Positive Selection at Key Residues in the HIV Envelope Distinguishes Broad and Strain-Specific Plasma Neutralizing Antibodies

por Mabvakure, Batsirai M., Scheepers, Cathrine, Garrett, Nigel, Abdool Karim, Salim, Williamson, Carolyn, Morris, Lynn, Moore, Penny L.
Publicado 2019

Advancing HIV Vaccine Research With Low-Cost High-Performance Computing Infrastructure: An Alternative Approach for Resource-Limited Settings

por Mabvakure, Batsirai M, Rott, Raymond, Dobrowsky, Leslie, Van Heusden, Peter, Morris, Lynn, Scheepers, Cathrine, Moore, Penny L
Publicado 2019

OGRDB: a reference database of inferred immune receptor genes

por Lees, William, Busse, Christian E, Corcoran, Martin, Ohlin, Mats, Scheepers, Cathrine, Matsen, Frederick A, Yaari, Gur, Watson, Corey T, Collins, Andrew, Shepherd, Adrian J
Publicado 2020

Sequence and functional characterization of a public HIV-specific antibody clonotype

por Murji, Amyn A., Raju, Nagarajan, Qin, Juliana S., Kaldine, Haajira, Janowska, Katarzyna, Fechter, Emilee Friedman, Mapengo, Rutendo, Scheepers, Cathrine, Setliff, Ian, Acharya, Priyamvada, Morris, Lynn, Georgiev, Ivelin S.
Publicado 2021

Dependence on a variable residue limits the breadth of an HIV MPER neutralizing antibody, despite convergent evolution with broadly neutralizing antibodies

por Scheepers, Cathrine, Kgagudi, Prudence, Mzindle, Nonkululeko, Gray, Elin S., Moyo-Gwete, Thandeka, Lambson, Bronwen E., Oosthuysen, Brent, Mabvakure, Batsirai, Garrett, Nigel J., Abdool Karim, Salim S., Morris, Lynn, Moore, Penny L.
Publicado 2022

IgG3 enhances neutralization potency and Fc effector function of an HIV V2-specific broadly neutralizing antibody

por Richardson, Simone I., Lambson, Bronwen E., Crowley, Andrew R., Bashirova, Arman, Scheepers, Cathrine, Garrett, Nigel, Abdool Karim, Salim, Mkhize, Nonhlanhla N., Carrington, Mary, Ackerman, Margaret E., Moore, Penny L., Morris, Lynn
Publicado 2019

Enhanced neutralization potency of an identical HIV neutralizing antibody expressed as different isotypes is achieved through genetically distinct mechanisms

por Moyo-Gwete, Thandeka, Scheepers, Cathrine, Makhado, Zanele, Kgagudi, Prudence, Mzindle, Nonkululeko B., Ziki, Rutendo, Madzorera, Sharon, Manamela, Nelia P., Ayres, Frances, Lambson, Bronwen E., Richardson, Simone I., Morris, Lynn, Moore, Penny L.
Publicado 2022

Multi-Donor Longitudinal Antibody Repertoire Sequencing Reveals the Existence of Public Antibody Clonotypes in HIV-1 Infection

por Setliff, Ian, McDonnell, Wyatt J., Raju, Nagarajan, Bombardi, Robin G., Murji, Amyn A., Scheepers, Cathrine, Ziki, Rutendo, Mynhardt, Charissa, Shepherd, Bryan E., Mamchak, Alusha A., Garrett, Nigel, Karim, Salim Abdool, Mallal, Simon A., Crowe, James E., Morris, Lynn, Georgiev, Ivelin S.
Publicado 2018

SARS-CoV-2 genomic surveillance in wastewater as a model for monitoring evolution of endemic viruses

por Yousif, Mukhlid, Rachida, Said, Taukobong, Setshaba, Ndlovu, Nkosenhle, Iwu-Jaja, Chinwe, Howard, Wayne, Moonsamy, Shelina, Mhlambi, Nompilo, Gwala, Sipho, Levy, Joshua I., Andersen, Kristian G., Scheepers, Cathrine, von Gottberg, Anne, Wolter, Nicole, Bhiman, Jinal N., Amoako, Daniel Gyamfi, Ismail, Arshad, Suchard, Melinda, McCarthy, Kerrigan
Publicado 2023

