Macrophage migration inhibitory factor is regulated by HIF-1α and cAMP and promotes renal cyst cell proliferation in a macrophage-independent manner

por Safi, Wajima, Kraus, Andre, Grampp, Steffen, Schödel, Johannes, Buchholz, Bjoern
Publicado 2020

Hypoxia induces polycystin-1 expression in the renal epithelium

por Grampp, Steffen, Kraus, Andre, Skoczynski, Kathrin, Schiffer, Mario, Krüger, René, Naas, Stephanie, Schödel, Johannes, Buchholz, Bjoern
Publicado 2023

Hypoxia controls expression of kidney-pathogenic MUC1 variants

por Naas, Stephanie, Krüger, René, Knaup, Karl Xaver, Naas, Julia, Grampp, Steffen, Schiffer, Mario, Wiesener, Michael, Schödel, Johannes
Publicado 2023

Loss of Polycystin-1 causes cAMP-dependent switch from tubule to cyst formation

por Scholz, Julia Katharina, Kraus, Andre, Lüder, Dominik, Skoczynski, Kathrin, Schiffer, Mario, Grampp, Steffen, Schödel, Johannes, Buchholz, Bjoern
Publicado 2022

Unlocking the complexity of hypoxia non-coding transcriptome landscape of breast cancer

por Choudhry, Hani, Schodel, Johannes, Albukhari, Ashwag, Oikonomopoulos, Spyros, Haider, Syed, Buffa, Francesca, Ragousis, Ioannis, Mole, David R, Harris, Adrian L
Publicado 2014

Extensive regulation of the non-coding transcriptome by hypoxia: role of HIF in releasing paused RNApol2

por Choudhry, Hani, Schödel, Johannes, Oikonomopoulos, Spyros, Camps, Carme, Grampp, Steffen, Harris, Adrian L, Ratcliffe, Peter J, Ragoussis, Jiannis, Mole, David R
Publicado 2014

Significance of Glomerular Immune Reactivity in Time Zero Biopsies for Allograft Survival Beyond IgA

por Vonbrunn, Eva, Serikova, Sofya, Daniel, Christoph, Amann, Kerstin, Schödel, Johannes, Buchholz, Björn, Ferrazzi, Fulvia, Heller, Katharina, Apel, Hendrik, Büttner-Herold, Maike
Publicado 2021

KidneyGPS: a user-friendly web application to help prioritize kidney function genes and variants based on evidence from genome-wide association studies

por Stanzick, Kira J., Stark, Klaus J., Gorski, Mathias, Schödel, Johannes, Krüger, René, Kronenberg, Florian, Warth, Richard, Heid, Iris M., Winkler, Thomas W.
Publicado 2023

The renal cancer risk allele at 14q24.2 activates a novel hypoxia-inducible transcription factor-binding enhancer of DPF3 expression

por Protze, Johanna, Naas, Stephanie, Krüger, René, Stöhr, Christine, Kraus, Andre, Grampp, Steffen, Wiesener, Michael, Schiffer, Mario, Hartmann, Arndt, Wullich, Bernd, Schödel, Johannes
Publicado 2022

Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression

por Schödel, Johannes, Bardella, Chiara, Sciesielski, Lina K, Brown, Jill M, Pugh, Chris W, Buckle, Veronica, Tomlinson, Ian P, Ratcliffe, Peter J, Mole, David R
Publicado 2012

Destruction of a distal hypoxia response element abolishes trans-activation of the PAG1 gene mediated by HIF-independent chromatin looping

por Schörg, Alexandra, Santambrogio, Sara, Platt, James L., Schödel, Johannes, Lindenmeyer, Maja T., Cohen, Clemens D., Schrödter, Katrin, Mole, David R., Wenger, Roland H., Hoogewijs, David
Publicado 2015

