Identification of the ER-resident E3 ubiquitin ligase RNF145 as a novel LXR-regulated gene

por Cook, Emma C. L., Nelson, Jessica K., Sorrentino, Vincenzo, Koenis, Duco, Moeton, Martina, Scheij, Saskia, Ottenhoff, Roelof, Bleijlevens, Boris, Loregger, Anke, Zelcer, Noam
Publicado 2017

EEPD1 Is a Novel LXR Target Gene in Macrophages Which Regulates ABCA1 Abundance and Cholesterol Efflux

por Nelson, Jessica Kristine, Koenis, Duco Steven, Scheij, Saskia, Cook, Emma Clare Laura, Moeton, Martina, Santos, Ana, Lobaccaro, Jean-Marc Adolphe, Baron, Silvere, Zelcer, Noam
Publicado 2017

Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis

por Loregger, Anke, Raaben, Matthijs, Tan, Josephine, Scheij, Saskia, Moeton, Martina, van den Berg, Marlene, Gelberg-Etel, Hila, Stickel, Elmer, Roitelman, Joseph, Brummelkamp, Thijn, Zelcer, Noam
Publicado 2017

Action myoclonus-renal failure syndrome: diagnostic applications of activity-based probes and lipid analysis

por Gaspar, Paulo, Kallemeijn, Wouter W., Strijland, Anneke, Scheij, Saskia, Van Eijk, Marco, Aten, Jan, Overkleeft, Herman S., Balreira, Andrea, Zunke, Friederike, Schwake, Michael, Sá Miranda, Clara, Aerts, Johannes M. F. G.
Publicado 2014

Investigations on therapeutic glucocerebrosidases through paired detection with fluorescent activity-based probes

por Kallemeijn, Wouter W., Scheij, Saskia, Hoogendoorn, Sascha, Witte, Martin D., Herrera Moro Chao, Daniela, van Roomen, Cindy P. A. A., Ottenhoff, Roelof, Overkleeft, Herman S., Boot, Rolf G., Aerts, Johannes M. F. G.
Publicado 2017

Inactivation of the E3 Ubiquitin Ligase IDOL Attenuates Diet-Induced Obesity and Metabolic Dysfunction in Mice

por van Loon, Nienke M., Ottenhoff, Roelof, Kooijman, Sander, Moeton, Martina, Scheij, Saskia, Roscam Abbing, Reinout L.P., Gijbels, Marion J.J., Levels, Johannes H.M., Sorrentino, Vincenzo, Berbée, Jimmy F.P., Rensen, Patrick C.N., Zelcer, Noam
Publicado 2018

HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution

por Tol, Marc J., van der Lienden, Martijn J.C., Gabriel, Tanit L., Hagen, Jacob J., Scheij, Saskia, Veenendaal, Tineke, Klumperman, Judith, Donker-Koopman, Wilma E., Verhoeven, Arthur J., Overkleeft, Hermen, Aerts, Johannes M., Argmann, Carmen A., van Eijk, Marco
Publicado 2018

A PPARγ-Bnip3 Axis Couples Adipose Mitochondrial Fusion-Fission Balance to Systemic Insulin Sensitivity

por Tol, Marc J., Ottenhoff, Roelof, van Eijk, Marco, Zelcer, Noam, Aten, Jan, Houten, Sander M., Geerts, Dirk, van Roomen, Cindy, Bierlaagh, Marlou C., Scheij, Saskia, Hoeksema, Marten A., Aerts, Johannes M., Bogan, Jonathan S., Dorn, Gerald W., Argmann, Carmen A., Verhoeven, Arthur J.
Publicado 2016

Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism

por Loregger, Anke, Raaben, Matthijs, Nieuwenhuis, Joppe, Tan, Josephine M. E., Jae, Lucas T., van den Hengel, Lisa G., Hendrix, Sebastian, van den Berg, Marlene, Scheij, Saskia, Song, Ji-Ying, Huijbers, Ivo J., Kroese, Lona J., Ottenhoff, Roelof, van Weeghel, Michel, van de Sluis, Bart, Brummelkamp, Thijn, Zelcer, Noam
Publicado 2020

Stabilization of Glucocerebrosidase by Active Site Occupancy

por Ben Bdira, Fredj, Kallemeijn, Wouter W., Oussoren, Saskia V., Scheij, Saskia, Bleijlevens, Boris, Florea, Bogdan I., van Roomen, Cindy P. A. A., Ottenhoff, Roelof, van Kooten, Marielle J. F. M., Walvoort, Marthe T. C., Witte, Martin D., Boot, Rolf G., Ubbink, Marcellus, Overkleeft, Herman S., Aerts, Johannes M. F. G.
Publicado 2017

In vitro and in vivo comparative and competitive activity-based protein profiling of GH29 α-l-fucosidases

por Jiang, Jianbing, Kallemeijn, Wouter W., Wright, Daniel W., van den Nieuwendijk, Adrianus M. C. H., Rohde, Veronica Coco, Folch, Elisa Colomina, van den Elst, Hans, Florea, Bogdan I., Scheij, Saskia, Donker-Koopman, Wilma E., Verhoek, Marri, Li, Nan, Schürmann, Martin, Mink, Daniel, Boot, Rolf G., Codée, Jeroen D. C., van der Marel, Gijsbert A., Davies, Gideon J., Aerts, Johannes M. F. G., Overkleeft, Herman S.
Publicado 2015

Glucosylated cholesterol in mammalian cells and tissues: formation and degradation by multiple cellular β-glucosidases

por Marques, André R. A., Mirzaian, Mina, Akiyama, Hisako, Wisse, Patrick, Ferraz, Maria J., Gaspar, Paulo, Ghauharali-van der Vlugt, Karen, Meijer, Rianne, Giraldo, Pilar, Alfonso, Pilar, Irún, Pilar, Dahl, Maria, Karlsson, Stefan, Pavlova, Elena V., Cox, Timothy M., Scheij, Saskia, Verhoek, Marri, Ottenhoff, Roelof, van Roomen, Cindy P. A. A., Pannu, Navraj S., van Eijk, Marco, Dekker, Nick, Boot, Rolf G., Overkleeft, Herman S., Blommaart, Edward, Hirabayashi, Yoshio, Aerts, Johannes M.
Publicado 2016