Antibody Isotype Switching as a Mechanism to Counter HIV Neutralization Escape

por Scheepers, Cathrine, Bekker, Valerie, Anthony, Colin, Richardson, Simone I., Oosthuysen, Brent, Moyo, Thandeka, Kgagudi, Prudence, Kitchin, Dale, Nonyane, Molati, York, Talita, Mielke, Dieter, Mabvakure, Batsirai M., Sheng, Zizhang, Lambson, Bronwen E., Ismail, Arshad, Garrett, Nigel J., Karim, Salim S. Abdool, Shapiro, Lawrence, Williamson, Carolyn, Morris, Lynn, Moore, Penny L.
Publicado 2020

Inferred Allelic Variants of Immunoglobulin Receptor Genes: A System for Their Evaluation, Documentation, and Naming

por Ohlin, Mats, Scheepers, Cathrine, Corcoran, Martin, Lees, William D., Busse, Christian E., Bagnara, Davide, Thörnqvist, Linnea, Bürckert, Jean-Philippe, Jackson, Katherine J. L., Ralph, Duncan, Schramm, Chaim A., Marthandan, Nishanth, Breden, Felix, Scott, Jamie, Matsen IV, Frederick A., Greiff, Victor, Yaari, Gur, Kleinstein, Steven H., Christley, Scott, Sherkow, Jacob S., Kossida, Sofia, Lefranc, Marie-Paule, van Zelm, Menno C., Watson, Corey T., Collins, Andrew M.
Publicado 2019

Early assessment of the clinical severity of the SARS-CoV-2 omicron variant in South Africa: a data linkage study

por Wolter, Nicole, Jassat, Waasila, Walaza, Sibongile, Welch, Richard, Moultrie, Harry, Groome, Michelle, Amoako, Daniel Gyamfi, Everatt, Josie, Bhiman, Jinal N, Scheepers, Cathrine, Tebeila, Naume, Chiwandire, Nicola, du Plessis, Mignon, Govender, Nevashan, Ismail, Arshad, Glass, Allison, Mlisana, Koleka, Stevens, Wendy, Treurnicht, Florette K, Makatini, Zinhle, Hsiao, Nei-yuan, Parboosing, Raveen, Wadula, Jeannette, Hussey, Hannah, Davies, Mary-Ann, Boulle, Andrew, von Gottberg, Anne, Cohen, Cheryl
Publicado 2022

V2-Directed Vaccine-like Antibodies from HIV-1 Infection Identify an Additional K169-Binding Light Chain Motif with Broad ADCC Activity

por van Eeden, Charmaine, Kurt Wibmer, Constantinos, Scheepers, Cathrine, Richardson, Simone I., Nonyane, Molati, Lambson, Bronwen, Mkhize, Nonhlanhla N., Vijayakumar, Balakrishnan, Sheng, Zizhang, Stanfield-Oakley, Sherry, Bhiman, Jinal N., Bekker, Valerie, Hermanus, Tandile, Mabvakure, Batsirai, Ismail, Arshad, Moody, M. Anthony, Wiehe, Kevin, Garrett, Nigel, Karim, Salim Abdool, Dirr, Heini, Fernandes, Manuel A., Sayed, Yasien, Shapiro, Lawrence, Ferrari, Guido, Haynes, Barton F., Moore, Penny L., Morris, Lynn
Publicado 2018

