On the prevention of kidney uptake of radiolabeled DARPins

por Altai, Mohamed, Garousi, Javad, Rinne, Sara S., Schulga, Alexey, Deyev, Sergey, Vorobyeva, Anzhelika
Publicado 2020

Visualization of epithelial cell adhesion molecule-expressing renal cell carcinoma xenografts using designed ankyrin repeat protein Ec1 labelled with (99m)Tc and (125)I

por Tolmachev, Vladimir, Bodenko, Vitalina, Orlova, Anna, Schulga, Alexey, Deyev, Sergey M., Vorobyeva, Anzhelika
Publicado 2022

Indirect Radioiodination of DARPin G3 Using N-succinimidyl-Para-Iodobenzoate Improves the Contrast of HER2 Molecular Imaging

por Vorobyeva, Anzhelika, Schulga, Alexey, Rinne, Sara S., Günther, Tyran, Orlova, Anna, Deyev, Sergey, Tolmachev, Vladimir
Publicado 2019

Epithelial cell adhesion molecule-targeting designed ankyrin repeat protein-toxin fusion Ec1-LoPE exhibits potent cytotoxic action in prostate cancer cells

por Xu, Tianqi, Liu, Yongsheng, Schulga, Alexey, Konovalova, Elena, Deyev, Sergey M., Tolmachev, Vladimir, Vorobyeva, Anzhelika
Publicado 2022

Direct Intra-Patient Comparison of Scaffold Protein-Based Tracers, [(99m)Tc]Tc-ADAPT6 and [(99m)Tc]Tc-(HE)(3)-G3, for Imaging of HER2-Positive Breast Cancer

por Bragina, Olga, Chernov, Vladimir, Schulga, Alexey, Konovalova, Elena, Hober, Sophia, Deyev, Sergey, Sörensen, Jens, Tolmachev, Vladimir
Publicado 2023

Penetration Efficiency of Antitumor Agents in Ovarian Cancer Spheroids: The Case of Recombinant Targeted Toxin DARPin-LoPE and the Chemotherapy Drug, Doxorubicin

por Sokolova, Evgeniya, Kutova, Olga, Grishina, Alena, Pospelov, Anton, Guryev, Evgeniy, Schulga, Alexey, Deyev, Sergey, Balalaeva, Irina
Publicado 2019

HER2-Specific Targeted Toxin DARPin-LoPE: Immunogenicity and Antitumor Effect on Intraperitoneal Ovarian Cancer Xenograft Model

por Sokolova, Evgeniya A., Shilova, Olga N., Kiseleva, Daria V., Schulga, Alexey A., Balalaeva, Irina V., Deyev, Sergey M.
Publicado 2019

Feasibility of Imaging EpCAM Expression in Ovarian Cancer Using Radiolabeled DARPin Ec1

por Vorobyeva, Anzhelika, Konovalova, Elena, Xu, Tianqi, Schulga, Alexey, Altai, Mohamed, Garousi, Javad, Rinne, Sara S., Orlova, Anna, Tolmachev, Vladimir, Deyev, Sergey
Publicado 2020

Radionuclide Molecular Imaging of EpCAM Expression in Triple-Negative Breast Cancer Using the Scaffold Protein DARPin Ec1

por Vorobyeva, Anzhelika, Bezverkhniaia, Ekaterina, Konovalova, Elena, Schulga, Alexey, Garousi, Javad, Vorontsova, Olga, Abouzayed, Ayman, Orlova, Anna, Deyev, Sergey, Tolmachev, Vladimir
Publicado 2020

Binase treatment increases interferon sensitivity and apoptosis in SiHa cervical carcinoma cells by downregulating E6 and E7 human papilloma virus oncoproteins

por Mitkevich, Vladimir A., Burnysheva, Ksenia M., Petrushanko, Irina Yu, Adzhubei, Alexei A., Schulga, Alexey A., Chumakov, Peter M., Makarov, Alexander A.
Publicado 2017

Data on characterization of magnetic nanoparticles stabilized with fusion protein of Barstar and C-term part of Mms6

por Shipunova, Victoria O., Kotelnikova, Polina A., Aghayeva, Ulkar F., Stremovskiy, Oleg A., Schulga, Alexey A., Nikitin, Maxim P., Deyev, Sergey M.
Publicado 2018

Feasibility of Co-Targeting HER3 and EpCAM Using Seribantumab and DARPin–Toxin Fusion in a Pancreatic Cancer Xenograft Model

por Xu, Tianqi, Schulga, Alexey, Konovalova, Elena, Rinne, Sara S., Zhang, Hongchao, Vorontsova, Olga, Orlova, Anna, Deyev, Sergey M., Tolmachev, Vladimir, Vorobyeva, Anzhelika
Publicado 2023

