Extracellular vesicles improve GABAergic transmission in Huntington's disease iPSC-derived neurons

por Beatriz, Margarida, Rodrigues, Ricardo J., Vilaça, Rita, Egas, Conceição, Pinheiro, Paulo S., Daley, George Q., Schlaeger, Thorsten M., Raimundo, Nuno, Rego, A. Cristina, Lopes, Carla
Publicado 2023

Mitochondrial and Redox Modifications in Huntington Disease Induced Pluripotent Stem Cells Rescued by CRISPR/Cas9 CAGs Targeting

por Lopes, Carla, Tang, Yang, Anjo, Sandra I., Manadas, Bruno, Onofre, Isabel, de Almeida, Luís P., Daley, George Q., Schlaeger, Thorsten M., Rego, Ana Cristina Carvalho
Publicado 2020

Synthetic genetic circuits to uncover the OCT4 trajectories of successful reprogramming of human fibroblasts

por Ilia, Katherine, Shakiba, Nika, Bingham, Trevor, Jones, Ross D., Kaminski, Michael M., Aravera, Eliezer, Bruno, Simone, Palacios, Sebastian, Weiss, Ron, Collins, James J., Del Vecchio, Domitilla, Schlaeger, Thorsten M.
Publicado 2023

Synthetic genetic circuits to uncover and enforce the OCT4 trajectories of successful reprogramming of human fibroblasts

por Ilia, Katherine, Shakiba, Nika, Bingham, Trevor, Jones, Ross D., Kaminski, Michael M., Aravera, Eliezer, Bruno, Simone, Palacios, Sebastian, Weiss, Ron, Collins, James J., Del Vecchio, Domitilla, Schlaeger, Thorsten M.
Publicado 2023

A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development

por Ciarlo, Christie, Kaufman, Charles K, Kinikoglu, Beste, Michael, Jonathan, Yang, Song, D′Amato, Christopher, Blokzijl-Franke, Sasja, den Hertog, Jeroen, Schlaeger, Thorsten M, Zhou, Yi, Liao, Eric, Zon, Leonard I
Publicado 2017

De Novo Generation of Pulmonary Ionocytes from Normal and Cystic Fibrosis Human Induced Pluripotent Stem Cells

por Wang, Ruobing, Simone-Roach, Chantelle, Lindstrom-Vautrin, Jonathan, Wang, Feiya, Rollins, Stuart, Bawa, Pushpinder Singh, Lu, Junjie, Tang, Yang, Beermann, Mary Lou, Schlaeger, Thorsten, Mahoney, John, Rowe, Steven M., Hawkins, Finn J., Kotton, Darrell N.
Publicado 2023

Flow-induced protein kinase A–CREB pathway acts via BMP signaling to promote HSC emergence

por Kim, Peter Geon, Nakano, Haruko, Das, Partha P., Chen, Michael J., Rowe, R. Grant, Chou, Stephanie S., Ross, Samantha J., Sakamoto, Kathleen M., Zon, Leonard I., Schlaeger, Thorsten M., Orkin, Stuart H., Nakano, Atsushi, Daley, George Q.
Publicado 2015

Developmental Vitamin D Availability Impacts Hematopoietic Stem Cell Production

por Cortes, Mauricio, Chen, Michael J., Stachura, David L., Liu, Sarah Y., Kwan, Wanda, Wright, Francis, Vo, Linda T., Theodore, Lindsay N., Esain, Virginie, Frost, Isaura M., Schlaeger, Thorsten M., Goessling, Wolfram, Daley, George Q., North, Trista E.
Publicado 2016

Epoxyeicosatrienoic Acids Enhance Embryonic Haematopoiesis and Adult Marrow Engraftment

por Li, Pulin, Lahvic, Jamie L., Binder, Vera, Pugach, Emily K., Riley, Elizabeth B., Tamplin, Owen J., Panigrahy, Dipak, Bowman, Teresa V., Barrett, Francesca G., Heffner, Garrett C., McKinney-Freeman, Shannon, Schlaeger, Thorsten M., Daley, George Q., Zeldin, Darryl C., Zon, Leonard I.
Publicado 2015

Adenosine signaling promotes hematopoietic stem and progenitor cell emergence

por Jing, Lili, Tamplin, Owen J., Chen, Michael J., Deng, Qing, Patterson, Shenia, Kim, Peter G., Durand, Ellen M., McNeil, Ashley, Green, Julie M., Matsuura, Shinobu, Ablain, Julien, Brandt, Margot K., Schlaeger, Thorsten M., Huttenlocher, Anna, Daley, George Q., Ravid, Katya, Zon, Leonard I.
Publicado 2015

Applying Deep Neural Network Analysis to High-Content Image-Based Assays

por Yang, Samuel J., Lipnick, Scott L., Makhortova, Nina R., Venugopalan, Subhashini, Fan, Minjie, Armstrong, Zan, Schlaeger, Thorsten M., Deng, Liyong, Chung, Wendy K., O’Callaghan, Liadan, Geraschenko, Anton, Whye, Dosh, Berndl, Marc, Hazard, Jon, Williams, Brian, Narayanaswamy, Arunachalam, Ando, D. Michael, Nelson, Philip, Rubin, Lee L.
Publicado 2019