Clinical severity of SARS-CoV-2 Omicron BA.4 and BA.5 lineages compared to BA.1 and Delta in South Africa

por Wolter, Nicole, Jassat, Waasila, Walaza, Sibongile, Welch, Richard, Moultrie, Harry, Groome, Michelle J., Amoako, Daniel Gyamfi, Everatt, Josie, Bhiman, Jinal N., Scheepers, Cathrine, Tebeila, Naume, Chiwandire, Nicola, du Plessis, Mignon, Govender, Nevashan, Ismail, Arshad, Glass, Allison, Mlisana, Koleka, Stevens, Wendy, Treurnicht, Florette K., Subramoney, Kathleen, Makatini, Zinhle, Hsiao, Nei-yuan, Parboosing, Raveen, Wadula, Jeannette, Hussey, Hannah, Davies, Mary-Ann, Boulle, Andrew, von Gottberg, Anne, Cohen, Cheryl
Publicado 2022

SARS-CoV-2 Omicron has extensive but incomplete escape of Pfizer BNT162b2 elicited neutralization and requires ACE2 for infection

por Cele, Sandile, Jackson, Laurelle, Khoury, David S., Khan, Khadija, Moyo-Gwete, Thandeka, Tegally, Houriiyah, San, James Emmanuel, Cromer, Deborah, Scheepers, Cathrine, Amoako, Daniel, Karim, Farina, Bernstein, Mallory, Lustig, Gila, Archary, Derseree, Smith, Muneerah, Ganga, Yashica, Jule, Zesuliwe, Reedoy, Kajal, Hwa, Shi-Hsia, Giandhari, Jennifer, Blackburn, Jonathan M., Gosnell, Bernadett I., Abdool Karim, Salim S., Hanekom, Willem, von Gottberg, Anne, Bhiman, Jinal, Lessells, Richard J., Moosa, Mahomed-Yunus S., Davenport, Miles P., de Oliveira, Tulio, Moore, Penny L., Sigal, Alex
Publicado 2021

Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization

por Cele, Sandile, Jackson, Laurelle, Khoury, David S., Khan, Khadija, Moyo-Gwete, Thandeka, Tegally, Houriiyah, San, James Emmanuel, Cromer, Deborah, Scheepers, Cathrine, Amoako, Daniel G., Karim, Farina, Bernstein, Mallory, Lustig, Gila, Archary, Derseree, Smith, Muneerah, Ganga, Yashica, Jule, Zesuliwe, Reedoy, Kajal, Hwa, Shi-Hsia, Giandhari, Jennifer, Blackburn, Jonathan M., Gosnell, Bernadett I., Abdool Karim, Salim S., Hanekom, Willem, von Gottberg, Anne, Bhiman, Jinal N., Lessells, Richard J., Moosa, Mahomed-Yunus S., Davenport, Miles P., de Oliveira, Tulio, Moore, Penny L., Sigal, Alex
Publicado 2021

Selection analysis identifies unusual clustered mutational changes in Omicron lineage BA.1 that likely impact Spike function

por Martin, Darren P, Lytras, Spyros, Lucaci, Alexander G, Maier, Wolfgang, Grüning, Björn, Shank, Stephen D, Weaver, Steven, MacLean, Oscar A, Orton, Richard J, Lemey, Philippe, Boni, Maciej F, Tegally, Houriiyah, Harkins, Gordon, Scheepers, Cathrine, Bhiman, Jinal N, Everatt, Josie, Amoako, Daniel G, San, James Emmanuel, Giandhari, Jennifer, Sigal, Alex, Williamson, Carolyn, Hsiao, Nei-yuan, von Gottberg, Anne, De Klerk, Arne, Shafer, Robert W, Robertson, David L, Wilkinson, Robert J, Sewell, B Trevor, Lessells, Richard, Nekrutenko, Anton, Greaney, Allison J., Starr, Tyler N., Bloom, Jesse D., Murrell, Ben, Wilkinson, Eduan, Gupta, Ravindra K, de Oliveira, Tulio, Kosakovsky Pond, Sergei L
Publicado 2022

