When designing vaccines, consider the starting material: the human B cell repertoire

por Havenar-Daughton, Colin, Abbott, Robert K., Schief, William R., Crotty, Shane
Publicado 2018

CoV3D: A database and resource for high resolution coronavirus protein structures

por Gowthaman, Ragul, Guest, Johnathan D., Yin, Rui, Adolf-Bryfogle, Jared, Schief, William R., Pierce, Brian G.
Publicado 2020

CoV3D: a database of high resolution coronavirus protein structures

por Gowthaman, Ragul, Guest, Johnathan D, Yin, Rui, Adolf-Bryfogle, Jared, Schief, William R, Pierce, Brian G
Publicado 2020

RosettaRemodel: A Generalized Framework for Flexible Backbone Protein Design

por Huang, Po-Ssu, Ban, Yih-En Andrew, Richter, Florian, Andre, Ingemar, Vernon, Robert, Schief, William R., Baker, David
Publicado 2011

Vaccine genetics of IGHV1-2 VRC01-class broadly neutralizing antibody precursor naïve human B cells

por Lee, Jeong Hyun, Toy, Laura, Kos, Justin T., Safonova, Yana, Schief, William R., Havenar-Daughton, Colin, Watson, Corey T., Crotty, Shane
Publicado 2021

Heterologous Epitope-Scaffold Prime∶Boosting Immuno-Focuses B Cell Responses to the HIV-1 gp41 2F5 Neutralization Determinant

por Guenaga, Javier, Dosenovic, Pia, Ofek, Gilad, Baker, David, Schief, William R., Kwong, Peter D., Karlsson Hedestam, Gunilla B., Wyatt, Richard T.
Publicado 2011

RosettaAntibodyDesign (RAbD): A general framework for computational antibody design

por Adolf-Bryfogle, Jared, Kalyuzhniy, Oleks, Kubitz, Michael, Weitzner, Brian D., Hu, Xiaozhen, Adachi, Yumiko, Schief, William R., Dunbrack, Roland L.
Publicado 2018

Automatically Fixing Errors in Glycoprotein Structures with Rosetta

por Frenz, Brandon, Rämisch, Sebastian, Borst, Andrew J., Walls, Alexandra C., Adolf-Bryfogle, Jared, Schief, William R., Veesler, David, DiMaio, Frank
Publicado 2019

An HIV-1 Envelope Glycoprotein Trimer with an Embedded IL-21 Domain Activates Human B Cells

por Isik, Gözde, Chung, Nancy P. Y., van Montfort, Thijs, Menis, Sergey, Matthews, Katie, Schief, William R., Moore, John P., Sanders, Rogier W.
Publicado 2013

Glycan Masking of Plasmodium vivax Duffy Binding Protein for Probing Protein Binding Function and Vaccine Development

por Sampath, Sowmya, Carrico, Chris, Janes, Joel, Gurumoorthy, Sairam, Gibson, Claire, Melcher, Martin, Chitnis, Chetan E., Wang, Ruobing, Schief, William R., Smith, Joseph D.
Publicado 2013

Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo

por Kato, Yu, Abbott, Robert K., Freeman, Brian L., Haupt, Sonya, Groschel, Bettina, Silva, Murillo, Menis, Sergey, Irvine, Darrell J., Schief, William R., Crotty, Shane
Publicado 2020

Modulating the quantity of HIV Env-specific CD4 T cell help promotes rare B cell responses in germinal centers

por Lee, Jeong Hyun, Hu, Joyce K., Georgeson, Erik, Nakao, Catherine, Groschel, Bettina, Dileepan, Thamotharampillai, Jenkins, Marc K., Seumois, Gregory, Vijayanand, Pandurangan, Schief, William R., Crotty, Shane
Publicado 2020

Computational Design of High-Affinity Epitope Scaffolds by Backbone Grafting of a Linear Epitope

por Azoitei, Mihai L., Ban, Yih-En Andrew, Julien, Jean-Philippe, Bryson, Steve, Schroeter, Alexandria, Kalyuzhniy, Oleksandr, Porter, Justin R., Adachi, Yumiko, Baker, David, Pai, Emil F., Schief, William R.
Publicado 2012

Role of nanoscale antigen organization on B-cell activation probed using DNA origami

por Veneziano, Rémi, Moyer, Tyson J., Stone, Matthew B., Wamhoff, Eike-Christian, Read, Benjamin J., Mukherjee, Sayak, Shepherd, Tyson R., Das, Jayajit, Schief, William R., Irvine, Darrell J., Bathe, Mark
Publicado 2020

Efficient isolation of rare B cells using next-generation antigen barcoding

por Hurtado, Jonathan, Flynn, Claudia, Lee, Jeong Hyun, Salcedo, Eugenia C., Cottrell, Christopher A., Skog, Patrick D., Burton, Dennis R., Nemazee, David, Schief, William R., Landais, Elise, Sok, Devin, Briney, Bryan
Publicado 2023

Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies

por McGuire, Andrew T., Hoot, Sam, Dreyer, Anita M., Lippy, Adriana, Stuart, Andrew, Cohen, Kristen W., Jardine, Joseph, Menis, Sergey, Scheid, Johannes F., West, Anthony P., Schief, William R., Stamatatos, Leonidas
Publicado 2013

One‐step CRISPR/Cas9 method for the rapid generation of human antibody heavy chain knock‐in mice

por Lin, Ying‐Cing, Pecetta, Simone, Steichen, Jon M, Kratochvil, Sven, Melzi, Eleonora, Arnold, Johan, Dougan, Stephanie K, Wu, Lin, Kirsch, Kathrin H, Nair, Usha, Schief, William R, Batista, Facundo D
Publicado 2018

Highly mutated antibodies capable of neutralizing N276 glycan-deficient HIV after a single immunization with an Env trimer

por Lee, Jeong Hyun, Nakao, Catherine, Appel, Michael, Le, Amber, Landais, Elise, Kalyuzhniy, Oleksandr, Hu, Xiaozhen, Liguori, Alessia, Mullen, Tina-Marie, Groschel, Bettina, Abbott, Robert K., Sok, Devin, Schief, William R., Crotty, Shane
Publicado 2022

Optimization of an alum-anchored clinical HIV vaccine candidate

por Rodrigues, Kristen A., Cottrell, Christopher A., Steichen, Jon M., Groschel, Bettina, Abraham, Wuhbet, Suh, Heikyung, Agarwal, Yash, Ni, Kaiyuan, Chang, Jason Y. H., Yousefpour, Parisa, Melo, Mariane B., Schief, William R., Irvine, Darrell J.
Publicado 2023

Enhancing Humoral Responses Against HIV Envelope Trimers via Nanoparticle Delivery with Stabilized Synthetic Liposomes

por Tokatlian, Talar, Kulp, Daniel W., Mutafyan, Andrew A., Jones, Christopher A., Menis, Sergey, Georgeson, Erik, Kubitz, Mike, Zhang, Michael H., Melo, Mariane B., Silva, Murillo, Yun, Dong Soo, Schief, William R., Irvine, Darrell J.
Publicado 2018