Transcriptional targets of amyotrophic lateral sclerosis/frontotemporal dementia protein TDP-43 – meta-analysis and interactive graphical database

por Cao, Maize C., Scotter, Emma L.
Publicado 2022

TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets

por Scotter, Emma L., Chen, Han-Jou, Shaw, Christopher E.
Publicado 2015

Shared Regulatory Pathways Reveal Novel Genetic Correlations Between Grip Strength and Neuromuscular Disorders

por Gokuladhas, Sreemol, Schierding, William, Cameron-Smith, David, Wake, Melissa, Scotter, Emma L., O’Sullivan, Justin
Publicado 2020

Cytoplasmic TDP-43 is involved in cell fate during stress recovery

por Lee, Youn-Bok, Scotter, Emma L, Lee, Do-Young, Troakes, Claire, Mitchell, Jacqueline, Rogelj, Boris, Gallo, Jean-Marc, Shaw, Christopher E
Publicado 2021

Serum biomarkers of neuroinflammation and blood-brain barrier leakage in amyotrophic lateral sclerosis

por Cao, Maize C., Cawston, Erin E., Chen, Grace, Brooks, Collin, Douwes, Jeroen, McLean, Dave, Graham, E. Scott, Dragunow, Mike, Scotter, Emma L.
Publicado 2022

The heat shock response plays an important role in TDP-43 clearance: evidence for dysfunction in amyotrophic lateral sclerosis

por Chen, Han-Jou, Mitchell, Jacqueline C., Novoselov, Sergey, Miller, Jack, Nishimura, Agnes L., Scotter, Emma L., Vance, Caroline A., Cheetham, Michael E., Shaw, Christopher E.
Publicado 2016

Microglial CD68 and L-ferritin upregulation in response to phosphorylated-TDP-43 pathology in the amyotrophic lateral sclerosis brain

por Swanson, Molly E. V., Mrkela, Miran, Murray, Helen C., Cao, Maize C., Turner, Clinton, Curtis, Maurice A., Faull, Richard L. M., Walker, Adam K., Scotter, Emma L.
Publicado 2023

Modelling physiological and pathological conditions to study pericyte biology in brain function and dysfunction

por Rustenhoven, Justin, Smyth, Leon C., Jansson, Deidre, Schweder, Patrick, Aalderink, Miranda, Scotter, Emma L., Mee, Edward W., Faull, Richard L. M., Park, Thomas I.-H., Dragunow, Mike
Publicado 2018

Identification of a dysfunctional microglial population in human Alzheimer’s disease cortex using novel single-cell histology image analysis

por Swanson, Molly E. V., Scotter, Emma L., Smyth, Leon C. D., Murray, Helen C., Ryan, Brigid, Turner, Clinton, Faull, Richard L. M., Dragunow, Mike, Curtis, Maurice A.
Publicado 2020

Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species

por Scotter, Emma L., Vance, Caroline, Nishimura, Agnes L., Lee, Youn-Bok, Chen, Han-Jou, Urwin, Hazel, Sardone, Valentina, Mitchell, Jacqueline C., Rogelj, Boris, Rubinsztein, David C., Shaw, Christopher E.
Publicado 2014

Interferon-γ blocks signalling through PDGFRβ in human brain pericytes

por Jansson, Deidre, Scotter, Emma L., Rustenhoven, Justin, Coppieters, Natacha, Smyth, Leon C. D., Oldfield, Robyn L., Bergin, Peter S., Mee, Edward W., Graham, E. Scott, Faull, Richard L. M., Dragunow, Mike
Publicado 2016

ALS mutant FUS disrupts nuclear localization and sequesters wild-type FUS within cytoplasmic stress granules

por Vance, Caroline, Scotter, Emma L., Nishimura, Agnes L., Troakes, Claire, Mitchell, Jacqueline C., Kathe, Claudia, Urwin, Hazel, Manser, Catherine, Miller, Christopher C., Hortobágyi, Tibor, Dragunow, Mike, Rogelj, Boris, Shaw, Christopher E.
Publicado 2013