Reticular dysgenesis–associated AK2 protects hematopoietic stem and progenitor cell development from oxidative stress

por Rissone, Alberto, Weinacht, Katja Gabriele, la Marca, Giancarlo, Bishop, Kevin, Giocaliere, Elisa, Jagadeesh, Jayashree, Felgentreff, Kerstin, Dobbs, Kerry, Al-Herz, Waleed, Jones, Marypat, Chandrasekharappa, Settara, Kirby, Martha, Wincovitch, Stephen, Simon, Karen Lyn, Itan, Yuval, DeVine, Alex, Schlaeger, Thorsten, Schambach, Axel, Sood, Raman, Notarangelo, Luigi D., Candotti, Fabio
Publicado 2015

Transcriptome Dynamics of Hematopoietic Stem Cell Formation Revealed Using a Combinatorial Runx1 and Ly6a Reporter System

por Chen, Michael J., Lummertz da Rocha, Edroaldo, Cahan, Patrick, Kubaczka, Caroline, Hunter, Phoebe, Sousa, Patricia, Mullin, Nathaniel K., Fujiwara, Yuko, Nguyen, Minh, Tan, Yuqi, Landry, Samuel, Han, Areum, Yang, Song, Lu, Yi-Fen, Jha, Deepak Kumar, Vo, Linda T., Zhou, Yi, North, Trista E., Zon, Leonard I., Daley, George Q., Schlaeger, Thorsten M.
Publicado 2020

Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells

por Lafaille, Fabien G, Pessach, Itai M., Zhang, Shen-Ying, Ciancanelli, Michael J., Herman, Melina, Abhyankar, Avinash, Ying, Shui-Wang, Keros, Sotirios, Goldstein, Peter A., Mostoslavsky, Gustavo, Ordovas-Montanes, Jose, Jouanguy, Emmanuelle, Plancoulaine, Sabine, Tu, Edmund, Elkabetz, Yechiel, Al-Muhsen, Saleh, Tardieu, Marc, Schlaeger, Thorsten M., Daley, George Q., Abel, Laurent, Casanova, Jean-Laurent, Studer, Lorenz, Notarangelo, Luigi D.
Publicado 2012

Morphological and Molecular Defects in Human Three-Dimensional Retinal Organoid Model of X-Linked Juvenile Retinoschisis

por Huang, Kang-Chieh, Wang, Mong-Lien, Chen, Shih-Jen, Kuo, Jean-Cheng, Wang, Won-Jing, Nhi Nguyen, Phan Nguyen, Wahlin, Karl J., Lu, Jyh-Feng, Tran, Audrey A., Shi, Michael, Chien, Yueh, Yarmishyn, Aliaksandr A., Tsai, Ping-Hsing, Yang, Tien-Chun, Jane, Wann-Neng, Chang, Chia-Ching, Peng, Chi-Hsien, Schlaeger, Thorsten M., Chiou, Shih-Hwa
Publicado 2019

The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles

por Coulter, Michael E., Dorobantu, Cristina M., Lodewijk, Gerrald A., Delalande, François, Cianferani, Sarah, Ganesh, Vijay S., Smith, Richard S., Lim, Elaine T., Xu, C. Shan, Pang, Song, Wong, Eric T., Lidov, Hart G.W., Calicchio, Monica L., Yang, Edward, Gonzalez, Dilenny M., Schlaeger, Thorsten M., Mochida, Ganeshwaran H., Hess, Harald, Allen Lee, Wei-Chung, Lehtinen, Maria K., Kirchhausen, Tomas, Haussler, David, Jacobs, Frank M.J., Gaudin, Raphael, Walsh, Christopher A.
Publicado 2018

Genome sequencing unveils a regulatory landscape of platelet reactivity

por Keramati, Ali R., Chen, Ming-Huei, Rodriguez, Benjamin A. T., Yanek, Lisa R., Bhan, Arunoday, Gaynor, Brady J., Ryan, Kathleen, Brody, Jennifer A., Zhong, Xue, Wei, Qiang, Kammers, Kai, Kanchan, Kanika, Iyer, Kruthika, Kowalski, Madeline H., Pitsillides, Achilleas N., Cupples, L. Adrienne, Li, Bingshan, Schlaeger, Thorsten M., Shuldiner, Alan R., O’Connell, Jeffrey R., Ruczinski, Ingo, Mitchell, Braxton D., Faraday, Nauder, Taub, Margaret A., Becker, Lewis C., Lewis, Joshua P., Mathias, Rasika A., Johnson, Andrew D.
Publicado 2021

A recurrent, homozygous EMC10 frameshift variant is associated with a syndrome of developmental delay with variable seizures and dysmorphic features

por Shao, Diane D., Straussberg, Rachel, Ahmed, Hind, Khan, Amjad, Tian, Songhai, Hill, R. Sean, Smith, Richard S., Majmundar, Amar J., Ameziane, Najim, Neil, Jennifer E., Yang, Edward, Al Tenaiji, Amal, Jamuar, Saumya S., Schlaeger, Thorsten M., Al-Saffar, Muna, Hovel, Iris, Al-Shamsi, Aisha, Basel-Salmon, Lina, Amir, Achiya Z., Rento, Lariza M., Lim, Jiin Ying, Ganesan, Indra, Shril, Shirlee, Evrony, Gilad, Barkovich, A. James, Bauer, Peter, Hildebrandt, Friedhelm, Dong, Min, Borck, Guntram, Beetz, Christian, Al-Gazali, Lihadh, Eyaid, Wafaa, Walsh, Christopher A.
Publicado 2021