Orthotopic T-Cell Receptor Replacement—An “Enabler” for TCR-Based Therapies

por Schober, Kilian, Müller, Thomas R., Busch, Dirk H.
Publicado 2020

Orthotopic T-cell receptor replacement in primary human T cells using CRISPR-Cas9-mediated homology-directed repair

por Moosmann, Carolin, Müller, Thomas R., Busch, Dirk H., Schober, Kilian
Publicado 2021

The CMV-Specific CD8(+) T Cell Response Is Dominated by Supra-Public Clonotypes with High Generation Probabilities

por Schober, Kilian, Fuchs, Pim, Mir, Jonas, Hammel, Monika, Fanchi, Lorenzo, Flossdorf, Michael, Busch, Dirk H.
Publicado 2020

Th2 single-cell heterogeneity and clonal distribution at distant sites in helminth-infected mice

por Radtke, Daniel, Thuma, Natalie, Schülein, Christine, Kirchner, Philipp, Ekici, Arif B, Schober, Kilian, Voehringer, David
Publicado 2022

A T‐cell reporter platform for high‐throughput and reliable investigation of TCR function and biology

por Müller, Thomas R, Schuler, Corinna, Hammel, Monika, Köhler, Amelie, Jutz, Sabrina, Leitner, Judith, Schober, Kilian, Busch, Dirk H, Steinberger, Peter
Publicado 2020

Reactogenicity Correlates Only Weakly with Humoral Immunogenicity after COVID-19 Vaccination with BNT162b2 mRNA (Comirnaty(®))

por Held, Jürgen, Esse, Jan, Tascilar, Koray, Steininger, Philipp, Schober, Kilian, Irrgang, Pascal, Alsalameh, Rayya, Tenbusch, Matthias, Seggewies, Christof, Bogdan, Christian
Publicado 2021

Inventories of naive and tolerant mouse CD4 T cell repertoires reveal a hierarchy of deleted and diverted T cell receptors

por Hassler, Tobias, Urmann, Emanuel, Teschner, Sebastian, Federle, Christine, Dileepan, Thamotharampillai, Schober, Kilian, Jenkins, Marc K., Busch, Dirk H., Hinterberger, Maria, Klein, Ludger
Publicado 2019

Activation-inducible CAR expression enables precise control over engineered CAR T cell function

por Fraessle, Simon P., Tschulik, Claudia, Effenberger, Manuel, Cletiu, Vlad, Gerget, Maria, Schober, Kilian, Busch, Dirk H., Germeroth, Lothar, Stemberger, Christian, Poltorak, Mateusz P.
Publicado 2023

Long-term persistence and functionality of adoptively transferred antigen-specific T cells with genetically ablated PD-1 expression

por Dötsch, Sarah, Svec, Mortimer, Schober, Kilian, Hammel, Monika, Wanisch, Andreas, Gökmen, Füsun, Jarosch, Sebastian, Warmuth, Linda, Barton, Jack, Cicin-Sain, Luka, D’Ippolito, Elvira, Busch, Dirk H.
Publicado 2023

T cell-specific inactivation of mouse CD2 by CRISPR/Cas9

por Beil-Wagner, Jane, Dössinger, Georg, Schober, Kilian, vom Berg, Johannes, Tresch, Achim, Grandl, Martina, Palle, Pushpalatha, Mair, Florian, Gerhard, Markus, Becher, Burkhard, Busch, Dirk H., Buch, Thorsten
Publicado 2016

T Cells Directed against the Metastatic Driver Chondromodulin-1 in Ewing Sarcoma: Comparative Engineering with CRISPR/Cas9 vs. Retroviral Gene Transfer for Adoptive Transfer

por Xue, Busheng, von Heyking, Kristina, Gassmann, Hendrik, Poorebrahim, Mansour, Thiede, Melanie, Schober, Kilian, Mautner, Josef, Hauer, Julia, Ruland, Jürgen, Busch, Dirk H., Thiel, Uwe, Burdach, Stefan E. G.
Publicado 2022

Self-reactivity of CD8 T-cell clones determines their differentiation status rather than their responsiveness in infections

por Paprckova, Darina, Niederlova, Veronika, Moudra, Alena, Drobek, Ales, Pribikova, Michaela, Janusova, Sarka, Schober, Kilian, Neuwirth, Ales, Michalik, Juraj, Huranova, Martina, Horkova, Veronika, Cesnekova, Michaela, Simova, Michaela, Prochazka, Jan, Balounova, Jana, Busch, Dirk H., Sedlacek, Radislav, Schwarzer, Martin, Stepanek, Ondrej
Publicado 2022

Heterologous prime–boost vaccination with ChAdOx1 nCoV-19 and BNT162b2

por Tenbusch, Matthias, Schumacher, Sofie, Vogel, Emanuel, Priller, Alina, Held, Jürgen, Steininger, Philipp, Beileke, Stephanie, Irrgang, Pascal, Brockhoff, Ronja, Salmanton-García, Jon, Tinnefeld, Kathrin, Mijocevic, Hrvoje, Schober, Kilian, Bogdan, Christian, Yazici, Sarah, Knolle, Percy, Cornely, Oliver A, Überla, Klaus, Protzer, Ulrike
Publicado 2021

