TCR/pMHC Optimized Protein crystallization Screen

por Bulek, Anna M., Madura, Florian, Fuller, Anna, Holland, Christopher J., Schauenburg, Andrea J.A., Sewell, Andrew K., Rizkallah, Pierre J., Cole, David K.
Publicado 2012

Structural basis for ineffective T-cell responses to MHC anchor residue-improved “heteroclitic” peptides

por Madura, Florian, Rizkallah, Pierre J, Holland, Christopher J, Fuller, Anna, Bulek, Anna, Godkin, Andrew J, Schauenburg, Andrea J, Cole, David K, Sewell, Andrew K
Publicado 2015

A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape

por Kløverpris, Henrik N, Cole, David K, Fuller, Anna, Carlson, Jonathan, Beck, Konrad, Schauenburg, Andrea J, Rizkallah, Pierre J, Buus, Søren, Sewell, Andrew K, Goulder, Philip
Publicado 2015

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens

por MacLachlan, Bruce J., Greenshields-Watson, Alexander, Mason, Georgina H, Schauenburg, Andrea J, Bianchi, Valentina, Rizkallah, Pierre J, Sewell, Andrew K, Fuller, Anna, Cole, David K
Publicado 2017

Enhanced Detection of Antigen-Specific CD4(+) T Cells Using Altered Peptide Flanking Residue Peptide–MHC Class II Multimers

por Holland, Christopher J., Dolton, Garry, Scurr, Martin, Ladell, Kristin, Schauenburg, Andrea J., Miners, Kelly, Madura, Florian, Sewell, Andrew K., Price, David A., Cole, David K., Godkin, Andrew J.
Publicado 2015

Metabolic Adaptation of Human CD4(+) and CD8(+) T-Cells to T-Cell Receptor-Mediated Stimulation

por Jones, Nicholas, Cronin, James G., Dolton, Garry, Panetti, Silvia, Schauenburg, Andrea J., Galloway, Sarah A. E., Sewell, Andrew K., Cole, David K., Thornton, Catherine A., Francis, Nigel J.
Publicado 2017

Genetic and Structural Basis for Selection of a Ubiquitous T Cell Receptor Deployed in Epstein-Barr Virus Infection

por Miles, John J., Bulek, Anna M., Cole, David K., Gostick, Emma, Schauenburg, Andrea J. A., Dolton, Garry, Venturi, Vanessa, Davenport, Miles P., Tan, Mai Ping, Burrows, Scott R., Wooldridge, Linda, Price, David A., Rizkallah, Pierre J., Sewell, Andrew K.
Publicado 2010

T-cell Receptor Specificity Maintained by Altered Thermodynamics

por Madura, Florian, Rizkallah, Pierre J., Miles, Kim M., Holland, Christopher J., Bulek, Anna M., Fuller, Anna, Schauenburg, Andrea J. A., Miles, John J., Liddy, Nathaniel, Sami, Malkit, Li, Yi, Hossain, Moushumi, Baker, Brian M., Jakobsen, Bent K., Sewell, Andrew K., Cole, David K.
Publicado 2013

Antibody Stabilization of Peptide–MHC Multimers Reveals Functional T Cells Bearing Extremely Low-Affinity TCRs

por Tungatt, Katie, Bianchi, Valentina, Crowther, Michael D., Powell, Wendy E., Schauenburg, Andrea J., Trimby, Andrew, Donia, Marco, Miles, John J., Holland, Christopher J., Cole, David K., Godkin, Andrew J., Peakman, Mark, Straten, Per Thor, Svane, Inge Marie, Sewell, Andrew K., Dolton, Garry
Publicado 2015

Identification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors

por Szomolay, Barbara, Liu, Jie, Brown, Paul E, Miles, John J, Clement, Mathew, Llewellyn-Lacey, Sian, Dolton, Garry, Ekeruche-Makinde, Julia, Lissina, Anya, Schauenburg, Andrea J, Sewell, Andrew K, Burrows, Scott R, Roederer, Mario, Price, David A, Wooldridge, Linda, van den Berg, Hugo A
Publicado 2016

Dual Molecular Mechanisms Govern Escape at Immunodominant HLA A2-Restricted HIV Epitope

por Cole, David K., Fuller, Anna, Dolton, Garry, Zervoudi, Efthalia, Legut, Mateusz, Miles, Kim, Blanchfield, Lori, Madura, Florian, Holland, Christopher J., Bulek, Anna M., Bridgeman, John S., Miles, John J., Schauenburg, Andrea J. A., Beck, Konrad, Evavold, Brian D., Rizkallah, Pierre J., Sewell, Andrew K.
Publicado 2017

T-cell Receptor (TCR)-Peptide Specificity Overrides Affinity-enhancing TCR-Major Histocompatibility Complex Interactions

por Cole, David K., Miles, Kim M., Madura, Florian, Holland, Christopher J., Schauenburg, Andrea J. A., Godkin, Andrew J., Bulek, Anna M., Fuller, Anna, Akpovwa, Hephzibah J. E., Pymm, Phillip G., Liddy, Nathaniel, Sami, Malkit, Li, Yi, Rizkallah, Pierre J., Jakobsen, Bent K., Sewell, Andrew K.
Publicado 2014

Structural Mechanism Underpinning Cross-reactivity of a CD8(+) T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase

por Cole, David K., van den Berg, Hugo A., Lloyd, Angharad, Crowther, Michael D., Beck, Konrad, Ekeruche-Makinde, Julia, Miles, John J., Bulek, Anna M., Dolton, Garry, Schauenburg, Andrea J., Wall, Aaron, Fuller, Anna, Clement, Mathew, Laugel, Bruno, Rizkallah, Pierre J., Wooldridge, Linda, Sewell, Andrew K.
Publicado 2017

TCR‐induced alteration of primary MHC peptide anchor residue

por Madura, Florian, Rizkallah, Pierre J., Legut, Mateusz, Holland, Christopher J., Fuller, Anna, Bulek, Anna, Schauenburg, Andrea J., Trimby, Andrew, Hopkins, Jade R., Wells, Stephen A., Godkin, Andrew, Miles, John J., Sami, Malkit, Li, Yi, Liddy, Nathaniel, Jakobsen, Bent K., Loveridge, E. Joel, Cole, David K., Sewell, Andrew K.
Publicado 2019

CD4(+) T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features

por Greenshields-Watson, Alexander, Attaf, Meriem, MacLachlan, Bruce J., Whalley, Thomas, Rius, Cristina, Wall, Aaron, Lloyd, Angharad, Hughes, Hywel, Strange, Kathryn E., Mason, Georgina H., Schauenburg, Andrea J., Hulin-Curtis, Sarah L., Geary, James, Chen, Yuan, Lauder, Sarah N., Smart, Kathryn, Vijaykrishna, Dhanasekaran, Grau, Miguel L., Shugay, Mikhail, Andrews, Robert, Dolton, Garry, Rizkallah, Pierre J., Gallimore, Awen M., Sewell, Andrew K., Godkin, Andrew J., Cole, David K.
Publicado 2020