Resolving patient heterogeneity in critical illness requires multi-scale approaches

por Scicluna, Brendon P.
Publicado 2022

The Search for Efficacious New Therapies in Sepsis Needs to Embrace Heterogeneity

por Scicluna, Brendon P., Baillie, J. Kenneth
Publicado 2019

Interleukin-27: a potential new sepsis biomarker exposed through genome-wide transcriptional profiling

por Scicluna, Brendon P, van der Poll, Tom
Publicado 2012

The Role of Host Cell DNA Methylation in the Immune Response to Bacterial Infection

por Qin, Wanhai, Scicluna, Brendon P., van der Poll, Tom
Publicado 2021

Genetic signature related to heme-hemoglobin metabolism pathway in sepsis secondary to pneumonia

por Leite, Giuseppe Gianini Figuerêido, Scicluna, Brendon P., van der Poll, Tom, Salomão, Reinaldo
Publicado 2019

Myeloid DNA methyltransferase3b deficiency aggravates pulmonary fibrosis by enhancing profibrotic macrophage activation

por Qin, Wanhai, Spek, C. Arnold, Scicluna, Brendon P., van der Poll, Tom, Duitman, JanWillem
Publicado 2022

Protease‐activated receptor 1 drives and maintains ductal cell fates in the premalignant pancreas and ductal adenocarcinoma

por Tekin, Cansu, Scicluna, Brendon P., Lodestijn, Sophie C., Shi, Kun, Bijlsma, Maarten F., Spek, C. Arnold
Publicado 2021

DNA Methyltransferase 3b in Myeloid Cells Does Not Affect the Acute Immune Response in the Airways during Pseudomonas Pneumonia

por Qin, Wanhai, Brands, Xanthe, van’t Veer, Cornelis, de Vos, Alex F., Scicluna, Brendon P., van der Poll, Tom
Publicado 2022

Role of Tumor Necrosis Factor-α in the Human Systemic Endotoxin-Induced Transcriptome

por Scicluna, Brendon P., van 't Veer, Cornelis, Nieuwdorp, Max, Felsmann, Karen, Wlotzka, Britta, Stroes, Erik S. G., van der Poll, Tom
Publicado 2013

Myeloid miR-155 plays a limited role in antibacterial defense during Klebsiella-derived pneumosepsis and is dispensable for lipopolysaccharide- or Klebsiella-induced inflammation i...

por Qin, Wanhai, Saris, Anno, van ’t Veer, Cornelis, Roelofs, Joris J T H, Scicluna, Brendon P, de Vos, Alex F, van der Poll, Tom
Publicado 2023

Matrix metalloproteinase-8: a useful biomarker to refine the diagnosis of community-acquired pneumonia upon intensive care unit admission?

por Uhel, Fabrice, Scicluna, Brendon P., van Vught, Lonneke A., Cremer, Olaf L., Bonten, Marc J., Schultz, Marcus J., van der Poll, Tom
Publicado 2019

Tenascin-C Deficiency Is Associated With Reduced Bacterial Outgrowth During Klebsiella pneumoniae-Evoked Pneumosepsis in Mice

por Meijer, Mariska T., de Vos, Alex F., Scicluna, Brendon P., Roelofs, Joris J., Abou Fayçal, Chérine, Orend, Gertraud, Uhel, Fabrice, van der Poll, Tom
Publicado 2021

Association between delay in intensive care unit admission and the host response in patients with community-acquired pneumonia

por Pereverzeva, Liza, Uhel, Fabrice, Peters Sengers, Hessel, Cremer, Olaf L., Schultz, Marcus J., Bonten, Marc M. J., Scicluna, Brendon P., van der Poll, Tom
Publicado 2021

Human Adipose‐Derived Mesenchymal Stem Cells Modify Lung Immunity and Improve Antibacterial Defense in Pneumosepsis Caused by Klebsiella pneumoniae

por Perlee, Desiree, de Vos, Alex F., Scicluna, Brendon P., Mancheño, Pablo, de la Rosa, Olga, Dalemans, Wilfried, Nürnberg, Peter, Lombardo, Eleuterio, van der Poll, Tom
Publicado 2019

Bronchial epithelial DNA methyltransferase 3b dampens pulmonary immune responses during Pseudomonas aeruginosa infection

por Qin, Wanhai, Brands, Xanthe, van’t Veer, Cornelis, F. de Vos, Alex, Sirard, Jean-Claude, J. T. H. Roelofs, Joris, P. Scicluna, Brendon, van der Poll, Tom
Publicado 2021

Concurrent Immune Suppression and Hyperinflammation in Patients With Community-Acquired Pneumonia

por Brands, Xanthe, Haak, Bastiaan W., Klarenbeek, Augustijn M., Otto, Natasja A., Faber, Daniël R., Lutter, René, Scicluna, Brendon P., Wiersinga, W. Joost, van der Poll, Tom
Publicado 2020

Corrigendum: Concurrent Immune Suppression and Hyperinflammation in Patients With Community-Acquired Pneumonia

por Brands, Xanthe, Haak, Bastiaan W., Klarenbeek, Augustijn M., Otto, Natasja A., Faber, Daniël R., Lutter, René, Scicluna, Brendon P., Wiersinga, W. Joost, van der Poll, Tom
Publicado 2020

Tenascin C Has a Modest Protective Effect on Acute Lung Pathology during Methicillin-Resistant Staphylococcus aureus-Induced Pneumonia in Mice

por Meijer, Mariska T., de Vos, Alex F., Peters Sengers, Hessel, Scicluna, Brendon P., Roelofs, Joris J., Abou Fayçal, Chérine, Uhel, Fabrice, Orend, Gertraud, van der Poll, Tom
Publicado 2021

Immune suppression is associated with enhanced systemic inflammatory, endothelial and procoagulant responses in critically ill patients

por Brands, Xanthe, Uhel, Fabrice, van Vught, Lonneke A., Wiewel, Maryse A., Hoogendijk, Arie J., Lutter, René, Schultz, Marcus J., Scicluna, Brendon P., van der Poll, Tom
Publicado 2022

Mortality and host response aberrations associated with transient and persistent acute kidney injury in critically ill patients with sepsis: a prospective cohort study

por Uhel, Fabrice, Peters-Sengers, Hessel, Falahi, Fahimeh, Scicluna, Brendon P., van Vught, Lonneke A., Bonten, Marc J., Cremer, Olaf L., Schultz, Marcus J., van der Poll, Tom
Publicado 2020