Proteasome inhibition slightly improves cardiac function in mice with hypertrophic cardiomyopathy

por Schlossarek, Saskia, Singh, Sonia R., Geertz, Birgit, Schulz, Herbert, Reischmann, Silke, Hübner, Norbert, Carrier, Lucie
Publicado 2014

A Transgenic Mouse Model of Eccentric Left Ventricular Hypertrophy With Preserved Ejection Fraction Exhibits Alterations in the Autophagy-Lysosomal Pathway

por Wenzel, Kristin, Krämer, Elisabeth, Geertz, Birgit, Carrier, Lucie, Felix, Stephan B., Könemann, Stephanie, Schlossarek, Saskia
Publicado 2021

Myoarchitectural disarray of hypertrophic cardiomyopathy begins pre‐birth

por Garcia‐Canadilla, Patricia, Cook, Andrew C., Mohun, Timothy J., Oji, Onyedikachi, Schlossarek, Saskia, Carrier, Lucie, McKenna, William J., Moon, James C., Captur, Gabriella
Publicado 2019

Aldosterone Inhibits the Fetal Program and Increases Hypertrophy in the Heart of Hypertensive Mice

por Azibani, Feriel, Devaux, Yvan, Coutance, Guillaume, Schlossarek, Saskia, Polidano, Evelyne, Fazal, Loubina, Merval, Regine, Carrier, Lucie, Solal, Alain Cohen, Chatziantoniou, Christos, Launay, Jean-Marie, Samuel, Jane-Lise, Delcayre, Claude
Publicado 2012

Phosphomimetic cardiac myosin-binding protein C partially rescues a cardiomyopathy phenotype in murine engineered heart tissue

por Dutsch, Alexander, Wijnker, Paul J. M., Schlossarek, Saskia, Friedrich, Felix W., Krämer, Elisabeth, Braren, Ingke, Hirt, Marc N., Brenière-Letuffe, David, Rhoden, Alexandra, Mannhardt, Ingra, Eschenhagen, Thomas, Carrier, Lucie, Mearini, Giulia
Publicado 2019

Rescue of cardiomyopathy through U7snRNA-mediated exon skipping in Mybpc3-targeted knock-in mice

por Gedicke-Hornung, Christina, Behrens-Gawlik, Verena, Reischmann, Silke, Geertz, Birgit, Stimpel, Doreen, Weinberger, Florian, Schlossarek, Saskia, Précigout, Guillaume, Braren, Ingke, Eschenhagen, Thomas, Mearini, Giulia, Lorain, Stéphanie, Voit, Thomas, Dreyfus, Patrick A, Garcia, Luis, Carrier, Lucie
Publicado 2013

A high-throughput screening identifies ZNF418 as a novel regulator of the ubiquitin-proteasome system and autophagy-lysosomal pathway

por Singh, Sonia R, Meyer-Jens, Moritz, Alizoti, Erda, Bacon, W Clark, Davis, Gregory, Osinska, Hanna, Gulick, James, Reischmann-Düsener, Silke, Orthey, Ellen, McLendon, Patrick M, Molkentin, Jeffery D, Schlossarek, Saskia, Robbins, Jeffrey, Carrier, Lucie
Publicado 2020

Impact of AT2 Receptor Deficiency on Postnatal Cardiovascular Development

por Biermann, Daniel, Heilmann, Andreas, Didié, Michael, Schlossarek, Saskia, Wahab, Azadeh, Grimm, Michael, Römer, Maria, Reichenspurner, Hermann, Sultan, Karim R., Steenpass, Anna, Ergün, Süleyman, Donzelli, Sonia, Carrier, Lucie, Ehmke, Heimo, Zimmermann, Wolfram H., Hein, Lutz, Böger, Rainer H., Benndorf, Ralf A.
Publicado 2012

The embryological basis of subclinical hypertrophic cardiomyopathy

por Captur, Gabriella, Ho, Carolyn Y., Schlossarek, Saskia, Kerwin, Janet, Mirabel, Mariana, Wilson, Robert, Rosmini, Stefania, Obianyo, Chinwe, Reant, Patricia, Bassett, Paul, Cook, Andrew C., Lindsay, Susan, McKenna, William J., Mills, Kevin, Elliott, Perry M., Mohun, Timothy J., Carrier, Lucie, Moon, James C.
Publicado 2016

Proteomic and Functional Studies Reveal Detyrosinated Tubulin as Treatment Target in Sarcomere Mutation-Induced Hypertrophic Cardiomyopathy

por Schuldt, Maike, Pei, Jiayi, Harakalova, Magdalena, Dorsch, Larissa M., Schlossarek, Saskia, Mokry, Michal, Knol, Jaco C., Pham, Thang V., Schelfhorst, Tim, Piersma, Sander R., dos Remedios, Cris, Dalinghaus, Michiel, Michels, Michelle, Asselbergs, Folkert W., Moutin, Marie-Jo, Carrier, Lucie, Jimenez, Connie R., van der Velden, Jolanda, Kuster, Diederik W.D.
Publicado 2021

The homozygous K280N troponin T mutation alters cross-bridge kinetics and energetics in human HCM

por Piroddi, Nicoletta, Witjas-Paalberends, E. Rosalie, Ferrara, Claudia, Ferrantini, Cecilia, Vitale, Giulia, Scellini, Beatrice, Wijnker, Paul J.M., Sequiera, Vasco, Dooijes, Dennis, dos Remedios, Cristobal, Schlossarek, Saskia, Leung, Man Ching, Messer, Andrew, Ward, Douglas G., Biggeri, Annibale, Tesi, Chiara, Carrier, Lucie, Redwood, Charles S., Marston, Steven B., van der Velden, Jolanda, Poggesi, Corrado
Publicado 2019

ACTN2 Mutant Causes Proteopathy in Human iPSC-Derived Cardiomyocytes

por Zech, Antonia T. L., Prondzynski, Maksymilian, Singh, Sonia R., Pietsch, Niels, Orthey, Ellen, Alizoti, Erda, Busch, Josefine, Madsen, Alexandra, Behrens, Charlotta S., Meyer-Jens, Moritz, Mearini, Giulia, Lemoine, Marc D., Krämer, Elisabeth, Mosqueira, Diogo, Virdi, Sanamjeet, Indenbirken, Daniela, Depke, Maren, Salazar, Manuela Gesell, Völker, Uwe, Braren, Ingke, Pu, William T., Eschenhagen, Thomas, Hammer, Elke, Schlossarek, Saskia, Carrier, Lucie
Publicado 2022

Disease modeling of a mutation in α‐actinin 2 guides clinical therapy in hypertrophic cardiomyopathy

por Prondzynski, Maksymilian, Lemoine, Marc D, Zech, Antonia TL, Horváth, András, Di Mauro, Vittoria, Koivumäki, Jussi T, Kresin, Nico, Busch, Josefine, Krause, Tobias, Krämer, Elisabeth, Schlossarek, Saskia, Spohn, Michael, Friedrich, Felix W, Münch, Julia, Laufer, Sandra D, Redwood, Charles, Volk, Alexander E, Hansen, Arne, Mearini, Giulia, Catalucci, Daniele, Meyer, Christian, Christ, Torsten, Patten, Monica, Eschenhagen, Thomas, Carrier, Lucie
Publicado 2019