Unraveling MYC’s Role in Orchestrating Tumor Intrinsic and Tumor Microenvironment Interactions Driving Tumorigenesis and Drug Resistance

por Doha, Zinab O., Sears, Rosalie C.
Publicado 2023

The use of protein phosphatase 2A activators in combination therapies for pancreas cancer

por Allen-Petersen, Brittany L., Sears, Rosalie C.
Publicado 2019

Mission Possible: Advances in MYC Therapeutic Targeting in Cancer

por Allen-Petersen, Brittany L., Sears, Rosalie C.
Publicado 2019

Global rank-invariant set normalization (GRSN) to reduce systematic distortions in microarray data

por Pelz, Carl R, Kulesz-Martin, Molly, Bagby, Grover, Sears, Rosalie C
Publicado 2008

Writing and erasing MYC ubiquitination and SUMOylation

por Chen, Yingxiao, Sun, Xiao-Xin, Sears, Rosalie C., Dai, Mu-Shui
Publicado 2019

Targeting the MYC Ubiquitination-Proteasome Degradation Pathway for Cancer Therapy

por Sun, Xiao-Xin, Li, Yanping, Sears, Rosalie C., Dai, Mu-Shui
Publicado 2021

Diminished WNT → β-catenin → c-MYC signaling is a barrier for malignant progression of BRAF(V600E)-induced lung tumors

por Juan, Joseph, Muraguchi, Teruyuki, Iezza, Gioia, Sears, Rosalie C., McMahon, Martin
Publicado 2014

MYC is not detected in highly proliferating normal spermatogonia but is coupled with CIP2A in testicular cancers

por Ventelä, Sami, Mäkelä, Juho-Antti, Sears, Rosalie C, Toppari, Jorma, Westermarck, Jukka
Publicado 2016

PIN1 Provides Dynamic Control of MYC in Response to Extrinsic Signals

por Cohn, Gabriel M., Liefwalker, Daniel F., Langer, Ellen M., Sears, Rosalie C.
Publicado 2020

Acidic fibroblast growth factor underlies microenvironmental regulation of MYC in pancreatic cancer

por Bhattacharyya, Sohinee, Oon, Chet, Kothari, Aayush, Horton, Wesley, Link, Jason, Sears, Rosalie C., Sherman, Mara H.
Publicado 2020

Modeling differentiation-state transitions linked to therapeutic escape in triple-negative breast cancer

por Chapman, Margaret P., Risom, Tyler, Aswani, Anil J., Langer, Ellen M., Sears, Rosalie C., Tomlin, Claire J.
Publicado 2019

Correction: Modeling differentiation-state transitions linked to therapeutic escape in triple-negative breast cancer

por Chapman, Margaret P., Risom, Tyler, Aswani, Anil J., Langer, Ellen M., Sears, Rosalie C., Tomlin, Claire J.
Publicado 2019

Altering MYC phosphorylation in the epidermis increases the stem cell population and contributes to the development, progression, and metastasis of squamous cell carcinoma

por Wang, Xiaoyan, Langer, Ellen M., Daniel, Colin J., Janghorban, Mahnaz, Wu, Vivian, Wang, Xiao-Jing, Sears, Rosalie C.
Publicado 2020

Identification of a Potent Inhibitor of CREB-Mediated Gene Transcription with Efficacious in Vivo Anticancer Activity

por Xie, Fuchun, Li, Bingbing X., Kassenbrock, Alina, Xue, Changhui, Wang, Xiaoyan, Qian, David Z., Sears, Rosalie C., Xiao, Xiangshu
Publicado 2015

The tumor suppressor phosphatase PP2A-B56α regulates stemness and promotes the initiation of malignancies in a novel murine model

por Janghorban, Mahnaz, Langer, Ellen M., Wang, Xiaoyan, Zachman, Derek, Daniel, Colin J., Hooper, Jody, Fleming, William H., Agarwal, Anupriya, Sears, Rosalie C.
Publicado 2017

HuR Plays a Role in Double-Strand Break Repair in Pancreatic Cancer Cells and Regulates Functional BRCA1-Associated-Ring-Domain-1(BARD1) Isoforms

por Jain, Aditi, McCoy, Matthew, Coats, Carolyn, Brown, Samantha Z., Addya, Sankar, Pelz, Carl, Sears, Rosalie C., Yeo, Charles J., Brody, Jonathan R.
Publicado 2022

Robust biomarker discovery through multiplatform multiplex image analysis of breast cancer clinical cohorts

por Eng, Jennifer, Bucher, Elmar, Hu, Zhi, Sanders, Melinda, Chakravarthy, Bapsi, Gonzalez, Paula, Pietenpol, Jennifer A., Gibbs, Summer L., Sears, Rosalie C., Chin, Koei
Publicado 2023

Development of a blood-based extracellular vesicle classifier for detection of early-stage pancreatic ductal adenocarcinoma

por Hinestrosa, Juan Pablo, Sears, Rosalie C., Dhani, Harmeet, Lewis, Jean M., Schroeder, Gregor, Balcer, Heath I., Keith, Dove, Sheppard, Brett C., Kurzrock, Razelle, Billings, Paul R.
Publicado 2023

Microfluidics Formulated Liposomes of Hypoxia Activated Prodrug for Treatment of Pancreatic Cancer

por Shah, Vidhi M., Dorrell, Craig, Al-Fatease, Adel, Allen-Petersen, Brittany L., Woo, Yeonhee, Bortnyak, Yuliya, Gheewala, Rohi, Sheppard, Brett C., Sears, Rosalie C., Alani, Adam WG.
Publicado 2022

Post-translational modification localizes MYC to the nuclear pore basket to regulate a subset of target genes involved in cellular responses to environmental signals

por Su, Yulong, Pelz, Carl, Huang, Tao, Torkenczy, Kristof, Wang, Xiaoyan, Cherry, Allison, Daniel, Colin J., Liang, Juan, Nan, Xiaolin, Dai, Mu-Shui, Adey, Andrew, Impey, Soren, Sears, Rosalie C.
Publicado 2018