The inhibitory and inducing effects of ritonavir on hepatic and intestinal CYP3A and other drug-handling proteins

por Loos, Nancy H.C., Beijnen, Jos H., Schinkel, Alfred H.
Publicado 2023

The Mechanism-Based Inactivation of CYP3A4 by Ritonavir: What Mechanism?

por Loos, Nancy H. C., Beijnen, Jos H., Schinkel, Alfred H.
Publicado 2022

P-gp and taxanes

por Hendrikx, Jeroen J.M.A., Beijnen, Jos H., Schinkel, Alfred H.
Publicado 2014

ABCB1 and ABCG2 Control Brain Accumulation and Intestinal Disposition of the Novel ROS1/TRK/ALK Inhibitor Repotrectinib, While OATP1A/1B, ABCG2, and CYP3A Limit Its Oral Availabili...

por Li, Wenlong, Sparidans, Rolf W., Lebre, Maria C., Beijnen, Jos H., Schinkel, Alfred H.
Publicado 2021

Bioanalytical assay for the quantification of the tyrosine kinase inhibitor EAI045 and its major metabolite PIA in mouse plasma and tissue homogenates using liquid chromatography–t...

por Susam, M. Merve, Wang, Jing, Schinkel, Alfred H., Beijnen, Jos H., Sparidans, Rolf W.
Publicado 2022

Development and validation of a bioanalytical method for the quantification of the CDK4/6 inhibitors abemaciclib, palbociclib, and ribociclib in human and mouse matrices using liqu...

por Martínez-Chávez, Alejandra, Rosing, Hilde, Hillebrand, Michel, Tibben, Matthijs, Schinkel, Alfred H., Beijnen, Jos H.
Publicado 2019

Cytochrome P450 3A4, 3A5, and 2C8 expression in breast, prostate, lung, endometrial, and ovarian tumors: relevance for resistance to taxanes

por van Eijk, Maarten, Boosman, René J., Schinkel, Alfred H., Huitema, Alwin D. R., Beijnen, Jos H.
Publicado 2019

P-Glycoprotein (ABCB1/MDR1) and BCRP (ABCG2) Limit Brain Accumulation and Cytochrome P450-3A (CYP3A) Restricts Oral Exposure of the RET Inhibitor Selpercatinib (RETEVMO)

por Wang, Yaogeng, Sparidans, Rolf W., Potters, Sander, Şentürk, Rahime, Lebre, Maria C., Beijnen, Jos H., Schinkel, Alfred H.
Publicado 2021

Targeted disruption of organic cation transporter 3 (Oct3) ameliorates ischemic brain damage through modulating histamine and regulatory T cells

por Zhu, Pengxiang, Hata, Ryuji, Ogasawara, Masahito, Cao, Fang, Kameda, Kenji, Yamauchi, Kohei, Schinkel, Alfred H, Maeyama, Kazutaka, Sakanaka, Masahiro
Publicado 2012

P-Glycoprotein (MDR1/ABCB1) Restricts Brain Accumulation of the Novel EGFR Inhibitor EAI045 and Oral Elacridar Coadministration Enhances Its Brain Accumulation and Oral Exposure

por Wang, Jing, Susam, M. Merve, Gan, Changpei, Sparidans, Rolf W., Lebre, Maria C., Beijnen, Jos H., Schinkel, Alfred H.
Publicado 2022

Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse

por Kummer, Wolfgang, Wiegand, Silke, Akinci, Sibel, Wessler, Ignatz, Schinkel, Alfred H, Wess, Jürgen, Koepsell, Hermann, Haberberger, Rainer V, Lips, Katrin S
Publicado 2006

Predictiveness of the Human-CYP3A4-Transgenic Mouse Model (Cyp3aXAV) for Human Drug Exposure of CYP3A4-Metabolized Drugs

por Damoiseaux, David, Li, Wenlong, Martínez-Chávez, Alejandra, Beijnen, Jos H., Schinkel, Alfred H., Huitema, Alwin D. R., Dorlo, Thomas P. C.
Publicado 2022

Organic cation transporter 3 modulates murine basophil functions by controlling intracellular histamine levels

por Schneider, Elke, Machavoine, François, Pléau, Jean-Marie, Bertron, Anne-France, Thurmond, Robin L., Ohtsu, Hiroshi, Watanabe, Takehiko, Schinkel, Alfred H., Dy, Michel
Publicado 2005

Drug Transporters ABCB1 (P-gp) and OATP, but not Drug-Metabolizing Enzyme CYP3A4, Affect the Pharmacokinetics of the Psychoactive Alkaloid Ibogaine and its Metabolites

por F. Martins, Margarida L., Heydari, Paniz, Li, Wenlong, Martínez-Chávez, Alejandra, Venekamp, Nikkie, Lebre, Maria C., Lucas, Luc, Beijnen, Jos H., Schinkel, Alfred H.
Publicado 2022

Extrahepatic metabolism of ibrutinib

por Rood, Johannes J. M., Jamalpoor, Amer, van Hoppe, Stephanie, van Haren, Matthijs J., Wasmann, Roeland E., Janssen, Manoe J., Schinkel, Alfred H., Masereeuw, Rosalinde, Beijnen, Jos H., Sparidans, Rolf W.
Publicado 2020

Inhibition of Hepatic Bile Acid Uptake by Myrcludex B Promotes Glucagon-Like Peptide-1 Release and Reduces Obesity

por Donkers, Joanne M., Roscam Abbing, Reinout L.P., van Weeghel, Michel, Levels, Johannes H.M., Boelen, Anita, Schinkel, Alfred H., Oude Elferink, Ronald P.J., van de Graaf, Stan F.J.
Publicado 2020

No relation between docetaxel administration route and high‐grade diarrhea incidence

por Hendrikx, Jeroen J. M. A., Stuurman, Frederik E., Song, Ji‐Ying, de Weger, Vincent A., Lagas, Jurjen S., Rosing, Hilde, Beijnen, Jos H., Schinkel, Alfred H., Schellens, Jan H. M., Marchetti, Serena
Publicado 2020

Evidence of promiscuous endothelial binding by Plasmodium falciparum‐infected erythrocytes

por Esser, Claudia, Bachmann, Anna, Kuhn, Daniela, Schuldt, Kathrin, Förster, Birgit, Thiel, Meike, May, Jürgen, Koch‐Nolte, Friedrich, Yáñez‐Mó, María, Sánchez‐Madrid, Francisco, Schinkel, Alfred H., Jalkanen, Sirpa, Craig, Alister G., Bruchhaus, Iris, Horstmann, Rolf D.
Publicado 2014

P-Glycoprotein Acts as an Immunomodulator during Neuroinflammation

por Kooij, Gijs, Backer, Ronald, Koning, Jasper J., Reijerkerk, Arie, van Horssen, Jack, van der Pol, Susanne M. A., Drexhage, Joost, Schinkel, Alfred, Dijkstra, Christine D., den Haan, Joke M. M., Geijtenbeek, Teunis B. H., de Vries, Helga E.
Publicado 2009

Carboxylesterase 1 family knockout alters drug disposition and lipid metabolism

por Gan, Changpei, Wang, Jing, Martínez-Chávez, Alejandra, Hillebrand, Michel, de Vries, Niels, Beukers, Joke, Wagenaar, Els, Wang, Yaogeng, Lebre, Maria C., Rosing, Hilde, Klarenbeek, Sjoerd, Ali, Rahmen Bin, Pritchard, Colin, Huijbers, Ivo, Beijnen, Jos H., Schinkel, Alfred H.
Publicado 2023