2 using CDR-swapping mutagenesis

por Zupancic, Jennifer M., Desai, Alec A., Schardt, John S., Pornnoppadol, Ghasidit, Makowski, Emily K., Smith, Matthew D., Kennedy, Andrew A., Garcia de Mattos Barbosa, Mayara, Cascalho, Marilia, Lanigan, Thomas M., Tai, Andrew W., Tessier, Peter M.
Publicado 2021

Discovery and characterization of high-affinity, potent SARS-CoV-2 neutralizing antibodies via single B cell screening

por Schardt, John S., Pornnoppadol, Ghasidit, Desai, Alec A., Park, Kyung Soo, Zupancic, Jennifer M., Makowski, Emily K., Smith, Matthew D., Chen, Hongwei, Garcia de Mattos Barbosa, Mayara, Cascalho, Marilia, Lanigan, Thomas M., Moon, James J., Tessier, Peter M.
Publicado 2021