Natural Products from Plants and Algae for Treatment of Alzheimer’s Disease: A Review

por Klose, Jana, Griehl, Carola, Roßner, Steffen, Schilling, Stephan
Publicado 2022

Passive Aβ Immunotherapy: Current Achievements and Future Perspectives

por Schilling, Stephan, Rahfeld, Jens-Ulrich, Lues, Inge, Lemere, Cynthia A.
Publicado 2018

Intraneuronal pyroglutamate-Abeta 3–42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model

por Wirths, Oliver, Breyhan, Henning, Cynis, Holger, Schilling, Stephan, Demuth, Hans-Ulrich, Bayer, Thomas A.
Publicado 2009

Passive Immunization against Pyroglutamate-3 Amyloid-β Reduces Plaque Burden in Alzheimer-Like Transgenic Mice: A Pilot Study

por Frost, Jeffrey L., Liu, Bin, Kleinschmidt, Martin, Schilling, Stephan, Demuth, Hans-Ulrich, Lemere, Cynthia A.
Publicado 2012

Acute Effects of Focused Ultrasound-Induced Blood-Brain Barrier Opening on Anti-Pyroglu3 Abeta Antibody Delivery and Immune Responses

por Bathini, Praveen, Sun, Tao, Schenk, Mathias, Schilling, Stephan, McDannold, Nathan J., Lemere, Cynthia A.
Publicado 2022

Immunohistochemical Demonstration of the pGlu79 α-Synuclein Fragment in Alzheimer’s Disease and Its Tg2576 Mouse Model

por Bluhm, Alexandra, Schrempel, Sarah, Schilling, Stephan, von Hörsten, Stephan, Schulze, Anja, Roßner, Steffen, Hartlage-Rübsamen, Maike
Publicado 2022

Pathological Hallmarks, Clinical Parallels, and Value for Drug Testing in Alzheimer's Disease of the APP[V717I] London Transgenic Mouse Model

por Tanghe, An, Termont, Annelies, Merchiers, Pascal, Schilling, Stephan, Demuth, Hans-Ulrich, Scrocchi, Louise, Van Leuven, Fred, Griffioen, Gerard, Van Dooren, Tom
Publicado 2010

Development of the clinical candidate PBD-C06, a humanized pGlu3-Aβ-specific antibody against Alzheimer’s disease with reduced complement activation

por Hettmann, Thore, Gillies, Stephen D., Kleinschmidt, Martin, Piechotta, Anke, Makioka, Koki, Lemere, Cynthia A., Schilling, Stephan, Rahfeld, Jens-Ulrich, Lues, Inge
Publicado 2020

Structure and Dynamics of Meprin β in Complex with a Hydroxamate-Based Inhibitor

por Linnert, Miriam, Fritz, Claudia, Jäger, Christian, Schlenzig, Dagmar, Ramsbeck, Daniel, Kleinschmidt, Martin, Wermann, Michael, Demuth, Hans-Ulrich, Parthier, Christoph, Schilling, Stephan
Publicado 2021

Combination of the Glutaminyl Cyclase Inhibitor PQ912 (Varoglutamstat) and the Murine Monoclonal Antibody PBD-C06 (m6) Shows Additive Effects on Brain Aβ Pathology in Transgenic Mi...

por Hoffmann, Torsten, Rahfeld, Jens-Ulrich, Schenk, Mathias, Ponath, Falk, Makioka, Koki, Hutter-Paier, Birgit, Lues, Inge, Lemere, Cynthia A., Schilling, Stephan
Publicado 2021

Distinct glutaminyl cyclase expression in Edinger–Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Aβ pathology in Alzheimer’s disease

por Morawski, Markus, Hartlage-Rübsamen, Maike, Jäger, Carsten, Waniek, Alexander, Schilling, Stephan, Schwab, Claudia, McGeer, Patrick L., Arendt, Thomas, Demuth, Hans-Ulrich, Roßner, Steffen
Publicado 2010

Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Aβ deposits in hippocampus via distinct cellular mechanisms

por Hartlage-Rübsamen, Maike, Morawski, Markus, Waniek, Alexander, Jäger, Carsten, Zeitschel, Ulrike, Koch, Birgit, Cynis, Holger, Schilling, Stephan, Schliebs, Reinhard, Demuth, Hans-Ulrich, Roßner, Steffen
Publicado 2011

