MEK1/2 inhibition enhances the radiosensitivity of cancer cells by downregulating survival and growth signals mediated by EGFR ligands

por CHUNG, EUN JOO, URICK, MARY ELLEN, KURSHAN, NAAMIT, SHIELD, WILLIAM, ASANO, HIROAKI, SMITH, PAUL D., SCROGGINS, BRADLEY S., BURKEEN, JEFFREY, CITRIN, DEBORAH E.
Publicado 2013

Tonantzitlolone cytotoxicity toward renal cancer cells is PKCθ- and HSF1-dependent

por Sourbier, Carole, Scroggins, Bradley T., Mannes, Philip Z., Liao, Pei-Jyun, Siems, Karsten, Wolf, Dietmar, Beutler, John A., Linehan, W. Marston, Neckers, Leonard
Publicado 2015

Senescence-associated tumor growth is promoted by 12-Lipoxygenase

por Patil, Shilpa, Reedy, Jessica L., Scroggins, Bradley T., White, Ayla O., Kwon, Seokjoo, Shankavaram, Uma, López-Coral, Alfonso, Chung, Eun Joo, Citrin, Deborah E.
Publicado 2022

IL-13 is a therapeutic target in radiation lung injury

por Chung, Su I., Horton, Jason A., Ramalingam, Thirumalai R., White, Ayla O., Chung, Eun Joo, Hudak, Kathryn E., Scroggins, Bradley T., Arron, Joseph R., Wynn, Thomas A., Citrin, Deborah E.
Publicado 2016

Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants

por Prince, Thomas L., Kijima, Toshiki, Tatokoro, Manabu, Lee, Sunmin, Tsutsumi, Shinji, Yim, Kendrick, Rivas, Candy, Alarcon, Sylvia, Schwartz, Harvey, Khamit-Kush, Kofi, Scroggins, Bradley T., Beebe, Kristin, Trepel, Jane B., Neckers, Len
Publicado 2015

Post-translational modification and conformational state of Heat Shock Protein 90 differentially affect binding of chemically diverse small molecule inhibitors

por Beebe, Kristin, Mollapour, Mehdi, Scroggins, Bradley, Prodromou, Chrisostomos, Xu, Wanping, Tokita, Mari, Taldone, Tony, Pullen, Lester, Zierer, Bettina K., Lee, Min-Jung, Trepel, Jane, Buchner, Johannes, Bolon, Daniel, Chiosis, Gabriela, Neckers, Leonard
Publicado 2013

Targeting loss of the Hippo signaling pathway in NF2-deficient papillary kidney cancers

por Sourbier, Carole, Liao, Pei-Jyun, Ricketts, Christopher J., Wei, Darmood, Yang, Youfeng, Baranes, Sarah M., Gibbs, Benjamin K., Ohanjanian, Lernik, Spencer Krane, L., Scroggins, Bradley T., Keith Killian, J., Wei, Ming-Hui, Kijima, Toshiki, Meltzer, Paul S., Citrin, Deborah E., Neckers, Len, Vocke, Cathy D., Marston Linehan, W.
Publicado 2018