Targeted inhibition of the COP9 signalosome for treatment of cancer

por Schlierf, Anita, Altmann, Eva, Quancard, Jean, Jefferson, Anne B., Assenberg, René, Renatus, Martin, Jones, Matthew, Hassiepen, Ulrich, Schaefer, Michael, Kiffe, Michael, Weiss, Andreas, Wiesmann, Christian, Sedrani, Richard, Eder, Jörg, Martoglio, Bruno
Publicado 2016

Small-molecule factor B inhibitor for the treatment of complement-mediated diseases

por Schubart, Anna, Anderson, Karen, Mainolfi, Nello, Sellner, Holger, Ehara, Takeru, Adams, Christopher M., Mac Sweeney, Aengus, Liao, Sha-Mei, Crowley, Maura, Littlewood-Evans, Amanda, Sarret, Sophie, Wieczorek, Grazyna, Perrot, Ludovic, Dubost, Valérie, Flandre, Thierry, Zhang, Yuzhou, Smith, Richard J. H., Risitano, Antonio M., Karki, Rajeshri G., Zhang, Chun, Valeur, Eric, Sirockin, Finton, Gerhartz, Bernd, Erbel, Paulus, Hughes, Nicola, Smith, Thomas M., Cumin, Frederic, Argikar, Upendra A., Haraldsson, Börje, Mogi, Muneto, Sedrani, Richard, Wiesmann, Christian, Jaffee, Bruce, Maibaum, Jürgen, Flohr, Stefanie, Harrison, Richard, Eder, Jörg
Publicado 2019

Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRAS(G12C)

por Weiss, Andreas, Lorthiois, Edwige, Barys, Louise, Beyer, Kim S., Bomio-Confaglia, Claudio, Burks, Heather, Chen, Xueying, Cui, Xiaoming, de Kanter, Ruben, Dharmarajan, Lekshmi, Fedele, Carmine, Gerspacher, Marc, Guthy, Daniel Alexander, Head, Victoria, Jaeger, Ashley, Núñez, Eloísa Jiménez, Kearns, Jeffrey D., Leblanc, Catherine, Maira, Sauveur-Michel, Murphy, Jason, Oakman, Helen, Ostermann, Nils, Ottl, Johannes, Rigollier, Pascal, Roman, Danielle, Schnell, Christian, Sedrani, Richard, Shimizu, Toshio, Stringer, Rowan, Vaupel, Andrea, Voshol, Hans, Wessels, Peter, Widmer, Toni, Wilcken, Rainer, Xu, Kun, Zecri, Frederic, Farago, Anna F., Cotesta, Simona, Brachmann, Saskia M.
Publicado 2022