Direct In Vivo Comparison of (99m)Tc-Labeled Scaffold Proteins, DARPin G3 and ADAPT6, for Visualization of HER2 Expression and Monitoring of Early Response for Trastuzumab Therapy

por Tolmachev, Vladimir, Bodenko, Vitalina, Oroujeni, Maryam, Deyev, Sergey, Konovalova, Elena, Schulga, Alexey, Lindbo, Sarah, Hober, Sophia, Bragina, Olga, Orlova, Anna, Vorobyeva, Anzhelika
Publicado 2022

Imaging-Guided Therapy Simultaneously Targeting HER2 and EpCAM with Trastuzumab and EpCAM-Directed Toxin Provides Additive Effect in Ovarian Cancer Model

por Xu, Tianqi, Vorobyeva, Anzhelika, Schulga, Alexey, Konovalova, Elena, Vorontsova, Olga, Ding, Haozhong, Gräslund, Torbjörn, Tashireva, Liubov A., Orlova, Anna, Tolmachev, Vladimir, Deyev, Sergey M.
Publicado 2021

Optimal composition and position of histidine-containing tags improves biodistribution of (99m)Tc-labeled DARPin G3

por Vorobyeva, Anzhelika, Schulga, Alexey, Konovalova, Elena, Güler, Rezan, Löfblom, John, Sandström, Mattias, Garousi, Javad, Chernov, Vladimir, Bragina, Olga, Orlova, Anna, Tolmachev, Vladimir, Deyev, Sergey M.
Publicado 2019

Phase I Trial of (99m)Tc-(HE)(3)-G3, a DARPin-Based Probe for Imaging of HER2 Expression in Breast Cancer

por Bragina, Olga, Chernov, Vladimir, Schulga, Alexey, Konovalova, Elena, Garbukov, Eugeniy, Vorobyeva, Anzhelika, Orlova, Anna, Tashireva, Liubov, Sörensen, Jens, Zelchan, Roman, Medvedeva, Anna, Deyev, Sergey, Tolmachev, Vladimir
Publicado 2022

Influence of the Position and Composition of Radiometals and Radioiodine Labels on Imaging of Epcam Expression in Prostate Cancer Model Using the DARPin Ec1

por Deyev, Sergey M., Xu, Tianqi, Liu, Yongsheng, Schulga, Alexey, Konovalova, Elena, Garousi, Javad, Rinne, Sara S., Larkina, Maria, Ding, Haozhong, Gräslund, Torbjörn, Orlova, Anna, Tolmachev, Vladimir, Vorobyeva, Anzhelika
Publicado 2021

Comparative Preclinical Evaluation of Peptide-Based Chelators for the Labeling of DARPin G3 with (99m)Tc for Radionuclide Imaging of HER2 Expression in Cancer

por Larkina, Mariia, Plotnikov, Evgenii, Bezverkhniaia, Ekaterina, Shabanova, Yulia, Tretyakova, Maria, Yuldasheva, Feruza, Zelchan, Roman, Schulga, Alexey, Konovalova, Elena, Vorobyeva, Anzhelika, Garousi, Javad, Gräslund, Torbjörn, Belousov, Mikhail, Tolmachev, Vladimir, Deyev, Sergey
Publicado 2022

Accessing Mitochondrial Protein Import in Living Cells by Protein Microinjection

por Bogorodskiy, Andrey, Okhrimenko, Ivan, Maslov, Ivan, Maliar, Nina, Burkatovskii, Dmitrii, von Ameln, Florian, Schulga, Alexey, Jakobs, Philipp, Altschmied, Joachim, Haendeler, Judith, Katranidis, Alexandros, Sorokin, Ivan, Mishin, Alexey, Gordeliy, Valentin, Büldt, Georg, Voos, Wolfgang, Gensch, Thomas, Borshchevskiy, Valentin
Publicado 2021

UCNP-based Photoluminescent Nanomedicines for Targeted Imaging and Theranostics of Cancer

por Guryev, Evgenii L., Smyshlyaeva, Anita S., Shilyagina, Natalia Y., Sokolova, Evgeniya A., Shanwar, Samah, Kostyuk, Alexey B., Lyubeshkin, Alexander V., Schulga, Alexey A., Konovalova, Elena V., Lin, Quan, Roy, Indrajit, Balalaeva, Irina V., Deyev, Sergey M., Zvyagin, Andrei V.
Publicado 2020