Prediction of designer-recombinases for DNA editing with generative deep learning

por Schmitt, Lukas Theo, Paszkowski-Rogacz, Maciej, Jug, Florian, Buchholz, Frank
Publicado 2022

Discovery and characterization of novel Cre-type tyrosine site-specific recombinases for advanced genome engineering

por Jelicic, Milica, Schmitt, Lukas Theo, Paszkowski-Rogacz, Maciej, Walder, Angelika, Schubert, Nadja, Hoersten, Jenna, Sürün, Duran, Buchholz, Frank
Publicado 2023

A heterodimer of evolved designer-recombinases precisely excises a human genomic DNA locus

por Lansing, Felix, Paszkowski-Rogacz, Maciej, Schmitt, Lukas Theo, Schneider, Paul Martin, Rojo Romanos, Teresa, Sonntag, Jan, Buchholz, Frank
Publicado 2020

Quantification of evolved DNA-editing enzymes at scale with DEQSeq

por Schmitt, Lukas Theo, Schneider, Aksana, Posorski, Jonas, Lansing, Felix, Jelicic, Milica, Jain, Manavi, Sayed, Shady, Buchholz, Frank, Sürün, Duran
Publicado 2023

DNA methylation–independent long-term epigenetic silencing with dCRISPR/Cas9 fusion proteins

por Ding, Li, Schmitt, Lukas Theo, Brux, Melanie, Sürün, Duran, Augsburg, Martina, Lansing, Felix, Mircetic, Jovan, Theis, Mirko, Buchholz, Frank
Publicado 2022

Pairing of single mutations yields obligate Cre-type site-specific recombinases

por Hoersten, Jenna, Ruiz-Gómez, Gloria, Lansing, Felix, Rojo-Romanos, Teresa, Schmitt, Lukas Theo, Sonntag, Jan, Pisabarro, M Teresa, Buchholz, Frank
Publicado 2021

Correction of a Factor VIII genomic inversion with designer-recombinases

por Lansing, Felix, Mukhametzyanova, Liliya, Rojo-Romanos, Teresa, Iwasawa, Kentaro, Kimura, Masaki, Paszkowski-Rogacz, Maciej, Karpinski, Janet, Grass, Tobias, Sonntag, Jan, Schneider, Paul Martin, Günes, Ceren, Hoersten, Jenna, Schmitt, Lukas Theo, Rodriguez-Muela, Natalia, Knöfler, Ralf, Takebe, Takanori, Buchholz, Frank
Publicado 2022