The Emerging Role of RNA as a Therapeutic Target for Small Molecules

por Connelly, Colleen M., Moon, Michelle H., Schneekloth, John S.
Publicado 2016

Interrogating RNA–Small Molecule Interactions with Structure Probing and Artificial Intelligence-Augmented Molecular Simulations

por Wang, Yihang, Parmar, Shaifaly, Schneekloth, John S., Tiwary, Pratyush
Publicado 2022

DECODING COMPLEXITY IN BIOMOLECULAR RECOGNITION OF DNA I-MOTIFS

por Yazdani, Kamyar, Seshadri, Srinath, Tillo, Desiree, Vinson, Charles, Schneekloth, John S.
Publicado 2023

Targeting the RNA Polymerase I Transcription for Cancer Therapy Comes of Age

por Ferreira, Rita, Schneekloth, John S., Panov, Konstantin I., Hannan, Katherine M., Hannan, Ross D.
Publicado 2020

Custom G4 Microarrays Reveal Selective G-Quadruplex Recognition of Small Molecule BMVC: A Large-Scale Assessment of Ligand Binding Selectivity

por Wu, Guanhui, Tillo, Desiree, Ray, Sreejana, Chang, Ta-Chau, Schneekloth, John S., Vinson, Charles, Yang, Danzhou
Publicado 2020

Dysregulation of Hepatitis B Virus Nucleocapsid Assembly in vitro by RNA-binding Small Ligands

por Patel, Nikesh, Abulwerdi, Fardokht, Fatehi, Farzad, Manfield, Iain W., Le Grice, Stuart, Schneekloth, John S., Twarock, Reidun, Stockley, Peter G.
Publicado 2022

Dataset of high-throughput ligand screening against the RNA Packaging Signals regulating Hepatitis B Virus nucleocapsid formation

por Abulwerdi, Fardokht, Fatehi, Farzad, Manfield, Iain W., Le Grice, Stuart F.J., Schneekloth, John S., Twarock, Reidun, Stockley, Peter G., Patel, Nikesh
Publicado 2022

Identification of Biologically Active, HIV TAR RNA-Binding Small Molecules Using Small Molecule Microarrays

por Sztuba-Solinska, Joanna, Shenoy, Shilpa R., Gareiss, Peter, Krumpe, Lauren R. H., Le Grice, Stuart F. J., O’Keefe, Barry R., Schneekloth, John S.
Publicado 2014

Synthetic ligands for PreQ(1) riboswitches provide structural and mechanistic insights into targeting RNA tertiary structure

por Connelly, Colleen M., Numata, Tomoyuki, Boer, Robert E., Moon, Michelle H., Sinniah, Ranu S., Barchi, Joseph J., Ferré-D’Amaré, Adrian R., Schneekloth, John S.
Publicado 2019

HNRNPH1-dependent splicing of a fusion oncogene reveals a targetable RNA G-quadruplex interaction

por Neckles, Carla, Boer, Robert E., Aboreden, Nicholas, Cross, Allison M., Walker, Robert L., Kim, Bong-Hyun, Kim, Suntae, Schneekloth, John S., Caplen, Natasha J.
Publicado 2019

Small Molecule Microarrays Enable the Identification of a Selective, Quadruplex-Binding Inhibitor of MYC Expression

por Felsenstein, Kenneth M., Saunders, Lindsey B., Simmons, John K., Leon, Elena, Calabrese, David R., Zhang, Shuling, Michalowski, Aleksandra, Gareiss, Peter, Mock, Beverly A., Schneekloth, John S.
Publicado 2015

Small molecule microarray identifies inhibitors of tyrosyl-DNA phosphodiesterase 1 that simultaneously access the catalytic pocket and two substrate binding sites

por Zhao, Xue Zhi, Kiselev, Evgeny, Lountos, George T., Wang, Wenjie, Tropea, Joseph E., Needle, Danielle, Hilimire, Thomas A., Schneekloth, John S., Waugh, David S., Pommier, Yves, Burke, Terrence R.
Publicado 2021

Characterization of clinically used oral antiseptics as quadruplex-binding ligands

por Calabrese, David R, Zlotkowski, Katherine, Alden, Stephanie, Hewitt, William M, Connelly, Colleen M, Wilson, Robert M, Gaikwad, Snehal, Chen, Lu, Guha, Rajarshi, Thomas, Craig J, Mock, Beverly A, Schneekloth, John S
Publicado 2018

A Small Molecule Stabilizer of the MYC G4-Quadruplex Induces Endoplasmic Reticulum Stress, Senescence and Pyroptosis in Multiple Myeloma

por Gaikwad, Snehal M., Phyo, Zaw, Arteaga, Anaisa Quintanilla, Gorjifard, Sayeh, Calabrese, David R., Connors, Daniel, Huang, Jing, Michalowski, Aleksandra M., Zhang, Shuling, Liu, Zheng-Gang, Schneekloth, John S., Mock, Beverly A.
Publicado 2020

A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver

por Suzawa, Miyuki, Miranda, Diego A, Ramos, Karmela A, Ang, Kenny K-H, Faivre, Emily J, Wilson, Christopher G, Caboni, Laura, Arkin, Michelle R, Kim, Yeong-Sang, Fletterick, Robert J, Diaz, Aaron, Schneekloth, John S, Ingraham, Holly A
Publicado 2015

Proximity-Induced Nucleic Acid Degrader (PINAD) Approach to Targeted RNA Degradation Using Small Molecules

por Mikutis, Sigitas, Rebelo, Maria, Yankova, Eliza, Gu, Muxin, Tang, Cong, Coelho, Ana R., Yang, Mo, Hazemi, Madoka E., Pires de Miranda, Marta, Eleftheriou, Maria, Robertson, Max, Vassiliou, George S., Adams, David J., Simas, J. Pedro, Corzana, Francisco, Schneekloth, John S., Tzelepis, Konstantinos, Bernardes, Gonçalo J. L.
Publicado 2023

Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex

por Calabrese, David R., Chen, Xiang, Leon, Elena C., Gaikwad, Snehal M., Phyo, Zaw, Hewitt, William M., Alden, Stephanie, Hilimire, Thomas A., He, Fahu, Michalowski, Aleksandra M., Simmons, John K., Saunders, Lindsey B., Zhang, Shuling, Connors, Daniel, Walters, Kylie J., Mock, Beverly A., Schneekloth, John S.
Publicado 2018

Rescue of Transgenic Alzheimer’s Pathophysiology by Polymeric Cellular Prion Protein Antagonists

por Gunther, Erik C., Smith, Levi M., Kostylev, Mikhail A., Cox, Timothy O., Kaufman, Adam C., Lee, Suho, Folta-Stogniew, Ewa, Maynard, George D., Um, Ji Won, Stagi, Massimiliano, Heiss, Jacqueline K., Stoner, Austin, Noble, Geoff P., Takahashi, Hideyuki, Haas, Laura T., Schneekloth, John S., Merkel, Janie, Teran, Christopher, Naderi, Zahra K., Supattapone, Surachai, Strittmatter, Stephen M.
Publicado 2019