Immucillin-H, a purine nucleoside phosphorylase transition state analog, causes non-lethal attenuation of growth in Staphylococcus aureus

por Stratton, Christopher F, Schramm, Vern L
Publicado 2013

Catalytic Site Cooperativity in Dimeric Methylthioadenosine Nucleosidase

por Wang, Shanzhi, Thomas, Keisha, Schramm, Vern L.
Publicado 2014

Transition-State Analysis of 2-O-Acetyl-ADP-Ribose Hydrolysis by Human Macrodomain 1

por Hirsch, Brett M., Burgos, Emmanuel S., Schramm, Vern L.
Publicado 2014

A resistant mutant of Plasmodium falciparum purine nucleoside phosphorylase uses wild-type neighbors to maintain parasite survival

por Minnow, Yacoba V.T., Harijan, Rajesh K., Schramm, Vern L.
Publicado 2021

Clostridioides difficile TcdB Toxin Glucosylates Rho GTPase by an S(N)i Mechanism and Ion Pair Transition State

por Paparella, Ashleigh S., Cahill, Sean M., Aboulache, Briana L., Schramm, Vern L.
Publicado 2022

Protein Mass-Modulated Effects in the Catalytic Mechanism of Dihydrofolate Reductase: Beyond Promoting Vibrations

por Wang, Zhen, Singh, Priyanka, Czekster, Clarissa M., Kohen, Amnon, Schramm, Vern L.
Publicado 2014

Transition state analogue of MTAP extends lifespan of APC(Min/+) mice

por Firestone, Ross S., Feng, Mu, Basu, Indranil, Peregrina, Karina, Augenlicht, Leonard H., Schramm, Vern L.
Publicado 2021

Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues

por Paparella, Ashleigh S., Aboulache, Briana L., Harijan, Rajesh K., Potts, Kathryn S., Tyler, Peter C., Schramm, Vern L.
Publicado 2021

Transition state analogues of 5′-methylthioadenosine nucleosidase disrupt quorum sensing

por Gutierrez, Jemy A., Crowder, Tamara, Rinaldo-Matthis, Agnes, Ho, Meng-Chiao, Almo, Steven C., Schramm, Vern L.
Publicado 2009

Isofagomine inhibits multiple TcdB variants and protects mice from Clostridioides difficile induced mortality

por Paparella, Ashleigh S., Brew, Isabella, Hong, Huynh A., Ferriera, William, Cutting, Simon, Lamiable-Oulaidi, Farah, Popadynec, Michael, Tyler, Peter C., Schramm, Vern L.
Publicado 2023

Immucillins Impair Leishmania (L.) infantum chagasi and Leishmania (L.) amazonensis Multiplication In Vitro

por Freitas, Elisangela Oliveira, Nico, Dirlei, Guan, Rong, Meyer-Fernandes, José Roberto, Clinch, Keith, Evans, Gary B., Tyler, Peter C., Schramm, Vern L., Palatnik-de-Sousa, Clarisa B.
Publicado 2015

Immucillins ImmA and ImmH Are Effective and Non-toxic in the Treatment of Experimental Visceral Leishmaniasis

por Freitas, Elisangela Oliveira, Nico, Dirlei, Alves-Silva, Marcus Vinícius, Morrot, Alexandre, Clinch, Keith, Evans, Gary B., Tyler, Peter C., Schramm, Vern L., Palatnik-de-Sousa, Clarisa B.
Publicado 2015

Kinetic Characterization and Inhibition of Trypanosoma cruzi Hypoxanthine–Guanine Phosphoribosyltransferases

por Glockzin, Kayla, Kostomiris, Demetrios, Minnow, Yacoba V. T., Suthagar, Kajitha, Clinch, Keith, Gai, Sinan, Buckler, Joshua N., Schramm, Vern L., Tyler, Peter C., Meek, Thomas D., Katzfuss, Ardala
Publicado 2022

Plasmodium falciparum Parasites Are Killed by a Transition State Analogue of Purine Nucleoside Phosphorylase in a Primate Animal Model

por Cassera, María B., Hazleton, Keith Z., Merino, Emilio F., Obaldia, Nicanor, Ho, Meng-Chiao, Murkin, Andrew S., DePinto, Richard, Gutierrez, Jemy A., Almo, Steven C., Evans, Gary B., Babu, Yarlagadda S., Schramm, Vern L.
Publicado 2011