Development of a Whole-Body Physiologically Based Pharmacokinetic Approach to Assess the Pharmacokinetics of Drugs in Elderly Individuals

por Schlender, Jan-Frederik, Meyer, Michaela, Thelen, Kirstin, Krauss, Markus, Willmann, Stefan, Eissing, Thomas, Jaehde, Ulrich
Publicado 2016

A Physiologically-Based Pharmacokinetic Model to Describe Ciprofloxacin Pharmacokinetics Over the Entire Span of Life

por Schlender, Jan-Frederik, Teutonico, Donato, Coboeken, Katrin, Schnizler, Katrin, Eissing, Thomas, Willmann, Stefan, Jaehde, Ulrich, Stass, Heino
Publicado 2018

Physiologically Based Pharmacokinetic Modeling of Monoclonal Antibodies in Pediatric Populations Using PK-Sim

por Basu, Sumit, Lien, Yi Ting (Kayla), Vozmediano, Valvanera, Schlender, Jan-Frederik, Eissing, Thomas, Schmidt, Stephan, Niederalt, Christoph
Publicado 2020

Predictive Performance of Physiology‐Based Pharmacokinetic Dose Estimates for Pediatric Trials: Evaluation With 10 Bayer Small‐Molecule Compounds in Children

por Ince, Ibrahim, Dallmann, André, Frechen, Sebastian, Coboeken, Katrin, Niederalt, Christoph, Wendl, Thomas, Block, Michael, Meyer, Michaela, Eissing, Thomas, Burghaus, Rolf, Lippert, Jörg, Willmann, Stefan, Schlender, Jan‐Frederik
Publicado 2021

Data‐driven personalization of a physiologically based pharmacokinetic model for caffeine: A systematic assessment

por Fendt, Rebekka, Hofmann, Ute, Schneider, Annika R. P., Schaeffeler, Elke, Burghaus, Rolf, Yilmaz, Ali, Blank, Lars Mathias, Kerb, Reinhold, Lippert, Jörg, Schlender, Jan‐Frederik, Schwab, Matthias, Kuepfer, Lars
Publicado 2021

Increased sinusoidal export of drug glucuronides is a compensative mechanism in liver cirrhosis of mice

por Fendt, Rebekka, Ghallab, Ahmed, Myllys, Maiju, Hofmann, Ute, Hassan, Reham, Hobloss, Zaynab, González, Daniela, Brackhagen, Lisa, Marchan, Rosemarie, Edlund, Karolina, Seddek, Abdel-Latif, Abdelmageed, Noha, Blank, Lars M., Schlender, Jan-Frederik, Holland, Christian H., Hengstler, Jan G., Kuepfer, Lars
Publicado 2023