CMV seropositivity is a potential novel risk factor for severe COVID-19 in non-geriatric patients

por Weber, Simone, Kehl, Victoria, Erber, Johanna, Wagner, Karolin I., Jetzlsperger, Ana-Marija, Burrell, Teresa, Schober, Kilian, Schommers, Philipp, Augustin, Max, Crowell, Claudia S., Gerhard, Markus, Winter, Christof, Moosmann, Andreas, Spinner, Christoph D., Protzer, Ulrike, Hoffmann, Dieter, D’Ippolito, Elvira, Busch, Dirk H.
Publicado 2022

Targeted T cell receptor gene editing provides predictable T cell product function for immunotherapy

por Müller, Thomas R., Jarosch, Sebastian, Hammel, Monika, Leube, Justin, Grassmann, Simon, Bernard, Bettina, Effenberger, Manuel, Andrä, Immanuel, Chaudhry, M. Zeeshan, Käuferle, Theresa, Malo, Antje, Cicin-Sain, Luka, Steinberger, Peter, Feuchtinger, Tobias, Protzer, Ulrike, Schumann, Kathrin, Neuenhahn, Michael, Schober, Kilian, Busch, Dirk H.
Publicado 2021

Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells

por Horkova, Veronika, Drobek, Ales, Paprckova, Darina, Niederlova, Veronika, Prasai, Avishek, Uleri, Valeria, Glatzova, Daniela, Kraller, Markus, Cesnekova, Michaela, Janusova, Sarka, Salyova, Eva, Tsyklauri, Oksana, Kadlecek, Theresa A., Krizova, Katerina, Platzer, René, Schober, Kilian, Busch, Dirk H., Weiss, Arthur, Huppa, Johannes B., Stepanek, Ondrej
Publicado 2022

Class switch towards non-inflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination

por Irrgang, Pascal, Gerling, Juliane, Kocher, Katharina, Lapuente, Dennis, Steininger, Philipp, Habenicht, Katharina, Wytopil, Monika, Beileke, Stephanie, Schäfer, Simon, Zhong, Jahn, Ssebyatika, George, Krey, Thomas, Falcone, Valeria, Schülein, Christine, Peter, Antonia Sophia, Nganou-Makamdop, Krystelle, Hengel, Hartmut, Held, Jürgen, Bogdan, Christian, Überla, Klaus, Schober, Kilian, Winkler, Thomas H., Tenbusch, Matthias
Publicado 2022

Skin and gut imprinted T helper cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity

por Hiltensperger, Michael, Beltrán, Eduardo, Kant, Ravi, Tyystjärvi, Sofia, Lepennetier, Gildas, Moreno, Helena Domínguez, Bauer, Isabel J., Grassmann, Simon, Jarosch, Sebastian, Schober, Kilian, Buchholz, Veit R., Kenet, Selin, Gasperi, Christiane, Öllinger, Rupert, Rad, Roland, Muschaweckh, Andreas, Sie, Christopher, Aly, Lilian, Knier, Benjamin, Garg, Garima, Afzali, Ali M., Gerdes, Lisa Ann, Kümpfel, Tania, Franzenburg, Sören, Kawakami, Naoto, Hemmer, Bernhard, Busch, Dirk H., Misgeld, Thomas, Dornmair, Klaus, Korn, Thomas
Publicado 2021

Dynamics of humoral and cellular immune responses after homologous and heterologous SARS-CoV-2 vaccination with ChAdOx1 nCoV-19 and BNT162b2

por Vogel, Emanuel, Kocher, Katharina, Priller, Alina, Cheng, Cho-Chin, Steininger, Philipp, Liao, Bo-Hung, Körber, Nina, Willmann, Annika, Irrgang, Pascal, Held, Jürgen, Moosmann, Carolin, Schmidt, Viviane, Beileke, Stephanie, Wytopil, Monika, Heringer, Sarah, Bauer, Tanja, Brockhoff, Ronja, Jeske, Samuel, Mijocevic, Hrvoje, Christa, Catharina, Salmanton-García, Jon, Tinnefeld, Kathrin, Bogdan, Christian, Yazici, Sarah, Knolle, Percy, Cornely, Oliver A., Überla, Klaus, Protzer, Ulrike, Schober, Kilian, Tenbusch, Matthias
Publicado 2022

Systematic identification of cancer-specific MHC-binding peptides with RAVEN

por Baldauf, Michaela C., Gerke, Julia S., Kirschner, Andreas, Blaeschke, Franziska, Effenberger, Manuel, Schober, Kilian, Rubio, Rebeca Alba, Kanaseki, Takayuki, Kiran, Merve M., Dallmayer, Marlene, Musa, Julian, Akpolat, Nurset, Akatli, Ayse N., Rosman, Fernando C., Özen, Özlem, Sugita, Shintaro, Hasegawa, Tadashi, Sugimura, Haruhiko, Baumhoer, Daniel, Knott, Maximilian M. L., Sannino, Giuseppina, Marchetto, Aruna, Li, Jing, Busch, Dirk H., Feuchtinger, Tobias, Ohmura, Shunya, Orth, Martin F., Thiel, Uwe, Kirchner, Thomas, Grünewald, Thomas G. P.
Publicado 2018