Characterization of a SARS-CoV-2 spike protein reference material

por Stocks, Bradley B., Thibeault, Marie-Pier, Schrag, Joseph D., Melanson, Jeremy E.
Publicado 2022

Corrigendum: Structure-guided design of a potent Clostridioides difficile toxin A inhibitor

por Hussack, Greg, Rossotti, Martin A., van Faassen, Henk, Murase, Tomohiko, Eugenio, Luiz, Schrag, Joseph D., Ng, Kenneth K.-S., Tanha, Jamshid
Publicado 2023

Structure-guided design of a potent Clostridioides difficile toxin A inhibitor

por Hussack, Greg, Rossotti, Martin A., van Faassen, Henk, Murase, Tomohiko, Eugenio, Luiz, Schrag, Joseph D., Ng, Kenneth K.-S., Tanha, Jamshid
Publicado 2023

Stability-Diversity Tradeoffs Impose Fundamental Constraints on Selection of Synthetic Human V(H)/V(L) Single-Domain Antibodies from In Vitro Display Libraries

por Henry, Kevin A., Kim, Dae Young, Kandalaft, Hiba, Lowden, Michael J., Yang, Qingling, Schrag, Joseph D., Hussack, Greg, MacKenzie, C. Roger, Tanha, Jamshid
Publicado 2017

Sequence tolerance of immunoglobulin variable domain framework regions to noncanonical intradomain disulfide linkages

por Kim, Dae Young, Kandalaft, Hiba, Lowden, Michael J., Yang, Qingling, Rossotti, Martin A., Robotham, Anna, Kelly, John F., Hussack, Greg, Schrag, Joseph D., Henry, Kevin A., Tanha, Jamshid
Publicado 2023

Antibody light chain variable domains and their biophysically improved versions for human immunotherapy

por Kim, Dae Young, To, Rebecca, Kandalaft, Hiba, Ding, Wen, van Faassen, Henk, Luo, Yan, Schrag, Joseph D, St-Amant, Nadereh, Hefford, Mary, Hirama, Tomoko, Kelly, John F, MacKenzie, Roger, Tanha, Jamshid
Publicado 2014

Structure-based engineering of pH-dependent antibody binding for selective targeting of solid-tumor microenvironment

por Sulea, Traian, Rohani, Nazanin, Baardsnes, Jason, Corbeil, Christopher R., Deprez, Christophe, Cepero-Donates, Yuneivy, Robert, Alma, Schrag, Joseph D., Parat, Marie, Duchesne, Mélanie, Jaramillo, Maria L., Purisima, Enrico O., Zwaagstra, John C.
Publicado 2019

Binding symmetry and surface flexibility mediate antibody self-association

por Schrag, Joseph D., Picard, Marie-Ève, Gaudreault, Francis, Gagnon, Louis-Patrick, Baardsnes, Jason, Manenda, Mahder S., Sheff, Joey, Deprez, Christophe, Baptista, Cassio, Hogues, Hervé, Kelly, John F., Purisima, Enrico O., Shi, Rong, Sulea, Traian
Publicado 2019

Influence of variant-specific mutations, temperature and pH on conformations of a large set of SARS-CoV-2 spike trimer vaccine antigen candidates

por Stuible, Matthew, Schrag, Joseph D., Sheff, Joey, Zoubchenok, Daria, Lord-Dufour, Simon, Cass, Brian, L’Abbé, Denis, Pelletier, Alex, Rossotti, Martin A., Tanha, Jamshid, Gervais, Christian, Maurice, Roger, El Bakkouri, Majida, Acchione, Mauro, Durocher, Yves
Publicado 2023

An anti-HER2 biparatopic antibody that induces unique HER2 clustering and complement-dependent cytotoxicity

por Weisser, Nina E., Sanches, Mario, Escobar-Cabrera, Eric, O’Toole, Jason, Whalen, Elizabeth, Chan, Peter W. Y., Wickman, Grant, Abraham, Libin, Choi, Kate, Harbourne, Bryant, Samiotakis, Antonios, Rojas, Andrea Hernández, Volkers, Gesa, Wong, Jodi, Atkinson, Claire E., Baardsnes, Jason, Worrall, Liam J., Browman, Duncan, Smith, Emma E., Baichoo, Priya, Cheng, Chi Wing, Guedia, Joy, Kang, Sohyeong, Mukhopadhyay, Abhishek, Newhook, Lisa, Ohrn, Anders, Raghunatha, Prajwal, Zago-Schmitt, Matteo, Schrag, Joseph D., Smith, Joel, Zwierzchowski, Patricia, Scurll, Joshua M., Fung, Vincent, Black, Sonia, Strynadka, Natalie C. J., Gold, Michael R., Presta, Leonard G., Ng, Gordon, Dixit, Surjit
Publicado 2023