Activation of immune evasion machinery is a part of the process of malignant transformation of human cells

por Abooali, Maryam, Yasinska, Inna M., Schlichtner, Stephanie, Ruggiero, Sabrina, Berger, Steffen M., Cholewa, Dietmar, Milošević, Milan, Bartenstein, Andreas, Fasler-Kan, Elizaveta, Sumbayev, Vadim V.
Publicado 2023

Macrophage Differentiation and Polarization Regulate the Release of the Immune Checkpoint Protein V-Domain Ig Suppressor of T Cell Activation

por Noubissi Nzeteu, Gaetan Aime, Schlichtner, Stephanie, David, Sulamith, Ruppenstein, Aylin, Fasler-Kan, Elizaveta, Raap, Ulrike, Sumbayev, Vadim V., Gibbs, Bernhard F., Meyer, N. Helge
Publicado 2022

T lymphocytes induce human cancer cells derived from solid malignant tumors to secrete galectin-9 which facilitates immunosuppression in cooperation with other immune checkpoint pr...

por Schlichtner, Stephanie, Yasinska, Inna M, Lall, Gurprit S, Berger, Steffen M, Ruggiero, Sabrina, Cholewa, Dietmar, Aliu, Nijas, Gibbs, Bernhard F, Fasler-Kan, Elizaveta, Sumbayev, Vadim V
Publicado 2023

Expression of the Immune Checkpoint Protein VISTA Is Differentially Regulated by the TGF-β1 – Smad3 Signaling Pathway in Rapidly Proliferating Human Cells and T Lymphocytes

por Schlichtner, Stephanie, Yasinska, Inna M., Ruggiero, Sabrina, Berger, Steffen M., Aliu, Nijas, Prunk, Mateja, Kos, Janko, Meyer, N. Helge, Gibbs, Bernhard F., Fasler-Kan, Elizaveta, Sumbayev, Vadim V.
Publicado 2022

L-Kynurenine participates in cancer immune evasion by downregulating hypoxic signaling in T lymphocytes

por Schlichtner, Stephanie, Yasinska, Inna M., Klenova, Elena, Abooali, Maryam, Lall, Gurprit S., Berger, Steffen M., Ruggiero, Sabrina, Cholewa, Dietmar, Milošević, Milan, Gibbs, Bernhard F., Fasler-Kan, Elizaveta, Sumbayev, Vadim V.
Publicado 2023

High Mobility Group Box 1 (HMGB1) Induces Toll-Like Receptor 4-Mediated Production of the Immunosuppressive Protein Galectin-9 in Human Cancer Cells

por Teo Hansen Selnø, Anette, Schlichtner, Stephanie, Yasinska, Inna M., Sakhnevych, Svetlana S., Fiedler, Walter, Wellbrock, Jasmin, Berger, Steffen M., Klenova, Elena, Gibbs, Bernhard F., Fasler-Kan, Elizaveta, Sumbayev, Vadim V.
Publicado 2021

Transforming growth factor beta type 1 (TGF-β) and hypoxia-inducible factor 1 (HIF-1) transcription complex as master regulators of the immunosuppressive protein galectin-9 express...

por Selnø, Anette Teo Hansen, Schlichtner, Stephanie, Yasinska, Inna M., Sakhnevych, Svetlana S., Fiedler, Walter, Wellbrock, Jasmin, Klenova, Elena, Pavlova, Ludmila, Gibbs, Bernhard F., Degen, Martin, Schnyder, Isabelle, Aliu, Nijas, Berger, Steffen M., Fasler-Kan, Elizaveta, Sumbayev, Vadim V.
Publicado 2020

Ligand-Receptor Interactions of Galectin-9 and VISTA Suppress Human T Lymphocyte Cytotoxic Activity

por Yasinska, Inna M., Meyer, N. Helge, Schlichtner, Stephanie, Hussain, Rohanah, Siligardi, Giuliano, Casely-Hayford, Maxwell, Fiedler, Walter, Wellbrock, Jasmin, Desmet, Cloe, Calzolai, Luigi, Varani, Luca, Berger, Steffen M., Raap, Ulrike, Gibbs, Bernhard F., Fasler-Kan, Elizaveta, Sumbayev, Vadim V.
Publicado 2020