Distal and proximal hypoxia response elements co-operate to regulate organ-specific erythropoietin gene expression

por Orlando, Ilaria M. C., Lafleur, Véronique N., Storti, Federica, Spielmann, Patrick, Crowther, Lisa, Santambrogio, Sara, Schödel, Johannes, Hoogewijs, David, Mole, David R., Wenger, Roland H.
Publicado 2019

Unlocking the complexity of hypoxia non-coding transcriptome landscape of breast cancer

por Choudhry, Hani, Schodel, Johannes, Albukhari, Ashwag, Oikonomopoulos, Spyros, Haider, Syed, Moralli, Daniela, Camps, Carme, Buffa, Francesca, Ratcliffe, Peter, Ragousis, Ioannis, Mole, David R, Harris, Adrian L
Publicado 2014

Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway

por Grampp, Steffen, Schmid, Virginia, Salama, Rafik, Lauer, Victoria, Kranz, Franziska, Platt, James L., Smythies, James, Choudhry, Hani, Goppelt-Struebe, Margarete, Ratcliffe, Peter J., Mole, David R., Schödel, Johannes
Publicado 2017

Androglobin gene expression patterns and FOXJ1-dependent regulation indicate its functional association with ciliogenesis

por Koay, Teng Wei, Osterhof, Carina, Orlando, Ilaria M.C., Keppner, Anna, Andre, Daniel, Yousefian, Schayan, Suárez Alonso, María, Correia, Miguel, Markworth, Robert, Schödel, Johannes, Hankeln, Thomas, Hoogewijs, David
Publicado 2021

Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases

por Chan, Mun Chiang, Ilott, Nicholas E., Schödel, Johannes, Sims, David, Tumber, Anthony, Lippl, Kerstin, Mole, David R., Pugh, Christopher W., Ratcliffe, Peter J., Ponting, Chris P., Schofield, Christopher J.
Publicado 2016

Human AlkB Homologue 5 Is a Nuclear 2-Oxoglutarate Dependent Oxygenase and a Direct Target of Hypoxia-Inducible Factor 1α (HIF-1α)

por Thalhammer, Armin, Bencokova, Zuzana, Poole, Rachel, Loenarz, Christoph, Adam, Julie, O'Flaherty, Linda, Schödel, Johannes, Mole, David, Giaslakiotis, Konstantinos, Schofield, Christopher J., Hammond, Ester M., Ratcliffe, Peter J., Pollard, Patrick J.
Publicado 2011

Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer

por Grampp, Steffen, Platt, James L., Lauer, Victoria, Salama, Rafik, Kranz, Franziska, Neumann, Viviana K., Wach, Sven, Stöhr, Christine, Hartmann, Arndt, Eckardt, Kai-Uwe, Ratcliffe, Peter J., Mole, David R., Schödel, Johannes
Publicado 2016

Hypoxia drives glucose transporter 3 expression through hypoxia-inducible transcription factor (HIF)–mediated induction of the long noncoding RNA NICI

por Lauer, Victoria, Grampp, Steffen, Platt, James, Lafleur, Veronique, Lombardi, Olivia, Choudhry, Hani, Kranz, Franziska, Hartmann, Arndt, Wullich, Bernd, Yamamoto, Atsushi, Coleman, Mathew L., Ratcliffe, Peter J., Mole, David R., Schödel, Johannes
Publicado 2020

Renal Tubular HIF-2α Expression Requires VHL Inactivation and Causes Fibrosis and Cysts

por Schietke, Ruth E., Hackenbeck, Thomas, Tran, Maxine, Günther, Regina, Klanke, Bernd, Warnecke, Christina L., Knaup, Karl X., Shukla, Deepa, Rosenberger, Christian, Koesters, Robert, Bachmann, Sebastian, Betz, Peter, Schley, Gunnar, Schödel, Johannes, Willam, Carsten, Winkler, Thomas, Amann, Kerstin, Eckardt, Kai-Uwe, Maxwell, Patrick, Wiesener, Michael S.
Publicado 2012