TGF-beta1 regulates human brain pericyte inflammatory processes involved in neurovasculature function

por Rustenhoven, Justin, Aalderink, Miranda, Scotter, Emma L., Oldfield, Robyn L., Bergin, Peter S., Mee, Edward W., Graham, E. Scott, Faull, Richard L. M., Curtis, Maurice A., Park, Thomas I-H., Dragunow, Mike
Publicado 2016

An anti-inflammatory role for C/EBPδ in human brain pericytes

por Rustenhoven, Justin, Scotter, Emma L., Jansson, Deidre, Kho, Dan T., Oldfield, Robyn L., Bergin, Peter S., Mee, Edward W., Faull, Richard L. M., Curtis, Maurice A., Graham, Scott E., Park, Thomas I-H., Dragunow, Mike
Publicado 2015

Allele-Specific Knockdown of ALS-Associated Mutant TDP-43 in Neural Stem Cells Derived from Induced Pluripotent Stem Cells

por Nishimura, Agnes L., Shum, Carole, Scotter, Emma L., Abdelgany, Amr, Sardone, Valentina, Wright, Jamie, Lee, Youn-Bok, Chen, Han-Jou, Bilican, Bilada, Carrasco, Monica, Maniatis, Tom, Chandran, Siddharthan, Rogelj, Boris, Gallo, Jean-Marc, Shaw, Christopher E.
Publicado 2014

Single-cell image analysis reveals over-expression of organic anion transporting polypeptides (OATPs) in human glioblastoma tissue

por Cooper, Elizabeth, Woolf, Zoe, Swanson, Molly E V, Correia, Jason, Schweder, Patrick, Mee, Edward, Heppner, Peter, Turner, Clinton, Faull, Richard L M, Scotter, Emma L, Denny, William A, Choi, Peter J, Dragunow, Mike, Jose, Jiney, Park, Thomas I-H
Publicado 2022

Single-cell image analysis reveals a protective role for microglia in glioblastoma

por Woolf, Zoe, Swanson, Molly E V, Smyth, Leon C, Mee, Edward W, Schweder, Patrick, Heppner, Peter, Kim, Bernard J H, Turner, Clinton, Oldfield, Robyn L, Curtis, Maurice A, Faull, Richard L M, Scotter, Emma L, Park, Thomas I-H, Dragunow, Michael
Publicado 2021

Novel mutations support a role for Profilin 1 in the pathogenesis of ALS

por Smith, Bradley N., Vance, Caroline, Scotter, Emma L., Troakes, Claire, Wong, Chun Hao, Topp, Simon, Maekawa, Satomi, King, Andrew, Mitchell, Jacqueline C., Lund, Karan, Al-Chalabi, Ammar, Ticozzi, Nicola, Silani, Vincenzo, Sapp, Peter, Brown, Robert H., Landers, John E., Al-Sarraj, Safa, Shaw, Christopher E.
Publicado 2015

PU.1 regulates Alzheimer’s disease-associated genes in primary human microglia

por Rustenhoven, Justin, Smith, Amy M., Smyth, Leon C., Jansson, Deidre, Scotter, Emma L., Swanson, Molly E. V., Aalderink, Miranda, Coppieters, Natacha, Narayan, Pritika, Handley, Renee, Overall, Chris, Park, Thomas I. H., Schweder, Patrick, Heppner, Peter, Curtis, Maurice A., Faull, Richard L. M., Dragunow, Mike
Publicado 2018

Hexanucleotide Repeats in ALS/FTD Form Length-Dependent RNA Foci, Sequester RNA Binding Proteins, and Are Neurotoxic

por Lee, Youn-Bok, Chen, Han-Jou, Peres, João N., Gomez-Deza, Jorge, Attig, Jan, Štalekar, Maja, Troakes, Claire, Nishimura, Agnes L., Scotter, Emma L., Vance, Caroline, Adachi, Yoshitsugu, Sardone, Valentina, Miller, Jack W., Smith, Bradley N., Gallo, Jean-Marc, Ule, Jernej, Hirth, Frank, Rogelj, Boris, Houart, Corinne, Shaw, Christopher E.
Publicado 2013