Evidence for Enhanced Efficacy of Passive Immunotherapy against Beta-Amyloid in CD33-Negative 5xFAD Mice

por Gnoth, Kathrin, Geissler, Stefanie, Feldhaus, Julia, Taudte, Nadine, Ilse, Victoria, Zürner, Sebastian, Greiser, Sebastian, Braumann, Ulf-Dietrich, Rahfeld, Jens-Ulrich, Cynis, Holger, Schilling, Stephan
Publicado 2022

Glutaminyl cyclase-mediated toxicity of pyroglutamate-beta amyloid induces striatal neurodegeneration

por Becker, Andreas, Kohlmann, Stephanie, Alexandru, Anca, Jagla, Wolfgang, Canneva, Fabio, Bäuscher, Christoph, Cynis, Holger, Sedlmeier, Reinhard, Graubner, Sigrid, Schilling, Stephan, Demuth, Hans-Ulrich, von Hörsten, Stephan
Publicado 2013

Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer’s disease

por Hartlage-Rübsamen, Maike, Waniek, Alexander, Meißner, Juliane, Morawski, Markus, Schilling, Stephan, Jäger, Carsten, Kleinschmidt, Martin, Cynis, Holger, Kehlen, Astrid, Arendt, Thomas, Demuth, Hans-Ulrich, Roßner, Steffen
Publicado 2015

Helical ultrastructure of the metalloprotease meprin α in complex with a small molecule inhibitor

por Bayly-Jones, Charles, Lupton, Christopher J., Fritz, Claudia, Venugopal, Hariprasad, Ramsbeck, Daniel, Wermann, Michael, Jäger, Christian, de Marco, Alex, Schilling, Stephan, Schlenzig, Dagmar, Whisstock, James C.
Publicado 2022

Mammalian-like type II glutaminyl cyclases in Porphyromonas gingivalis and other oral pathogenic bacteria as targets for treatment of periodontitis

por Taudte, Nadine, Linnert, Miriam, Rahfeld, Jens-Ulrich, Piechotta, Anke, Ramsbeck, Daniel, Buchholz, Mirko, Kolenko, Petr, Parthier, Christoph, Houston, John A., Veillard, Florian, Eick, Sigrun, Potempa, Jan, Schilling, Stephan, Demuth, Hans-Ulrich, Stubbs, Milton T.
Publicado 2021

Amyloid-Beta Peptides Trigger Aggregation of Alpha-Synuclein In Vitro

por Köppen, Janett, Schulze, Anja, Machner, Lisa, Wermann, Michael, Eichentopf, Rico, Guthardt, Max, Hähnel, Angelika, Klehm, Jessica, Kriegeskorte, Marie-Christin, Hartlage-Rübsamen, Maike, Morawski, Markus, von Hörsten, Stephan, Demuth, Hans-Ulrich, Roßner, Steffen, Schilling, Stephan
Publicado 2020

Infection control in the management of highly pathogenic infectious diseases: consensus of the European Network of Infectious Disease

por Brouqui, Philippe, Puro, Vincenzo, Fusco, Francesco M, Bannister, Barbara, Schilling, Stephan, Follin, Per, Gottschalk, René, Hemmer, Robert, Maltezou, Helena C, Ott, Kristi, Peleman, Renaat, Perronne, Christian, Sheehan, Gerard, Siikamäki, Heli, Skinhoj, Peter, Ippolito, Giuseppe
Publicado 2009

Targeting isoaspartate-modified Aβ rescues behavioral deficits in transgenic mice with Alzheimer’s disease-like pathology

por Gnoth, Kathrin, Piechotta, Anke, Kleinschmidt, Martin, Konrath, Sandra, Schenk, Mathias, Taudte, Nadine, Ramsbeck, Daniel, Rieckmann, Vera, Geissler, Stefanie, Eichentopf, Rico, Barendrecht, Susan, Hartlage-Rübsamen, Maike, Demuth, Hans-Ulrich, Roßner, Steffen, Cynis, Holger, Rahfeld, Jens-Ulrich, Schilling, Stephan
Publicado 2020