Prediction of designer-recombinases for DNA editing with generative deep learning

por Schmitt, Lukas Theo, Paszkowski-Rogacz, Maciej, Jug, Florian, Buchholz, Frank
Publicado 2022

Prevention of episodic migraines with topiramate: results from a non-interventional study in a general practice setting

por Nelles, Gereon, Schmitt, Lukas, Humbert, Thomas, Becker, Veit, Sandow, Petra, Bornhoevd, Karin, Fritzsche, Dirk, Schäuble, Barbara
Publicado 2009

Discovery and characterization of novel Cre-type tyrosine site-specific recombinases for advanced genome engineering

por Jelicic, Milica, Schmitt, Lukas Theo, Paszkowski-Rogacz, Maciej, Walder, Angelika, Schubert, Nadja, Hoersten, Jenna, Sürün, Duran, Buchholz, Frank
Publicado 2023

A heterodimer of evolved designer-recombinases precisely excises a human genomic DNA locus

por Lansing, Felix, Paszkowski-Rogacz, Maciej, Schmitt, Lukas Theo, Schneider, Paul Martin, Rojo Romanos, Teresa, Sonntag, Jan, Buchholz, Frank
Publicado 2020

Circulating tumour cells in patients with lung cancer universally indicate poor prognosis

por Jin, Fukang, Zhu, Lei, Shao, Jingbo, Yakoub, Mina, Schmitt, Lukas, Reißfelder, Christoph, Loges, Sonja, Benner, Axel, Schölch, Sebastian
Publicado 2022

Quantification of evolved DNA-editing enzymes at scale with DEQSeq

por Schmitt, Lukas Theo, Schneider, Aksana, Posorski, Jonas, Lansing, Felix, Jelicic, Milica, Jain, Manavi, Sayed, Shady, Buchholz, Frank, Sürün, Duran
Publicado 2023

Scalable, Lightweight, Integrated and Quick-to-Assemble (SLIQ) Hyperdrives for Functional Circuit Dissection

por Liang, Li, Oline, Stefan N., Kirk, Justin C., Schmitt, Lukas Ian, Komorowski, Robert W., Remondes, Miguel, Halassa, Michael M.
Publicado 2017

DNA methylation–independent long-term epigenetic silencing with dCRISPR/Cas9 fusion proteins

por Ding, Li, Schmitt, Lukas Theo, Brux, Melanie, Sürün, Duran, Augsburg, Martina, Lansing, Felix, Mircetic, Jovan, Theis, Mirko, Buchholz, Frank
Publicado 2022

Pairing of single mutations yields obligate Cre-type site-specific recombinases

por Hoersten, Jenna, Ruiz-Gómez, Gloria, Lansing, Felix, Rojo-Romanos, Teresa, Schmitt, Lukas Theo, Sonntag, Jan, Pisabarro, M Teresa, Buchholz, Frank
Publicado 2021

Mechanical and Functional Improvement of β-TCP Scaffolds for Use in Bone Tissue Engineering

por Umrath, Felix, Schmitt, Lukas-Frank, Kliesch, Sophie-Maria, Schille, Christine, Geis-Gerstorfer, Jürgen, Gurewitsch, Elina, Bahrini, Kathleen, Peters, Fabian, Reinert, Siegmar, Alexander, Dorothea
Publicado 2023

Influence of Human Jaw Periosteal Cells Seeded β-Tricalcium Phosphate Scaffolds on Blood Coagulation

por Weber, Marbod, Umrath, Felix, Steinle, Heidrun, Schmitt, Lukas-Frank, Yu, Lin Tzu, Schlensak, Christian, Wendel, Hans-Peter, Reinert, Siegmar, Alexander, Dorothea, Avci-Adali, Meltem
Publicado 2021

Efficient Correction of Oncogenic KRAS and TP53 Mutations through CRISPR Base Editing

por Sayed, Shady, Sidorova, Olga A., Hennig, Alexander, Augsburg, Martina, Cortés Vesga, Catherine P., Abohawya, Moustafa, Schmitt, Lukas T., Sürün, Duran, Stange, Daniel E., Mircetic, Jovan, Buchholz, Frank
Publicado 2022

A large-scale resource for tissue-specific CRISPR mutagenesis in Drosophila

por Port, Fillip, Strein, Claudia, Stricker, Mona, Rauscher, Benedikt, Heigwer, Florian, Zhou, Jun, Beyersdörffer, Celine, Frei, Jana, Hess, Amy, Kern, Katharina, Lange, Laura, Langner, Nora, Malamud, Roberta, Pavlović, Bojana, Rädecke, Kristin, Schmitt, Lukas, Voos, Lukas, Valentini, Erica, Boutros, Michael
Publicado 2020

Correction of a Factor VIII genomic inversion with designer-recombinases

por Lansing, Felix, Mukhametzyanova, Liliya, Rojo-Romanos, Teresa, Iwasawa, Kentaro, Kimura, Masaki, Paszkowski-Rogacz, Maciej, Karpinski, Janet, Grass, Tobias, Sonntag, Jan, Schneider, Paul Martin, Günes, Ceren, Hoersten, Jenna, Schmitt, Lukas Theo, Rodriguez-Muela, Natalia, Knöfler, Ralf, Takebe, Takanori, Buchholz, Frank
Publicado 2022

Functional Therapeutic Target Validation Using Pediatric Zebrafish Xenograft Models

por Gatzweiler, Charlotte, Ridinger, Johannes, Herter, Sonja, Gerloff, Xenia F., ElHarouni, Dina, Berker, Yannick, Imle, Roland, Schmitt, Lukas, Kreth, Sina, Stainczyk, Sabine, Ayhan, Simay, Najafi, Sara, Krunic, Damir, Frese, Karen, Meder, Benjamin, Reuss, David, Fiesel, Petra, Schramm, Kathrin, Blattner-Johnson, Mirjam, Jones, David T. W., Banito, Ana, Westermann, Frank, Oppermann, Sina, Milde, Till, Peterziel, Heike, Witt, Olaf, Oehme, Ina
Publicado 2022