Structure of the N-Terminal Gyrase B Fragment in Complex with ADP⋅P(i) Reveals Rigid-Body Motion Induced by ATP Hydrolysis

por Stanger, Frédéric V., Dehio, Christoph, Schirmer, Tilman
Publicado 2014

Activation mechanism of a small prototypic Rec-GGDEF diguanylate cyclase

por Teixeira, Raphael D., Holzschuh, Fabian, Schirmer, Tilman
Publicado 2021

Conserved Inhibitory Mechanism and Competent ATP Binding Mode for Adenylyltransferases with Fic Fold

por Goepfert, Arnaud, Stanger, Frédéric V., Dehio, Christoph, Schirmer, Tilman
Publicado 2013

Crystal Structure of the Escherichia coli Fic Toxin-Like Protein in Complex with Its Cognate Antitoxin

por Stanger, Frédéric V., Harms, Alexander, Dehio, Christoph, Schirmer, Tilman
Publicado 2016

Intercepting second-messenger signaling by rationally designed peptides sequestering c-di-GMP

por Hee, Chee-Seng, Habazettl, Judith, Schmutz, Christoph, Schirmer, Tilman, Jenal, Urs, Grzesiek, Stephan
Publicado 2020

Mutant structure of metabolic switch protein in complex with monomeric c-di-GMP reveals a potential mechanism of protein-mediated ligand dimerization

por Dubey, Badri Nath, Shyp, Viktoriya, Fucile, Geoffrey, Sondermann, Holger, Jenal, Urs, Schirmer, Tilman
Publicado 2023

Structural features discriminating hybrid histidine kinase Rec domains from response regulator homologs

por Brüderlin, Mitchell, Böhm, Raphael, Fadel, Firas, Hiller, Sebastian, Schirmer, Tilman, Dubey, Badri N.
Publicado 2023

Structural basis for selective AMPylation of Rac-subfamily GTPases by Bartonella effector protein 1 (Bep1)

por Dietz, Nikolaus, Huber, Markus, Sorg, Isabel, Goepfert, Arnaud, Harms, Alexander, Schirmer, Tilman, Dehio, Christoph
Publicado 2021

Cyclic di-GMP mediates a histidine kinase/phosphatase switch by noncovalent domain cross-linking

por Dubey, Badri N., Lori, Christian, Ozaki, Shogo, Fucile, Geoffrey, Plaza-Menacho, Ivan, Jenal, Urs, Schirmer, Tilman
Publicado 2016

Precise timing of transcription by c-di-GMP coordinates cell cycle and morphogenesis in Caulobacter

por Kaczmarczyk, Andreas, Hempel, Antje M., von Arx, Christoph, Böhm, Raphael, Dubey, Badri N., Nesper, Jutta, Schirmer, Tilman, Hiller, Sebastian, Jenal, Urs
Publicado 2020

Cyclic di-GMP differentially tunes a bacterial flagellar motor through a novel class of CheY-like regulators

por Nesper, Jutta, Hug, Isabelle, Kato, Setsu, Hee, Chee-Seng, Habazettl, Judith Maria, Manfredi, Pablo, Grzesiek, Stephan, Schirmer, Tilman, Emonet, Thierry, Jenal, Urs
Publicado 2017

Hybrid histidine kinase activation by cyclic di-GMP–mediated domain liberation

por Dubey, Badri N., Agustoni, Elia, Böhm, Raphael, Kaczmarczyk, Andreas, Mangia, Francesca, von Arx, Christoph, Jenal, Urs, Hiller, Sebastian, Plaza-Menacho, Iván, Schirmer, Tilman
Publicado 2020

A Bacterial Inflammation Sensor Regulates c-di-GMP Signaling, Adhesion, and Biofilm Formation

por Perkins, Arden, Tudorica, Dan A., Teixeira, Raphael D., Schirmer, Tilman, Zumwalt, Lindsay, Ogba, O. Maduka, Cassidy, C. Keith, Stansfeld, Phillip J., Guillemin, Karen
Publicado 2021

Evolutionary Diversification of Host-Targeted Bartonella Effectors Proteins Derived from a Conserved FicTA Toxin-Antitoxin Module

por Schirmer, Tilman, de Beer, Tjaart A. P., Tamegger, Stefanie, Harms, Alexander, Dietz, Nikolaus, Dranow, David M., Edwards, Thomas E., Myler, Peter J., Phan, Isabelle, Dehio, Christoph
Publicado 2021