The role of short RNA loops in recognition of a single-hairpin exon derived from a mammalian-wide interspersed repeat

por Kralovicova, Jana, Patel, Alpa, Searle, Mark, Vorechovsky, Igor
Publicado 2015

ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling

por Goode, Alice, Rea, Sarah, Sultana, Melanie, Shaw, Barry, Searle, Mark S., Layfield, Robert
Publicado 2016

Structural insights into the targeting of mRNA GU-rich elements by the three RRMs of CELF1

por Edwards, John M., Long, Jed, de Moor, Cornelia H., Emsley, Jonas, Searle, Mark S.
Publicado 2013

Optimal antisense target reducing INS intron 1 retention is adjacent to a parallel G quadruplex

por Kralovicova, Jana, Lages, Ana, Patel, Alpa, Dhir, Ashish, Buratti, Emanuele, Searle, Mark, Vorechovsky, Igor
Publicado 2014

The Highly Repetitive Region of the Helicobacter pylori CagY Protein Comprises Tandem Arrays of an α-Helical Repeat Module

por Delahay, Robin M., Balkwill, Graham D., Bunting, Karen A., Edwards, Wayne, Atherton, John C., Searle, Mark S.
Publicado 2008

Sequence determinants for the tandem recognition of UGU and CUG rich RNA elements by the two N—terminal RRMs of CELF1

por Edwards, John, Malaurie, Emilie, Kondrashov, Alexander, Long, Jed, de Moor, Cornelia H., Searle, Mark S., Emsley, Jonas
Publicado 2011

An ALS-associated variant of the autophagy receptor SQSTM1/p62 reprograms binding selectivity toward the autophagy-related hATG8 proteins

por Brennan, Andrew, Layfield, Robert, Long, Jed, Williams, Huw E.L., Oldham, Neil J., Scott, Daniel, Searle, Mark S.
Publicado 2021

SilE is an intrinsically disordered periplasmic “molecular sponge” involved in bacterial silver resistance

por Asiani, Karishma R., Williams, Huw, Bird, Louise, Jenner, Matthew, Searle, Mark S., Hobman, Jon L., Scott, David J., Soultanas, Panos
Publicado 2016

G-quadruplex ligands mediate downregulation of DUX4 expression

por Ciszewski, Lukasz, Lu-Nguyen, Ngoc, Slater, Alex, Brennan, Andrew, Williams, Huw E L, Dickson, George, Searle, Mark S, Popplewell, Linda
Publicado 2020

DNA replication initiation in Bacillus subtilis: structural and functional characterization of the essential DnaA–DnaD interaction

por Martin, Eleyna, Williams, Huw E L, Pitoulias, Matthaios, Stevens, Daniel, Winterhalter, Charles, Craggs, Timothy D, Murray, Heath, Searle, Mark S, Soultanas, Panos
Publicado 2019

A sequence-based approach for prediction of CsrA/RsmA targets in bacteria with experimental validation in Pseudomonas aeruginosa

por Kulkarni, Prajna R., Jia, Tao, Kuehne, Sarah A., Kerkering, Thomas M., Morris, Elizabeth R., Searle, Mark S., Heeb, Stephan, Rao, Jayasimha, Kulkarni, Rahul V.
Publicado 2014

Defective recognition of LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD

por Goode, Alice, Butler, Kevin, Long, Jed, Cavey, James, Scott, Daniel, Shaw, Barry, Sollenberger, Jill, Gell, Christopher, Johansen, Terje, Oldham, Neil J., Searle, Mark S., Layfield, Robert
Publicado 2016

Structural Rearrangement in an RsmA/CsrA Ortholog of Pseudomonas aeruginosa Creates a Dimeric RNA-Binding Protein, RsmN

por Morris, Elizabeth R., Hall, Gareth, Li, Chan, Heeb, Stephan, Kulkarni, Rahul V., Lovelock, Laura, Silistre, Hazel, Messina, Marco, Cámara, Miguel, Emsley, Jonas, Williams, Paul, Searle, Mark S.
Publicado 2013

A Targeted Oligonucleotide Enhancer of SMN2 Exon 7 Splicing Forms Competing Quadruplex and Protein Complexes in Functional Conditions

por Smith, Lindsay D., Dickinson, Rachel L., Lucas, Christian M., Cousins, Alex, Malygin, Alexey A., Weldon, Carika, Perrett, Andrew J., Bottrill, Andrew R., Searle, Mark S., Burley, Glenn A., Eperon, Ian C.
Publicado 2014

Paget disease of bone-associated UBA domain mutations of SQSTM1 exert distinct effects on protein structure and function

por Goode, Alice, Long, Jed E., Shaw, Barry, Ralston, Stuart H., Visconti, Micaela Rios, Gianfrancesco, Fernando, Esposito, Teresa, Gennari, Luigi, Merlotti, Daniela, Rendina, Domenico, Rea, Sarah L., Sultana, Melanie, Searle, Mark S., Layfield, Robert
Publicado 2014

On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts

por Iachettini, Sara, Stevens, Malcolm FG, Frigerio, Mark, Hummersone, Marc G, Hutchinson, Ian, Garner, Thomas P, Searle, Mark S, Wilson, David W, Munde, Manoj, Nanjunda, Rupesh, D’Angelo, Carmen, Zizza, Pasquale, Rizzo, Angela, Cingolani, Chiara, De Cicco, Federica, Porru, Manuela, D’Incalci, Maurizio, Leonetti, Carlo, Biroccio, Annamaria, Salvati, Erica
Publicado 2013