Multiplexing of receptor occupancy measurements for pharmacodynamic biomarker assessment of biopharmaceuticals

por Vainshtein, Inna, Schneider, Amy K., Sun, Bo, Schwickart, Martin, Roskos, Lorin K., Liang, Meina
Publicado 2015

Receptor occupancy assessment by flow cytometry as a pharmacodynamic biomarker in biopharmaceutical development

por Liang, Meina, Schwickart, Martin, Schneider, Amy K., Vainshtein, Inna, Del Nagro, Christopher, Standifer, Nathan, Roskos, Lorin K.
Publicado 2015

Evaluation of assay interference and interpretation of CXCR4 receptor occupancy results in a preclinical study with MEDI3185, a fully human antibody to CXCR4

por Schwickart, Martin, Chavez, Carlos, Henderson, Simon, Vainshtein, Inna, Standifer, Nathan, DelNagro, Christopher, Mehrzai, Freshta, Schneider, Amy, Roskos, Lorin, Liang, Meina
Publicado 2015

MEDI1873, a potent, stabilized hexameric agonist of human GITR with regulatory T-cell targeting potential

por Tigue, Natalie J., Bamber, Lisa, Andrews, John, Ireland, Samantha, Hair, James, Carter, Edward, Sridharan, Sudharsan, Jovanović, Jelena, Rees, D. Gareth, Springall, Jeremy S., Solier, Emilie, Li, Yi-Ming, Chodorge, Matthieu, Perez-Martinez, David, Higazi, Daniel R., Oberst, Michael, Kennedy, Maureen, Black, Chelsea M., Yan, Li, Schwickart, Martin, Maguire, Shaun, Cann, Jennifer A., de Haan, Lolke, Young, Lesley L., Vaughan, Tristan, Wilkinson, Robert W., Stewart, Ross
Publicado 2017