Population Pharmacokinetics of Isavuconazole in Subjects with Mild or Moderate Hepatic Impairment

por Desai, Amit, Schmitt-Hoffmann, Anne-Hortense, Mujais, Salim, Townsend, Robert
Publicado 2016

Tissue Distribution and Elimination of Isavuconazole following Single and Repeat Oral-Dose Administration of Isavuconazonium Sulfate to Rats

por Schmitt-Hoffmann, Anne-Hortense, Kato, Kota, Townsend, Robert, Potchoiba, Michael J., Hope, William W., Andes, David, Spickermann, Jochen, Schneidkraut, Marlowe J.
Publicado 2017

Pharmacokinetic Evaluation of CYP3A4‐Mediated Drug‐Drug Interactions of Isavuconazole With Rifampin, Ketoconazole, Midazolam, and Ethinyl Estradiol/Norethindrone in Healthy Adults...

por Townsend, Robert, Dietz, Albert, Hale, Christine, Akhtar, Shahzad, Kowalski, Donna, Lademacher, Christopher, Lasseter, Kenneth, Pearlman, Helene, Rammelsberg, Diane, Schmitt‐Hoffmann, Anne, Yamazaki, Takao, Desai, Amit
Publicado 2016

Prediction of Safety Margin and Optimization of Dosing Protocol for a Novel Antibiotic using Quantitative Systems Pharmacology Modeling

por Woodhead, Jeffrey L., Paech, Franziska, Maurer, Martina, Engelhardt, Marc, Schmitt‐Hoffmann, Anne H., Spickermann, Jochen, Messner, Simon, Wind, Mathias, Witschi, Anne‐Therese, Krähenbühl, Stephan, Siler, Scott Q., Watkins, Paul B., Howell, Brett A.
Publicado 2018

Phase 1/2a trial of intravenous BAL101553, a novel controller of the spindle assembly checkpoint, in advanced solid tumours

por Kristeleit, Rebecca, Evans, Jeffry, Molife, L. Rhoda, Tunariu, Nina, Shaw, Heather, Slater, Sarah, Haris, Noor R. Md, Brown, Nicholas F., Forster, Martin D., Diamantis, Nikolaos, Rulach, Robert, Greystoke, Alastair, Asghar, Uzma, Rata, Mihaela, Anderson, Stephanie, Bachmann, Felix, Hannah, Alison, Kaindl, Thomas, Lane, Heidi A., Larger, Patrice J., Schmitt-Hoffmann, Anne, Engelhardt, Marc, Tzankov, Alexandar, Plummer, Ruth, Lopez, Juanita
Publicado 2020