Fluorinated Aromatic Amino Acids Are Sensitive (19)F NMR Probes for Bromodomain-Ligand Interactions

por Mishra, Neeraj K., Urick, Andrew K., Ember, Stuart W. J., Schönbrunn, Ernst, Pomerantz, William C.
Publicado 2014

Correction to Letter: Fluorinated Aromatic Amino Acids Are Sensitive (19)F NMR Probes for Bromodomain–Ligand Interactions

por Mishra, Neeraj K., Urick, Andrew K., Ember, Stuart W. J., Schönbrunn, Ernst, Pomerantz, William C.
Publicado 2016

Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4

por Allen, Bryce K., Mehta, Saurabh, Ember, Stewart W. J., Schonbrunn, Ernst, Ayad, Nagi, Schürer, Stephan C.
Publicado 2015

Identification of a Novel Class of BRD4 Inhibitors by Computational Screening and Binding Simulations

por Allen, Bryce K., Mehta, Saurabh, Ember, Stuart W. J., Zhu, Jin-Yi, Schönbrunn, Ernst, Ayad, Nagi G., Schürer, Stephan C.
Publicado 2017

Stability of the Human Hsp90-p50(Cdc37) Chaperone Complex against Nucleotides and Hsp90 Inhibitors, and the Influence of Phosphorylation by Casein Kinase 2

por Olesen, Sanne H., Ingles, Donna J., Zhu, Jin-Yi, Martin, Mathew P., Betzi, Stephane, Georg, Gunda I., Tash, Joseph S., Schönbrunn, Ernst
Publicado 2015

P-115: Unc-51 Like Kinase 3 protein (ULK3)-mediated autophagy is responsible for multiple myeloma resistance to chemotherapy

por Tauro, Marilena, Li, Tao, Meads, Mark, Sudalagunta, Praneeth, Alugubelli, Raghunandan Reddy, Lawrence, Nicholas, Schonbrunn, Ernst, Lawrence, Harshani, Shain, Kenneth, Lynch, Conor
Publicado 2022

Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors

por Ember, Stuart W. J., Zhu, Jin-Yi, Olesen, Sanne H., Martin, Mathew P., Becker, Andreas, Berndt, Norbert, Georg, Gunda I., Schönbrunn, Ernst
Publicado 2014

Development of WEE2 kinase inhibitors as novel non-hormonal female contraceptives that target meiosis

por Hanna, Carol B, Mudaliar, Deepti, John, Kristen, Allen, C Leigh, Sun, Luxin, Hawkinson, Jon E, Schönbrunn, Ernst, Georg, Gunda I, Jensen, Jeffrey T
Publicado 2020

Dual Aurora A and JAK2 kinase blockade effectively suppresses malignant transformation

por Yang, Hua, Lawrence, Harshani R., Kazi, Aslamuzzaman, Gevariya, Harsukh, Patel, Ronil, Luo, Yunting, Rix, Uwe, Schonbrunn, Ernst, Lawrence, Nicholas J., Sebti, Said M.
Publicado 2014

Structure–Activity Studies of N‐Butyl‐1‐deoxynojirimycin (NB‐DNJ) Analogues: Discovery of Potent and Selective Aminocyclopentitol Inhibitors of GBA1 and GBA2

por Gu, Xingxian, Gupta, Vijayalaxmi, Yang, Yan, Zhu, Jin‐Yi, Carlson, Erick J., Kingsley, Carolyn, Tash, Joseph S., Schönbrunn, Ernst, Hawkinson, Jon, Georg, Gunda I.
Publicado 2017

The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane

por Berndt, Norbert, Yang, Hua, Trinczek, Bernhard, Betzi, Stéphane, Zhang, Ziming, Wu, Bainan, Lawrence, Nicholas J., Pellecchia, Maurizio, Schönbrunn, Ernst, Cheng, Jin Q., Sebti, Saïd M.
Publicado 2010

Ack1 Mediated AKT/PKB Tyrosine 176 Phosphorylation Regulates Its Activation

por Mahajan, Kiran, Coppola, Domenico, Challa, Sridevi, Fang, Bin, Chen, Y. Ann, Zhu, Weiwei, Lopez, Alexis S., Koomen, John, Engelman, Robert W., Rivera, Charlene, Muraoka-Cook, Rebecca S., Cheng, Jin Q., Schönbrunn, Ernst, Sebti, Said M., Earp, H. Shelton, Mahajan, Nupam P.
Publicado 2010

Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding

por Faber, Erik B., Sun, Luxin, Tang, Jian, Roberts, Emily, Ganeshkumar, Sornakala, Wang, Nan, Rasmussen, Damien, Majumdar, Abir, Hirsch, Laura E., John, Kristen, Yang, An, Khalid, Hira, Hawkinson, Jon E., Levinson, Nicholas M., Chennathukuzhi, Vargheese, Harki, Daniel A., Schönbrunn, Ernst, Georg, Gunda I.
Publicado 2023

SARS-CoV-2 Period Seroprevalence and Related Factors, Hillsborough County, Florida, USA, October 2020–March 2021

por Giuliano, Anna R., Pilon-Thomas, Shari, Schell, Michael J., Abrahamsen, Martha, Islam, Jessica Y., Isaacs-Soriano, Kimberly, Kennedy, Kayoko, Dukes, Christopher W., Whiting, Junmin, Rathwell, Julie, Hensel, Jonathan A., Mangual, Leslie N., Schonbrunn, Ernst, Bikowitz, Melissa, Grassie, Dylan, Yang, Yan
Publicado 2022

EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma

por Durbin, Adam D., Wang, Tingjian, Wimalasena, Virangika K., Zimmerman, Mark W., Li, Deyao, Dharia, Neekesh V., Mariani, Luca, Shendy, Noha A.M., Nance, Stephanie, Patel, Anand G., Shao, Ying, Mundada, Maya, Maxham, Lily, Park, Paul M.C., Sigua, Logan H., Morita, Ken, Conway, Amy Saur, Robichaud, Amanda L., Perez-Atayde, Antonio R., Bikowitz, Melissa J., Quinn, Taylor R., Wiest, Olaf, Easton, John, Schönbrunn, Ernst, Bulyk, Martha L., Abraham, Brian J., Stegmaier, Kimberly, Look, A. Thomas, Qi, Jun
Publicado 2022