Metabolic Response to XD14 Treatment in Human Breast Cancer Cell Line MCF-7

por Pan, Daqiang, Kather, Michel, Willmann, Lucas, Schlimpert, Manuel, Bauer, Christoph, Lagies, Simon, Schmidtkunz, Karin, Eisenhardt, Steffen U., Jung, Manfred, Günther, Stefan, Kammerer, Bernd
Publicado 2016

Preparation data of the bromodomains BRD3(1), BRD3(2), BRD4(1), and BRPF1B and crystallization of BRD4(1)-inhibitor complexes

por Hügle, Martin, Lucas, Xavier, Weitzel, Gerhard, Ostrovskyi, Dmytro, Breit, Bernhard, Gerhardt, Stefan, Schmidtkunz, Karin, Jung, Manfred, Schüle, Roland, Einsle, Oliver, Günther, Stefan, Wohlwend, Daniel
Publicado 2016

Sirtuin 1 Inhibiting Thiocyanates (S1th)—A New Class of Isotype Selective Inhibitors of NAD(+) Dependent Lysine Deacetylases

por Wössner, Nathalie, Alhalabi, Zayan, González, Jessica, Swyter, Sören, Gan, Jin, Schmidtkunz, Karin, Zhang, Lin, Vaquero, Alejandro, Ovaa, Huib, Einsle, Oliver, Sippl, Wolfgang, Jung, Manfred
Publicado 2020

A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing

por Simoben, Conrad V., Robaa, Dina, Chakrabarti, Alokta, Schmidtkunz, Karin, Marek, Martin, Lancelot, Julien, Kannan, Srinivasaraghavan, Melesina, Jelena, Shaik, Tajith B., Pierce, Raymond J., Romier, Christophe, Jung, Manfred, Sippl, Wolfgang
Publicado 2018

Identification of a small-molecule ligand of the epigenetic reader protein Spindlin1 via a versatile screening platform

por Wagner, Tobias, Greschik, Holger, Burgahn, Teresa, Schmidtkunz, Karin, Schott, Anne-Kathrin, McMillan, Joel, Baranauskienė, Lina, Xiong, Yan, Fedorov, Oleg, Jin, Jian, Oppermann, Udo, Matulis, Daumantas, Schüle, Roland, Jung, Manfred
Publicado 2016

Design, Synthesis and Biological Characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with Anti-Neuroblastoma Activity

por Darwish, Salma, Ghazy, Ehab, Heimburg, Tino, Herp, Daniel, Zeyen, Patrik, Salem-Altintas, Rabia, Ridinger, Johannes, Robaa, Dina, Schmidtkunz, Karin, Erdmann, Frank, Schmidt, Matthias, Romier, Christophe, Jung, Manfred, Oehme, Ina, Sippl, Wolfgang
Publicado 2022

Structural Basis for the Inhibition of Histone Deacetylase 8 (HDAC8), a Key Epigenetic Player in the Blood Fluke Schistosoma mansoni

por Marek, Martin, Kannan, Srinivasaraghavan, Hauser, Alexander-Thomas, Moraes Mourão, Marina, Caby, Stéphanie, Cura, Vincent, Stolfa, Diana A., Schmidtkunz, Karin, Lancelot, Julien, Andrade, Luiza, Renaud, Jean-Paul, Oliveira, Guilherme, Sippl, Wolfgang, Jung, Manfred, Cavarelli, Jean, Pierce, Raymond J., Romier, Christophe
Publicado 2013

Selective Sirt2 inhibition by ligand-induced rearrangement of the active site

por Rumpf, Tobias, Schiedel, Matthias, Karaman, Berin, Roessler, Claudia, North, Brian J., Lehotzky, Attila, Oláh, Judit, Ladwein, Kathrin I., Schmidtkunz, Karin, Gajer, Markus, Pannek, Martin, Steegborn, Clemens, Sinclair, David A., Gerhardt, Stefan, Ovádi, Judit, Schutkowski, Mike, Sippl, Wolfgang, Einsle, Oliver, Jung, Manfred
Publicado 2015

First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement

por Herp, Daniel, Ridinger, Johannes, Robaa, Dina, Shinsky, Stephen A., Schmidtkunz, Karin, Yesiloglu, Talha Z., Bayer, Theresa, Steimbach, Raphael R., Herbst‐Gervasoni, Corey J., Merz, Annika, Romier, Christophe, Sehr, Peter, Gunkel, Nikolas, Miller, Aubry K., Christianson, David W., Oehme, Ina, Sippl, Wolfgang, Jung, Manfred
Publicado 2022