Binding of the Human 14-3-3 Isoforms to Distinct Sites in the Leucine-Rich Repeat Kinase 2

por Manschwetus, Jascha T., Wallbott, Maximilian, Fachinger, Alexandra, Obergruber, Claudia, Pautz, Sabine, Bertinetti, Daniela, Schmidt, Sven H., Herberg, Friedrich W.
Publicado 2020

Kinase Domain Is a Dynamic Hub for Driving LRRK2 Allostery

por Taylor, Susan S., Kaila-Sharma, Pallavi, Weng, Jui-Hung, Aoto, Phillip, Schmidt, Sven H., Knapp, Stefan, Mathea, Sebastian, Herberg, Friedrich W.
Publicado 2020

The dynamic switch mechanism that leads to activation of LRRK2 is embedded in the DFGψ motif in the kinase domain

por Schmidt, Sven H., Knape, Matthias J., Boassa, Daniela, Mumdey, Natascha, Kornev, Alexandr P., Ellisman, Mark H., Taylor, Susan S., Herberg, Friedrich W.
Publicado 2019

Molecular Basis for Ser/Thr Specificity in PKA Signaling

por Knape, Matthias J., Wallbott, Maximilian, Burghardt, Nicole C. G., Bertinetti, Daniela, Hornung, Jan, Schmidt, Sven H., Lorenz, Robin, Herberg, Friedrich W.
Publicado 2020

Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2

por Schmidt, Sven H., Weng, Jui-Hung, Aoto, Phillip C., Boassa, Daniela, Mathea, Sebastian, Silletti, Steve, Hu, Junru, Wallbott, Maximilian, Komives, Elizabeth A., Knapp, Stefan, Herberg, Friedrich W., Taylor, Susan S.
Publicado 2021

LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains

por Weng, Jui-Hung, Aoto, Phillip C., Lorenz, Robin, Wu, Jian, Schmidt, Sven H., Manschwetus, Jascha T., Kaila-Sharma, Pallavi, Silletti, Steve, Mathea, Sebastian, Chatterjee, Deep, Knapp, Stefan, Herberg, Friedrich W., Taylor, Susan S.
Publicado 2022

Nanobodies as allosteric modulators of Parkinson’s disease–associated LRRK2

por Singh, Ranjan K., Soliman, Ahmed, Guaitoli, Giambattista, Störmer, Eliza, von Zweydorf, Felix, Dal Maso, Thomas, Oun, Asmaa, Van Rillaer, Laura, Schmidt, Sven H., Chatterjee, Deep, David, Joshua A., Pardon, Els, Schwartz, Thomas U., Knapp, Stefan, Kennedy, Eileen J., Steyaert, Jan, Herberg, Friedrich W., Kortholt, Arjan, Gloeckner, Christian Johannes, Versées, Wim
Publicado 2022