SUN-662 Praliciguat, a Clinical-Stage Soluble Guanylate Cyclase Stimulator, Improves Lipid Handling and Insulin Sensitivity in Diet-Induced Obese Mice

por Schwartzkopf, Chad D, Liu, Guang, Hadcock, John R, Currie, Mark G, Masferrer, Jamie L, Jones, Juli E
Publicado 2020

Beneficial Metabolic Effects of Praliciguat, a Soluble Guanylate Cyclase Stimulator, in a Mouse Diet-Induced Obesity Model

por Schwartzkopf, Chad D., Hadcock, John R., Liu, Guang, Germano, Peter, Roux, Julien, Shea, Courtney M., Buys, Emmanuel S., Jones, Juli E.
Publicado 2022

SGLT2 inhibition potentiates the cardiovascular, renal, and metabolic effects of sGC stimulation in hypertensive rats with prolonged exposure to high-fat diet

por Reverte, Virginia, Rodriguez, Francisca, Oltra, Lidia, Moreno, Juan M., Llinás, María T., Shea, Courtney M., Schwartzkopf, Chad D., Buys, Emmanuel S., Masferrer, Jaime L., Salazar, F. Javier
Publicado 2022

The CNS-penetrant soluble guanylate cyclase stimulator CYR119 attenuates markers of inflammation in the central nervous system

por Correia, Susana S., Liu, Guang, Jacobson, Sarah, Bernier, Sylvie G., Tobin, Jenny V., Schwartzkopf, Chad D., Atwater, Emily, Lonie, Elisabeth, Rivers, Sam, Carvalho, Andrew, Germano, Peter, Tang, Kim, Iyengar, Rajesh R., Currie, Mark G., Hadcock, John R., Winrow, Christopher J., Jones, Juli E.
Publicado 2021

The CNS-Penetrant Soluble Guanylate Cyclase Stimulator CY6463 Reveals its Therapeutic Potential in Neurodegenerative Diseases

por Correia, Susana S., Iyengar, Rajesh R., Germano, Peter, Tang, Kim, Bernier, Sylvie G., Schwartzkopf, Chad D., Tobin, Jenny, Lee, Thomas W.-H., Liu, Guang, Jacobson, Sarah, Carvalho, Andrew, Rennie, Glen R., Jung, Joon, Renhowe, Paul A., Lonie, Elisabeth, Winrow, Christopher J., Hadcock, John R., Jones, Juli E., Currie, Mark G.
Publicado 2021