Selection Analysis Identifies Clusters of Unusual Mutational Changes in Omicron Lineage BA.1 That Likely Impact Spike Function

por Martin, Darren P., Lytras, Spyros, Lucaci, Alexander G., Maier, Wolfgang, Grüning, Björn, Shank, Stephen D., Weaver, Steven, MacLean, Oscar A., Orton, Richard J., Lemey, Philippe, Boni, Maciej F., Tegally, Houriiyah, Harkins, Gordon W., Scheepers, Cathrine, Bhiman, Jinal N., Everatt, Josie, Amoako, Daniel G., San, James Emmanuel, Giandhari, Jennifer, Sigal, Alex, Williamson, Carolyn, Hsiao, Nei-yuan, von Gottberg, Anne, De Klerk, Arne, Shafer, Robert W., Robertson, David L., Wilkinson, Robert J., Sewell, B. Trevor, Lessells, Richard, Nekrutenko, Anton, Greaney, Allison J., Starr, Tyler N., Bloom, Jesse D., Murrell, Ben, Wilkinson, Eduan, Gupta, Ravindra K., de Oliveira, Tulio, Kosakovsky Pond, Sergei L.
Publicado 2022

Emergence and phenotypic characterization of the global SARS-CoV-2 C.1.2 lineage

por Scheepers, Cathrine, Everatt, Josie, Amoako, Daniel G., Tegally, Houriiyah, Wibmer, Constantinos Kurt, Mnguni, Anele, Ismail, Arshad, Mahlangu, Boitshoko, Lambson, Bronwen E., Martin, Darren P., Wilkinson, Eduan, San, James Emmanuel, Giandhari, Jennifer, Manamela, Nelia, Ntuli, Noxolo, Kgagudi, Prudence, Cele, Sandile, Richardson, Simone I., Pillay, Sureshnee, Mohale, Thabo, Ramphal, Upasana, Naidoo, Yeshnee, Khumalo, Zamantungwa T., Kwatra, Gaurav, Gray, Glenda, Bekker, Linda-Gail, Madhi, Shabir A., Baillie, Vicky, Van Voorhis, Wesley C., Treurnicht, Florette K., Venter, Marietjie, Mlisana, Koleka, Wolter, Nicole, Sigal, Alex, Williamson, Carolyn, Hsiao, Nei-yuan, Msomi, Nokukhanya, Maponga, Tongai, Preiser, Wolfgang, Makatini, Zinhle, Lessells, Richard, Moore, Penny L., de Oliveira, Tulio, von Gottberg, Anne, Bhiman, Jinal N.
Publicado 2022

Emergence of SARS-CoV-2 Omicron lineages BA.4 and BA.5 in South Africa

por Tegally, Houriiyah, Moir, Monika, Everatt, Josie, Giovanetti, Marta, Scheepers, Cathrine, Wilkinson, Eduan, Subramoney, Kathleen, Makatini, Zinhle, Moyo, Sikhulile, Amoako, Daniel G., Baxter, Cheryl, Althaus, Christian L., Anyaneji, Ugochukwu J., Kekana, Dikeledi, Viana, Raquel, Giandhari, Jennifer, Lessells, Richard J., Maponga, Tongai, Maruapula, Dorcas, Choga, Wonderful, Matshaba, Mogomotsi, Mbulawa, Mpaphi B., Msomi, Nokukhanya, Naidoo, Yeshnee, Pillay, Sureshnee, Sanko, Tomasz Janusz, San, James E., Scott, Lesley, Singh, Lavanya, Magini, Nonkululeko A., Smith-Lawrence, Pamela, Stevens, Wendy, Dor, Graeme, Tshiabuila, Derek, Wolter, Nicole, Preiser, Wolfgang, Treurnicht, Florette K., Venter, Marietjie, Chiloane, Georginah, McIntyre, Caitlyn, O’Toole, Aine, Ruis, Christopher, Peacock, Thomas P., Roemer, Cornelius, Kosakovsky Pond, Sergei L., Williamson, Carolyn, Pybus, Oliver G., Bhiman, Jinal N., Glass, Allison, Martin, Darren P., Jackson, Ben, Rambaut, Andrew, Laguda-Akingba, Oluwakemi, Gaseitsiwe, Simani, von Gottberg, Anne, de Oliveira, Tulio
Publicado 2022