Genome-wide CRISPR synthetic lethality screen identifies a role for the ADP-ribosyltransferase PARP14 in DNA replication dynamics controlled by ATR

por Dhoonmoon, Ashna, Schleicher, Emily M, Clements, Kristen E, Nicolae, Claudia M, Moldovan, George-Lucian
Publicado 2020

PARP10 promotes cellular proliferation and tumorigenesis by alleviating replication stress

por Schleicher, Emily M, Galvan, Adri M, Imamura-Kawasawa, Yuka, Moldovan, George-Lucian, Nicolae, Claudia M
Publicado 2018

Lagging strand gap suppression connects BRCA-mediated fork protection to nucleosome assembly through PCNA-dependent CAF-1 recycling

por Thakar, Tanay, Dhoonmoon, Ashna, Straka, Joshua, Schleicher, Emily M., Nicolae, Claudia M., Moldovan, George-Lucian
Publicado 2022

The TIP60-ATM axis regulates replication fork stability in BRCA-deficient cells

por Schleicher, Emily M., Dhoonmoon, Ashna, Jackson, Lindsey M., Khatib, Jude B., Nicolae, Claudia M., Moldovan, George-Lucian
Publicado 2022

Complementary CRISPR genome-wide genetic screens in PARP10-knockout and overexpressing cells identify synthetic interactions for PARP10-mediated cellular survival

por Khatib, Jude B., Schleicher, Emily M., Jackson, Lindsey M., Dhoonmoon, Ashna, Moldovan, George-Lucian, Nicolae, Claudia M.
Publicado 2022

Loss of MED12 activates the TGFβ pathway to promote chemoresistance and replication fork stability in BRCA-deficient cells

por Jackson, Lindsey M, Dhoonmoon, Ashna, Hale, Anastasia, Dennis, Kady A, Schleicher, Emily M, Nicolae, Claudia M, Moldovan, George-Lucian
Publicado 2021

Dual genome-wide CRISPR knockout and CRISPR activation screens identify mechanisms that regulate the resistance to multiple ATR inhibitors

por Schleicher, Emily M., Dhoonmoon, Ashna, Jackson, Lindsey M., Clements, Kristen E., Stump, Coryn L., Nicolae, Claudia M., Moldovan, George-Lucian
Publicado 2020

Interactions between the WEE-1.3 kinase and the PAM-1 aminopeptidase in oocyte maturation and the early C. elegans embryo

por Benton, Dorothy, Jaeger, Eva C, Kilner, Arielle, Kimble, Ashley, Lowry, Josh, Schleicher, Emily M, Power, Kaiden M, Uibel, Danielle, Eisele, Caprice, Bowerman, Bruce, Lyczak, Rebecca
Publicado 2021

Tristetraprolin targets Nos2 expression in the colonic epithelium

por Eshelman, Melanie A., Matthews, Stephen M., Schleicher, Emily M., Fleeman, Rebecca M., Kawasawa, Yuka Imamura, Stumpo, Deborah J., Blackshear, Perry J., Koltun, Walter A., Ishmael, Faoud T., Yochum, Gregory S.
Publicado 2019

Identification of regulators of poly-ADP-ribose polymerase inhibitor response through complementary CRISPR knockout and activation screens

por Clements, Kristen E., Schleicher, Emily M., Thakar, Tanay, Hale, Anastasia, Dhoonmoon, Ashna, Tolman, Nathanial J., Sharma, Anchal, Liang, Xinwen, Imamura Kawasawa, Yuka, Nicolae, Claudia M., Wang, Hong-Gang, De, Subhajyoti, Moldovan, George-Lucian
Publicado 2020